4C0O: Transportin 3

Transportin 3 in complex with phosphorylated ASF/SF2. Determined by X-ray diffraction at 2.56 Å resolution. Released 22 Jan 2014.

Method
X-ray diffraction
Resolution
2.56 Å
Organism
HOMO SAPIENS
Chains
4
Atoms
15,858
Mol. weight
237.78 kDa
Released
22 Jan 2014

Explore 4C0O in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4C0O contains 130 α-helices and 12 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 61 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix4-74
α-helix8-2013
α-helix24-3916
α-helix43-5311
α-helix57-7317
α-helix75-773
α-helix82-9615
α-helix102-11716
α-helix125-1339
α-helix140-15213
α-helix153-1553
α-helix163-18826
α-helix195-21117
α-helix216-2205
α-helix223-23311
α-helix239-25416
α-helix263-27412
α-helix277-2859
α-helix289-30517
α-helix307-3126
α-helix317-3193
α-helix322-33110
α-helix336-3394
α-helix340-3423
α-helix343-35513
α-helix362-3643
α-helix366-37914
α-helix381-3833
α-helix395-41016
α-helix411-4133
α-helix416-42510
α-helix434-44714
α-helix456-46712
α-helix475-48713
α-helix490-4945
α-helix496-4983
α-helix499-51012
α-helix513-5153
α-helix516-52914
α-helix538-5469
α-helix548-5503
α-helix555-56915
α-helix574-59522
α-helix609-62113
α-helix635-65117
α-helix656-67318
α-helix681-69414
α-helix698-71114
α-helix718-73720
α-helix741-7444
α-helix746-76217
α-helix764-7685
α-helix773-78311
α-helix789-80315
α-helix804-8063
α-helix815-83925
α-helix840-8445
α-helix847-8493
α-helix850-87728
α-helix892-90312
α-helix908-91912
Chain B: 61 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix4-74
α-helix8-2013
α-helix24-3916
α-helix43-5311
α-helix57-7317
α-helix75-773
α-helix80-9617
α-helix102-11716
α-helix125-1339
α-helix140-15213
α-helix153-1553
α-helix163-17513
α-helix177-18812
α-helix195-21117
α-helix216-2205
α-helix223-2319
α-helix239-25517
α-helix263-27412
α-helix277-2859
α-helix289-30517
α-helix307-3126
α-helix317-3193
α-helix322-33110
α-helix336-3394
α-helix340-3423
α-helix343-35513
α-helix362-37918
α-helix381-3833
α-helix395-41016
α-helix411-4133
α-helix416-42510
α-helix434-44714
α-helix456-46712
α-helix475-48713
α-helix489-4946
α-helix496-4983
α-helix499-51012
α-helix513-5153
α-helix516-52914
α-helix538-5469
α-helix548-5503
α-helix555-56915
α-helix574-59522
α-helix609-62113
α-helix635-65117
α-helix656-67318
α-helix681-69414
α-helix698-71114
α-helix718-73720
α-helix741-7444
α-helix746-76217
α-helix764-7685
α-helix773-78311
α-helix789-80315
α-helix804-8063
α-helix815-83925
α-helix840-8445
α-helix847-8493
α-helix850-87728
α-helix892-90312
α-helix908-92013
Chains C and D: 4 helices, 6 β-strands
ElementResiduesLengthSheet
β-strand122-12651
α-helix134-1418
β-strand147-15261
β-strand158-16251
α-helix165-1706
α-helix171-1755
β-strand179-18132
β-strand187-18932
β-strand191-19441
α-helix198-2003

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transportin-3A, Bprotein923HOMO SAPIENSQ9Y5L0 (AlphaFold model)
Serine/arginine-rich splicing factor 1C, Dprotein125HOMO SAPIENSQ07955 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4C0O_1 TRANSPORTIN-3 (chains A, B)
MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESC
YFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMP
SWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTV
VSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSN
LHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFT
ELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEV
IHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECF
AQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYT
SIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNG
LLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEP
SNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVE
RCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQG
LLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWA
IASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHT
CCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHK
QVTSAEECKQVCWALRDFTRLFR
Sequence of entity 2 (C, D), FASTA
>4C0O_2 SERINE/ARGININE-RICH SPLICING FACTOR 1 (chains C, D)
GAPRGRYGPPSRRSENRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRK
EDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRSRSNSRSRS
YSPRR

Primary citation

Structural Basis for Nuclear Import of Splicing Factors by Human Transportin 3. Maertens, G.N., Cook, N.J., Wang, W. et al. Proc Natl Acad Sci U S A (2014) 111:2728. DOI 10.1073/PNAS.1320755111 · PubMed

Other PDB entries of the same protein (UniProt Q9Y5L0 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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