4C0Q: Transportin 3

Transportin 3 in complex with Ran(Q69L)GTP. Determined by X-ray diffraction at 3.42 Å resolution. Released 22 Jan 2014.

Method
X-ray diffraction
Resolution
3.42 Å
Organism
HOMO SAPIENS
Chains
4
Atoms
15,766
Mol. weight
260.5 kDa
Ligands
MG, GTP
Released
22 Jan 2014

Explore 4C0Q in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4C0Q contains 129 α-helices and 14 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 59 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix8-2013
α-helix24-3916
α-helix43-5311
α-helix57-7317
α-helix75-773
α-helix82-9615
α-helix102-11716
α-helix125-1339
α-helix140-15213
α-helix153-1553
α-helix163-18826
α-helix196-21116
α-helix216-2205
α-helix223-23311
α-helix239-25517
α-helix263-27412
α-helix277-2859
α-helix289-30517
α-helix307-3126
α-helix317-3193
α-helix322-33110
α-helix336-3394
α-helix340-3423
α-helix343-35210
α-helix366-37914
α-helix381-3833
α-helix395-41016
α-helix411-4133
α-helix416-42510
α-helix434-44714
α-helix456-46712
α-helix475-48713
α-helix490-4945
α-helix496-4983
α-helix499-51012
α-helix513-5153
α-helix516-52914
α-helix538-5469
α-helix548-5503
α-helix555-56915
α-helix574-59421
α-helix609-62113
α-helix635-65117
α-helix656-67015
α-helix681-69414
α-helix699-71113
α-helix718-73720
α-helix741-7444
α-helix746-76217
α-helix764-7685
α-helix773-78311
α-helix789-80315
α-helix804-8063
α-helix815-83925
α-helix840-8445
α-helix847-8493
α-helix850-87728
α-helix892-90312
α-helix908-92013
Chain B: 54 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix8-2013
α-helix24-3916
α-helix43-5311
α-helix58-7316
α-helix75-773
α-helix80-9617
α-helix102-11817
α-helix125-1339
α-helix140-15314
α-helix167-18620
α-helix198-21114
α-helix216-2205
α-helix223-23311
α-helix239-25517
α-helix263-27412
α-helix277-2859
α-helix289-30517
α-helix307-3126
α-helix317-3193
α-helix322-33110
α-helix336-3394
α-helix340-3423
α-helix343-35412
α-helix363-37917
α-helix381-3833
α-helix395-41016
α-helix411-4133
α-helix416-42510
α-helix434-44613
α-helix459-4679
α-helix475-48612
α-helix496-4983
α-helix499-51012
α-helix513-5153
α-helix516-52510
α-helix555-5595
α-helix582-59312
α-helix609-62012
α-helix643-6519
α-helix656-67015
α-helix684-69411
α-helix699-7046
α-helix723-73715
α-helix741-7444
α-helix746-76217
α-helix773-78311
α-helix789-80315
α-helix804-8063
α-helix820-83920
α-helix840-8445
α-helix847-8493
α-helix850-87627
α-helix894-90310
α-helix908-92013
Chains C and D: 8 helices, 7 β-strands
ElementResiduesLengthSheet
β-strand10-1781
α-helix23-319
β-strand45-55111
β-strand57-66101
α-helix70-723
α-helix76-805
β-strand85-9171
α-helix95-995
α-helix101-1099
β-strand117-12261
α-helix133-1353
α-helix138-1403
β-strand144-14851
α-helix159-16911
β-strand17611

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transportin-3A, Bprotein923HOMO SAPIENSQ9Y5L0 (AlphaFold model)
GTP-binding nuclear protein ranC, Dprotein215HOMO SAPIENSP62826 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4C0Q_1 TRANSPORTIN-3 (chains A, B)
MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESC
YFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMP
SWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTV
VSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSN
LHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFT
ELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEV
IHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECF
AQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYT
SIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEKPLASAAAKAIHNICSVCRDHMAQHFNG
LLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEP
SNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVE
RCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQG
LLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWA
IASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHT
CCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHK
QVTSAEECKQVCWALRDFTRLFR
Sequence of entity 2 (C, D), FASTA
>4C0Q_2 GTP-BINDING NUCLEAR PROTEIN RAN (chains C, D)
AAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKF
NVWDTAGLEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCG
NKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPA
LAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL

Ligands and cofactors

IDNameFormulaCopies
MGMagnesium ionMg2
GTPGuanosine-5'-triphosphateC10 H16 N5 O14 P32

Primary citation

Structural Basis for Nuclear Import of Splicing Factors by Human Transportin 3. Maertens, G.N., Cook, N.J., Wang, W. et al. Proc Natl Acad Sci U S A (2014) 111:2728. DOI 10.1073/PNAS.1320755111 · PubMed

Other PDB entries of the same protein (UniProt Q9Y5L0 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 4C0Q directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.