Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor. Determined by X-ray diffraction at 1.26 Å resolution. Released 8 May 2013.
Explore 4FKL in 3D Show helices and sheets RCSB PDB PDBe
4FKL contains 18 α-helices and 11 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-12 | 9 | 1 |
| β-strand | 17-23 | 7 | 1 |
| β-strand | 29-34 | 6 | 1 |
| α-helix | 46-55 | 10 | |
| β-strand | 63 | 1 | 2 |
| β-strand | 66-71 | 6 | 1 |
| β-strand | 76-81 | 6 | 1 |
| β-strand | 85-86 | 2 | 2 |
| α-helix | 87-93 | 7 | |
| α-helix | 101-120 | 20 | |
| α-helix | 130-132 | 3 | |
| β-strand | 133-135 | 3 | 2 |
| β-strand | 141-143 | 3 | 2 |
| α-helix | 148-152 | 5 | |
| β-strand | 157 | 1 | 3 |
| α-helix | 162 | 1 | |
| β-strand | 163 | 1 | 3 |
| α-helix | 164-165 | 2 | |
| α-helix | 171-174 | 4 | |
| α-helix | 183-198 | 16 | |
| α-helix | 208-219 | 12 | |
| α-helix | 230-232 | 3 | |
| α-helix | 243-247 | 5 | |
| α-helix | 248-251 | 4 | |
| α-helix | 257-266 | 10 | |
| α-helix | 275-276 | 2 | |
| α-helix | 277-281 | 5 | |
| α-helix | 284-286 | 3 | |
| α-helix | 292-294 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 2 | A | protein | 299 | Homo sapiens | P24941 (AlphaFold model) |
>4FKL_1 Cyclin-dependent kinase 2 (chains A) XMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
| ID | Name | Formula | Copies |
|---|---|---|---|
| CK2 | 4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine | C9 H10 N4 S | 1 |
Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor. Kang, Y.N., Stuckey, J.A. To be published.
Other PDB entries of the same protein (UniProt P24941 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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