Crystal structure of KLHL3/Cul3 complex. Determined by X-ray diffraction at 3.51 Å resolution. Released 13 Mar 2013.
Explore 4HXI in 3D Show helices and sheets RCSB PDB PDBe
4HXI contains 39 α-helices and 5 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 33-45 | 13 | |
| β-strand | 52-55 | 4 | 1 |
| β-strand | 60-63 | 4 | 1 |
| α-helix | 65-71 | 7 | |
| α-helix | 73-79 | 7 | |
| α-helix | 84-87 | 4 | |
| β-strand | 90-92 | 3 | 1 |
| α-helix | 98-110 | 13 | |
| α-helix | 120-129 | 10 | |
| α-helix | 133-145 | 13 | |
| α-helix | 153-162 | 10 | |
| α-helix | 165-172 | 8 | |
| α-helix | 183-189 | 7 | |
| α-helix | 194-201 | 8 | |
| α-helix | 210-213 | 4 | |
| α-helix | 214-222 | 9 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 27-45 | 19 | |
| β-strand | 50 | 1 | 2 |
| β-strand | 52 | 1 | 2 |
| α-helix | 54-66 | 13 | |
| α-helix | 70-84 | 15 | |
| α-helix | 85-89 | 5 | |
| α-helix | 90-94 | 5 | |
| α-helix | 101-122 | 22 | |
| α-helix | 124-128 | 5 | |
| α-helix | 130-133 | 4 | |
| α-helix | 139-147 | 9 | |
| α-helix | 148-152 | 5 | |
| α-helix | 156-173 | 18 | |
| α-helix | 180-193 | 14 | |
| α-helix | 199-201 | 3 | |
| α-helix | 202-206 | 5 | |
| α-helix | 207-227 | 21 | |
| α-helix | 230-250 | 21 | |
| α-helix | 254-256 | 3 | |
| α-helix | 257-264 | 8 | |
| α-helix | 265-270 | 6 | |
| α-helix | 273-277 | 5 | |
| α-helix | 284-289 | 6 | |
| α-helix | 293-303 | 11 | |
| α-helix | 309-329 | 21 | |
| α-helix | 341-354 | 14 | |
| α-helix | 355-359 | 5 | |
| α-helix | 364-377 | 14 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Kelch-like protein 3 | A | protein | 277 | Homo sapiens | Q9UH77 (AlphaFold model) |
| Cullin-3 | B | protein | 386 | Homo sapiens | Q13618 (AlphaFold model) |
>4HXI_1 Kelch-like protein 3 (chains A) MHHHHHHSSGVDLGTENLYFQSNARTITVNPAHMGKAFKVMNELRSKQLLCDVMIVAEDV EIEAHRVVLAACSPYFCAMFTGDMSESAAAAIEIKDVDGQTLSKLIDYIYTAEIEVTEEN VQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHF PEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHV RLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH
>4HXI_2 Cullin-3 (chains B) GLNDIFEAQKIEWHEAMELVPRGSAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFE ELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTA MVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKG EVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIK KVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMRTIVEMENSGLVHMLKNGKTED LGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYRQGLDDLKSRFDRF LLESFNNDRLFKQTIAGDFEYFLNLN
Crystal structure of KLHL3 in complex with Cullin3. Ji, A.X., Prive, G.G. PLoS One (2013) 8:e60445-e60445. DOI 10.1371/journal.pone.0060445 · PubMed
Other PDB entries of the same protein (UniProt Q9UH77 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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