Crystal structure of the cdk2 in complex with aminopyrazole inhibitor. Determined by X-ray diffraction at 1.26 Å resolution. Released 1 May 2013.
Explore 4EK4 in 3D Show helices and sheets RCSB PDB PDBe
4EK4 contains 19 α-helices and 11 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-12 | 9 | 1 |
| β-strand | 17-23 | 7 | 1 |
| β-strand | 29-34 | 6 | 1 |
| α-helix | 46-54 | 9 | |
| α-helix | 55-57 | 3 | |
| β-strand | 63 | 1 | 2 |
| β-strand | 66-72 | 7 | 1 |
| β-strand | 75-81 | 7 | 1 |
| β-strand | 85-86 | 2 | 2 |
| α-helix | 87-93 | 7 | |
| α-helix | 101-120 | 20 | |
| α-helix | 130-132 | 3 | |
| β-strand | 133-135 | 3 | 2 |
| β-strand | 141-143 | 3 | 2 |
| α-helix | 148-152 | 5 | |
| β-strand | 157 | 1 | 3 |
| α-helix | 162 | 1 | |
| β-strand | 163 | 1 | 3 |
| α-helix | 164-165 | 2 | |
| α-helix | 171-174 | 4 | |
| α-helix | 183-198 | 16 | |
| α-helix | 208-219 | 12 | |
| α-helix | 230-232 | 3 | |
| α-helix | 243-247 | 5 | |
| α-helix | 248-251 | 4 | |
| α-helix | 257-266 | 10 | |
| α-helix | 275-276 | 2 | |
| α-helix | 277-281 | 5 | |
| α-helix | 284-286 | 3 | |
| α-helix | 292-294 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 2 | A | protein | 299 | Homo sapiens | P24941 (AlphaFold model) |
>4EK4_1 Cyclin-dependent kinase 2 (chains A) XMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
| ID | Name | Formula | Copies |
|---|---|---|---|
| 1CK | 4-bromo-N-(5-methyl-1H-pyrazol-3-yl)benzamide | C11 H10 Br N3 O | 1 |
Water and common crystallization additives (NA) are not listed.
Crystal structure of the cdk2 in complex with aminopyrazole inhibitor. Kang, Y.N., Stuckey, J.A. To be published.
Other PDB entries of the same protein (UniProt P24941 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 4EK4 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.