4D2H: Tetramerisation domain of human CtIP

Crystal structure of the tetramerisation domain of human CtIP. Determined by X-ray diffraction at 1.9 Å resolution. Released 14 Jan 2015.

Method: X-ray diffraction
Resolution: 1.9 Å
Organism: HOMO SAPIENS
Chains: 8
Atoms: 2,474
Mol. weight: 37.44 kDa
Released: 14 Jan 2015

Explore 4D2H in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4D2H contains 9 α-helices and 0 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	17-50	34

Chains B and G: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	19-46	28

Chains C and F: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	20-51	32

Chains D and E: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	20-47	28

Chain H: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	20-45	26
α-helix	46-50	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
RBBP8	A, B, C, D, E, F, G, H	protein	38	HOMO SAPIENS	Q99708 (AlphaFold model)

Sequence of entity 1 (A, B, C, D, E, F, G, H), FASTA

>4D2H_1 RBBP8 (chains A, B, C, D, E, F, G, H)
GSMSDFKDLWTKLKECHDREVQGLQVKVTKLKQERILD

Primary citation

Ctip Tetramer Assembly is Required for DNA-End Resection and Repair. Davies, O.R., Forment, J.V., Sun, M. et al. Nat Struct Mol Biol (2015) 22:150. DOI 10.1038/NSMB.2937 · PubMed

Other PDB entries of the same protein (UniProt Q99708 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1Y98 2.5 Å, Structure of the BRCT repeats of BRCA1 bound to a CtIP phosphopeptide.
7BGF 2.8 Å, Crystal structure of the N-terminal dimeric coiled coil of the human ctip protein

Browse structure collections

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