4BOO: Acetylcholine receptor subunit alpha

The structure and super-organization of acetylcholine receptor-rapsyn complexes class C. Determined by electron microscopy at 42.0 Å resolution. Released 26 Jun 2013.

Method: Electron microscopy
Resolution: 42.0 Å
Organism: TORPEDO MARMORATA
Chains: 5
Atoms: 14,924
Mol. weight: 279.95 kDa
Released: 26 Jun 2013

Explore 4BOO in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4BOO contains 55 α-helices and 72 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	4-13	10
β-strand	29-44	16	1
β-strand	49-60	12	1
α-helix	72-75	4
β-strand	78-81	4	1
α-helix	82-84	3
β-strand	90-92	3	2
β-strand	100-101	2	1
β-strand	107-110	4	1
β-strand	116-118	3	1
β-strand	121-127	7	1
β-strand	140-148	9	2
β-strand	156-159	4	1
β-strand	177-187	11	2
β-strand	199-208	10	2
α-helix	213-238	26
α-helix	240-242	3
α-helix	243-270	28
α-helix	275-277	3
α-helix	278-300	23
α-helix	375-398	24
α-helix	406-435	30

Chain B: 9 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	4-14	11
β-strand	30-34	5	3
β-strand	37-44	8	4
β-strand	49-55	7	4
β-strand	57-61	5	3
β-strand	77-81	5	3
β-strand	90-92	3	5
β-strand	100-101	2	4
β-strand	107-111	5	3
β-strand	115-118	4	3
β-strand	121-126	6	4
β-strand	143-148	6	5
β-strand	153	1	6
β-strand	157-159	3	3
β-strand	187-188	2	7
β-strand	193-195	3	5
β-strand	204	1	6
β-strand	207-210	4	5
β-strand	213-214	2	7
α-helix	221-226	6
α-helix	227-231	5
α-helix	232-240	9
α-helix	248-274	27
α-helix	282-306	25
α-helix	404-429	26
α-helix	433-461	29
α-helix	463-465	3

Chain C: 10 helices, 13 β-strands

Element	Residues	Length	Sheet
α-helix	4-11	8
β-strand	32-46	15	8
β-strand	51-63	13	8
α-helix	71-75	5
β-strand	80-82	3	8
α-helix	84-86	3
β-strand	92-94	3	9
β-strand	103	1	8
β-strand	110-112	3	8
β-strand	117-120	4	8
β-strand	123-128	6	8
α-helix	133-135	3
β-strand	143-150	8	9
β-strand	159-161	3	8
α-helix	180-182	3
β-strand	190-194	5	9
β-strand	197-201	5	9
β-strand	213-223	11	9
α-helix	228-253	26
α-helix	257-283	27
α-helix	289-314	26
α-helix	422-448	27
α-helix	453-479	27

Chain D: 12 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	4-13	10
β-strand	30-32	3	10
β-strand	37-44	8	11
β-strand	49-55	7	11
β-strand	58-60	3	10
α-helix	63-65	3
α-helix	72-75	4
β-strand	78-81	4	12
α-helix	82-84	3
β-strand	90-92	3	13
β-strand	101	1	11
β-strand	107-110	4	12
β-strand	116-118	3	10
β-strand	121-127	7	11
β-strand	141-148	8	13
β-strand	157-159	3	10
α-helix	167-169	3
β-strand	177-187	11	13
β-strand	199-208	10	13
α-helix	213-239	27
α-helix	240-242	3
α-helix	243-270	28
α-helix	275-277	3
α-helix	278-300	23
α-helix	375-400	26
α-helix	405-435	31

Chain E: 14 helices, 15 β-strands

Element	Residues	Length	Sheet
α-helix	3-13	11
β-strand	30-43	14	14
β-strand	48-60	13	14
α-helix	62-64	3
β-strand	77	1	14
α-helix	81-83	3
β-strand	89-91	3	15
β-strand	100	1	14
β-strand	108-109	2	14
β-strand	114-117	4	14
β-strand	120-125	6	14
α-helix	139	1
β-strand	140	1	16
α-helix	141	1
β-strand	143-147	5	15
β-strand	157-158	2	14
α-helix	173-175	3
β-strand	183-187	5	16
β-strand	192-193	2	15
β-strand	207-210	4	15
β-strand	213-216	4	16
α-helix	222-245	24
α-helix	248-250	3
α-helix	251-278	28
α-helix	284-306	23
α-helix	415-441	27
α-helix	444-461	18
α-helix	462-466	5
α-helix	467-473	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Acetylcholine receptor subunit alpha	A, D	protein	461	TORPEDO MARMORATA	P02711 (AlphaFold model)
Acetylcholine receptor beta subunit	B	protein	493	TORPEDO MARMORATA	Q6S3I0 (AlphaFold model)
Acetylcholine receptor delta subunit	C	protein	522	TORPEDO MARMORATA	Q6S3H8 (AlphaFold model)
Acetylcholine receptor gamma subunit	E	protein	505	TORPEDO MARMORATA	Q6S3H9 (AlphaFold model)

Sequence of entity 1 (A, D), FASTA

>4BOO_1 ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA (chains A, D)
MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQ
LIQLINVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNA
DGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKV
SISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVV
NVIIPCLLFSFLTVLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGK
YMLFTMIFVISSIIVTVVVINTHHRSPSTHTMPQWVRKIFINTIPNVMFFSTMKRASKEK
QENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAA
EEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG

