Crystal Structure of the amyloid-fibril forming peptide KDWSFY derived from human Beta 2 Microglobulin (58-63). Determined by X-ray diffraction at 0.97 Å resolution. Released 19 Dec 2012.
Explore 4E0K in 3D Show helices and sheets RCSB PDB PDBe
4E0K contains 0 α-helices and 4 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3-5 | 3 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Amyloidogenic peptide segment KDWSFY | A, B, C, D | protein | 6 | P61769 (AlphaFold model) |
>4E0K_1 Amyloidogenic peptide segment KDWSFY (chains A, B, C, D) KDWSFY
| ID | Name | Formula | Copies |
|---|---|---|---|
| PE4 | 2-{2-[2-(2-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-etha… | C16 H34 O8 | 2 |
Water and common crystallization additives (NA) are not listed.
Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates. Liu, C., Zhao, M., Jiang, L. et al. Proc Natl Acad Sci U S A (2012) 109:20913-20918. DOI 10.1073/pnas.1218792109 · PubMed
Other PDB entries of the same protein (UniProt P61769 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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