4C0P: Unliganded Transportin 3

Unliganded Transportin 3. Determined by X-ray diffraction at 2.95 Å resolution. Released 22 Jan 2014.

Method

X-ray diffraction

Resolution

2.95 Å

Organism

HOMO SAPIENS

Chains

4

Atoms

28,293

Mol. weight

417.74 kDa

Ligands

DTT

Released

22 Jan 2014

Explore 4C0P in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4C0P contains 250 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 63 helices, 0 β-strands

Molecules and chains

>4C0P_1 TRANSPORTIN-3 (chains A, B, C, D)
MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESC
YFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMP
SWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTV
VSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSN
LHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFT
ELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEV
IHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECF
AQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYT
SIELVGEMSEVVDRNPQFLDPVLGYLMKGLAEKPLASAAAKAIHNICSVCRDHMAQHFNG
LLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEP
SNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVE
RCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQG
LLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWA
IASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHT
CCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHK
QVTSAEECKQVCWALRDFTRLFR

Ligands and cofactors

Primary citation

Structural Basis for Nuclear Import of Splicing Factors by Human Transportin 3. Maertens, G.N., Cook, N.J., Wang, W. et al. Proc Natl Acad Sci U S A (2014) 111:2728. DOI 10.1073/PNAS.1320755111 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q9Y5L0 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 4C0O 2.56 Å, Transportin 3 in complex with phosphorylated ASF/SF2
• 6GX9 2.7 Å, Crystal structure of the TNPO3 - CPSF6 RSLD complex
• 4OL0 2.9 Å, Crystal structure of transportin-SR2, a karyopherin involved in human disease, in…
• 8CMK 2.94 Å, Transportin-3 TNPO3 in complex with RSY region of CIRBP
• 4C0Q 3.42 Å, Transportin 3 in complex with Ran(Q69L)GTP

Browse structure collections

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