Sequence of entity 2 (B), FASTA

>4BOO_2 ACETYLCHOLINE RECEPTOR BETA SUBUNIT (chains B)
MEDVRRMALGLVVMMALALSGVGASVMEDTLLSVLFENYNPKVRPSQTVGDKVTVRVGLT
LTSLLILNEKNEEMTTSVFLNLAWTDYRLQWDPAAYEGIKDLSIPSDDVWQPDIVLMNNN
DGSFEITLHVNVLVQHTGAVSWHPSAIYRSSCTIKVMYFPFDWQNCTMVFKSYTYDTSEV
ILQHALDAKGEREVKEIMINQDAFTENGQWSIEHKPSRKNWRSDDPSYEDVTFYLIIQRK
PLFYIVYTIVPCILISILAILVFYLPPDAGEKMSLSISALLALTVFLLLLADKVPETSLS
VPIIISYLMFIMILVAFSVILSVVVLNLHHRSPNTHTMPNWIRQIFIETLPPFLWIQRPV
TTPSPDSKPTIISRANDEYFIRKPAGDFVCPVDNARVAVQPERLFSEMKWHLNGLTQPVT
LPQDLKEAVEAIKYIAEQLESASEFDDLKKDWQYVAMVADRLFLYIFITMCSIGTFSIFL
DASHNVPPDNPFA

Sequence of entity 3 (C), FASTA

>4BOO_3 ACETYLCHOLINE RECEPTOR DELTA SUBUNIT (chains C)
MGNIHFVYLLISCLYYSGCSGVNEEERLINDLLIVNKYNKHVRPVKHNNEVVNIALSLTL
SNLISLKETDETLTTNVWMDHAWYDHRLTWNASEYSDISILRLRPELIWIPDIVLQNNND
GQYNVAYFCNVLVRPNGYVTWLPPAIFRSSCPINVLYFPFDWQNCSLKFTALNYNANEIS
MDLMTDTIDGKDYPIEWIIIDPEAFTENGEWEIIHKPAKKNIYGDKFPNGTNYQDVTFYL
IIRRKPLFYVINFITPCVLISFLAALAFYLPAESGEKMSTAICVLLAQAVFLLLTSQRLP
ETALAVPLIGKYLMFIMSLVTGVVVNCGIVLNFHFRTPSTHVLSTRVKQIFLEKLPRILH
MSRVDEIEQPDWQNDLKLRRSSSVGYISKAQEYFNIKSRSELMFEKQSERHGLVPRVTPR
IGFGNNNENIAASDQLHDEIKSGIDSTNYIVKQIKEKNAYDEEVGNWNLVGQTIDRLSMF
IITPVMVLGTIFIFVMGNFNRPPAKPFEGDPFDYSSDHPRCA

Sequence of entity 4 (E), FASTA

>4BOO_4 ACETYLCHOLINE RECEPTOR GAMMA SUBUNIT (chains E)
MVLTLLLIICLALEVRSNEEGRLIEKLLGDYDKRIKPAKTLDHVIDVTLKLTLTNLISLN
EKEEALTTNVWIEIQWNDYRLSWNTSEYEGIDLVRIPSELLWLPDVVLENNVDGQFEVAY
YANVLVYNDGSMYWLPPAIYRSTCPIAVTYFPFDWQNCSLVFRSQTYNAHEVNLQLSAEE
GEVVEWIHIDPEDFTENGEWTIRHRPAKKNYNWQLTKDDIDFQEIIFFLIIQRKPLFYII
NIIAPCVLISSLVVLVYFLPAQAGGQKCTLSISVLLAQTIFLFLIAQKVPETSLNVPLIG
KYLIFVMFVSLVIVTNCVIVLNVSLRTPNTHSLSEKIKHLFLEFLPKYLGMHLEPSEETP
EKPQPRRRSSFGIMIKAEEYILKKPRSELMFEEQKDRHGLKRVNKMTSDIDIGTTVDLYK
DLANFAPEIKSCVEACNFIAKSTKEQNDSGSENENWVLIGKVIDKACFWIALLLFSLGTL
AIFLTGHLNQVPEFPFPGDPRKYVP

Primary citation

Structure and Superorganization of Acetylcholine Receptor-Rapsyn Complexes. Zuber, B., Unwin, N. Proc Natl Acad Sci U S A (2013) 110:10622. DOI 10.1073/PNAS.1301277110 · PubMed

Other PDB entries of the same protein (UniProt P02711 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1OED 4.0 Å, Structure of acetylcholine receptor pore from electron images
2BG9 4.0 Å, Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
4AQ5 6.2 Å, Gating movement in acetylcholine receptor analysed by time-resolved electron…
4AQ9 6.2 Å, Gating movement in acetylcholine receptor analysed by time- resolved electron…
4BON 40.0 Å, The structure and super-organization of acetylcholine receptor-rapsyn complexes class B
4BOI 41.0 Å, The structure and super-organization of acetylcholine receptor-rapsyn complexes class A
4BOR 42.0 Å, The structure and super-organization of acetylcholine receptor-rapsyn complexes class D
4BOT 42.0 Å, The structure and super-organization of acetylcholine receptor- rapsyn complexes class E
4BOG 50.0 Å, The structure and super-organization of acetylcholine receptor-rapsyn complexes
1L4W NMR structure of an AChR-peptide (Torpedo Californica, alpha-subunit residues 182-202)…
1LJZ NMR structure of an AChR-peptide (Torpedo Californica, alpha-subunit residues 182-202)…

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