4D0M: Phosphatidylinositol 4-kinase beta

Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding domain of FIP3. Determined by X-ray diffraction at 6.0 Å resolution. Released 28 May 2014.

Method

X-ray diffraction

Resolution

6.0 Å

Organism

HOMO SAPIENS

Chains

36

Atoms

65,970

Mol. weight

1149.87 kDa

Ligands

MG, GSP, 093

Released

28 May 2014

Explore 4D0M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4D0M contains 459 α-helices and 184 β-strands across 36 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains a, E, i and K: 2 helices, 1 β-strand

Molecules and chains

>4D0M_1 PHOSPHATIDYLINOSITOL 4-KINASE BETA (chains A, C, G, I, M, O, Q, S, W, Y, c, g)
GSQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQ
LLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRK
LILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTAANPKV
ENEDEPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAG
FDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRRDPEDPSAVAL
KEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPL
WIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNF
VQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTE
FVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLK
ERFHMSMTEEQLQLLVEQMVDGSMRS

>4D0M_2 RAS-RELATED PROTEIN RAB-11A (chains B, D, H, J, N, P, R, T, X, Z, d, h)
GSHMGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDG
KTIKAQIWDTAGLERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNI
VIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVS
QKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI

>4D0M_3 RAB11 FAMILY-INTERACTING PROTEIN 3 (chains E, F, K, L, U, V, a, b, e, f, i, j)
GSHMSSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK

Ligands and cofactors

Primary citation

Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors. Burke, J.E., Inglis, A.J., Perisic, O. et al. Science (2014) 344:1035. DOI 10.1126/SCIENCE.1253397 · PubMed

Related structures

Other PDB entries of the same protein (UniProt Q9UBF8 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 8Q6F 1.51 Å, Human PI4KIIIB in complex with covalently bound inhibitor (compound 4)
• 8Q6G 1.54 Å, Human PI4KIIIB in complex with covalently bound inhibitor (compound 8)
• 8Q6H 1.94 Å, Human PI4KIIIB in complex with covalently bound inhibitor (compound 11)
• 5NAS 2.08 Å, Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide
• 5LX2 2.58 Å, Lt 14-3-3 in complex with PI4KIIIB peptide
• 5C46 2.65 Å, Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta…
• 6GL3 2.77 Å, Crystal structure of human Phosphatidylinositol 4-kinase III beta (PI4KIIIbeta) in…
• 4D0L 2.94 Å, Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS
• 8VOF 3.0 Å, GI targeted CpPI4K inhibitor
• 5C4G 3.2 Å, Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta…
• 5EUQ 3.2 Å, Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta…
• 5FBR 3.28 Å, PI4KB in complex with Rab11 and the MI359 Inhibitor

Browse structure collections

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