4EQ6: Psy3-Csm2 complex from budding yeast

The crystal structure of Psy3-Csm2 complex from budding yeast. Determined by X-ray diffraction at 1.8 Å resolution. Released 1 Aug 2012.

Method: X-ray diffraction
Resolution: 1.8 Å
Organism: Saccharomyces cerevisiae
Chains: 2
Atoms: 3,337
Mol. weight: 54.96 kDa
Released: 1 Aug 2012

Explore 4EQ6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4EQ6 contains 24 α-helices and 13 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	3-5	3
β-strand	9-13	5	1
α-helix	17-28	12
β-strand	34-41	8	1
α-helix	48-54	7
α-helix	60-62	3
α-helix	63-67	5
β-strand	69-73	5	1
α-helix	77-98	22
β-strand	110-117	8	1
α-helix	119-129	11
α-helix	132-151	20
β-strand	157-165	9	1
α-helix	167-170	4
α-helix	171-175	5
α-helix	199-206	8
β-strand	210-211	2	1

Chain B: 13 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	2-6	5
α-helix	12-15	4
α-helix	27-29	3
α-helix	35-39	5
β-strand	43-48	6	2
α-helix	53-54	2
α-helix	55-61	7
β-strand	69-74	6	2
β-strand	89-92	4	2
α-helix	100-112	13
α-helix	114-119	6
β-strand	130-136	7	2
α-helix	138-140	3
α-helix	154-171	18
β-strand	174-179	6	2
α-helix	182-186	5
α-helix	188-190	3
α-helix	213-218	6
β-strand	221-226	6	2
β-strand	233-236	4	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Chromosome segregation in meiosis protein 2	A	protein	214	Saccharomyces cerevisiae	P40465 (AlphaFold model)
Platinum sensitivity protein 3	B	protein	256	Saccharomyces cerevisiae	Q12318 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4EQ6_1 Chromosome segregation in meiosis protein 2 (chains A)
MMEYEDLELITIWPSPTKNKLCQFIKQNLSKEHVVTQLFFIDATSSFPLSQFQKLVPPTL
PENVRIYENIRINTCLDLEELSAITVKLLQILSMNKINAQRGTEDAVTEPLKIILYINGL
EVMFRNSQFKSSPQRSHELLRDTLLKLRVMGNDENENASIRTLLEFPKEQLLDYYLKKNN
NTRTSSVRSKRRRIKNGDSLAEYIWKYYADSLFE

Sequence of entity 2 (B), FASTA

>4EQ6_2 Platinum sensitivity protein 3 (chains B)
MGSSHHHHHHSHGSMEVLKNIRIYPLSNFITSTKNYINLPNELRNLISEEQESKLGFLHI
IESDFKPSVALQKLVNCTTGDEKILIIDIVSIWSQQKQRQHGAIYMNSLSCINITGLIVF
LELLYDSPMDALRRCQVDNFNFQLRGIVIDNLSFLNFESDKNYDVINLSKFEKLFKILRK
LREFLGCWIITKSFPTDFYNGIENTLVDKWSIKRKSGVTLYPTKLPDSYMKGMDLIIYRE
VVDGRPQYRRIAALEE

Primary citation

Structural and SAXS analysis of the budding yeast SHU-complex proteins. She, Z., Gao, Z.Q., Liu, Y. et al. FEBS Lett (2012) 586:2306-2312. DOI 10.1016/j.febslet.2012.06.024 · PubMed

Other PDB entries of the same protein (UniProt P40465 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3VU9 1.75 Å, Crystal Structure of Psy3-Csm2 complex
4DT1 1.9 Å, Crystal structure of the Psy3-Csm2 complex
9Q2H 2.74 Å, Rad55-Rad57-SHU homologous recombination complex
9Q2I 3.0 Å, Rad55-Rad57-SHU homologous recombination complex
9Q2C 3.06 Å, Rad55-Rad57-SHU-Rad51 bound to ssDNA with AMP-PNP
9Q2F 3.06 Å, Rad55-Rad57-SHU-Rad51-Rad51 bound to ssDNA with AMP-PNP
5XYN 3.3 Å, The crystal structure of Csm2-Psy3-Shu1-Shu2 complex from budding yeast
9Q2E 3.44 Å, Rad55-Rad57-SHU bound to ssDNA
9Q2L 3.7 Å, Rad55-Rad57(E161Q)-SHU-3xRad51 bound to ssDNA with ATP

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