Crystal structure of the N-terminal domain of Helicobacter pylori CagA protein. Determined by X-ray diffraction at 3.6 Å resolution. Released 22 Aug 2012.
Explore 4G0H in 3D Show helices and sheets RCSB PDB PDBe
4G0H contains 16 α-helices and 15 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 310-311 | 2 | 1 |
| β-strand | 314 | 1 | 1 |
| β-strand | 320 | 1 | 1 |
| β-strand | 323-324 | 2 | 1 |
| β-strand | 336-342 | 7 | 1 |
| β-strand | 351-358 | 8 | 1 |
| β-strand | 363-367 | 5 | 1 |
| α-helix | 377-380 | 4 | |
| β-strand | 381-383 | 3 | 2 |
| β-strand | 390-392 | 3 | 2 |
| α-helix | 393-394 | 2 | |
| α-helix | 395-411 | 17 | |
| α-helix | 415-417 | 3 | |
| α-helix | 420-425 | 6 | |
| α-helix | 427-435 | 9 | |
| α-helix | 438-445 | 8 | |
| β-strand | 448-452 | 5 | 1 |
| β-strand | 460-467 | 8 | 1 |
| β-strand | 470-477 | 8 | 1 |
| β-strand | 491-495 | 5 | 1 |
| β-strand | 503-509 | 7 | 1 |
| β-strand | 537-543 | 7 | 1 |
| α-helix | 556-568 | 13 | |
| α-helix | 572-606 | 35 | |
| α-helix | 610-640 | 31 | |
| α-helix | 647-702 | 56 | |
| α-helix | 703-705 | 3 | |
| α-helix | 721-734 | 14 | |
| α-helix | 740-755 | 16 | |
| α-helix | 766-802 | 37 | |
| α-helix | 806-821 | 16 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Cytotoxicity-associated immunodominant antigen | A | protein | 916 | Helicobacter pylori | P55980 (AlphaFold model) |
>4G0H_1 Cytotoxicity-associated immunodominant antigen (chains A) MTNETIDQTRTPDQTQSQTAFDPQQFINNLQVAFIKVDNVVASFDPDQKPIVDKNDRDNR QAFDGISQLREEYSNKAIKNPTKKNQYFSDFIDKSNDLINKDNLIDVESSTKSFQKFGDQ RYQIFTSWVSHQKDPSKINTRSIRNFMENIIQPPIPDDKEKAEFLKSAKQSFAGIIIGNQ IRTDQKFMGVFDESLKERQEAEKNGGPTGGDWLDIFLSFIFNKKQSSDVKEAINQEPVPH VQPDIATTTTDIQGLPPEARDLLDERGNFSKFTLGDMEMLDVEGVADIDPNYKFNQLLIH NNALSSVLMGSHNGIEPEKVSLLYAGNGGFGDKHDWNATVGYKDQQGNNVATLINVHMKN GSGLVIAGGEKGINNPSFYLYKEDQLTGSQRALSQEEIRNKVDFMEFLAQNNTKLDNLSE KEKEKFQNEIEDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFNNGDLSYTLKDYGK KADKALDREKNVTLQGSLKHDGVMFVDYSNFKYTNASKNPNKGVGATNGVSHLEAGFNKV AVFNLPDLNNLAITSFVRRNLENKLTAKGLSLQEANKLIKDFLSSNKELAGKALNFNKAV AEAKSTGNYDEVKKAQKDLEKSLRKREHLEKEVEKKLESKSGNKNKMEAKAQANSQKDEI FALINKEANRDARAIAYTQNLKGIKRELSDKLEKISKDLKDFSKSFDEFKNGKNKDFSKA EETLKALKGSVKDLGINPEWISKVENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDVI INQKVTDKVDNLNQAVSVAKAMGDFSRVEQVLADLKNFSKEQLAQQAQKNEDFNTGKNSE LYQSVKNSVNKTLVGNGLSGIEATALAKNFSDIKKELNEKFKNFKGELNSKLEGKPIPNP LLGLDSTRTGHHHHHH
Structural insights into Helicobacter pylori oncoprotein CagA interaction with beta 1 integrin. Kaplan-Turkoz, B., Jimenez-Soto, L.F., Dian, C. et al. Proc Natl Acad Sci U S A (2012) 109:14640-14645. DOI 10.1073/pnas.1206098109 · PubMed
Other PDB entries of the same protein (UniProt P55980 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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