4I1M: Legionella pneumophila GAP domain of LepB

Crystal structure of the Legionella pneumophila GAP domain of LepB. Determined by X-ray diffraction at 2.8 Å resolution. Released 16 Jan 2013.

Method
X-ray diffraction
Resolution
2.8 Å
Organism
Legionella pneumophila subsp. pneumophila
Chains
3
Atoms
6,524
Mol. weight
102.5 kDa
Released
16 Jan 2013

Explore 4I1M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4I1M contains 48 α-helices and 22 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 14 helices, 8 β-strands

ElementResiduesLengthSheet
α-helix326-3283
β-strand32911
α-helix339-35113
β-strand36011
α-helix367-38721
α-helix404-4063
β-strand413-41422
β-strand417-41822
β-strand42313
α-helix425-4339
β-strand43614
β-strand44214
α-helix446-45813
α-helix463-48927
α-helix494-52128
β-strand53813
α-helix543-5486
α-helix551-56111
α-helix569-5768
α-helix578-5803
α-helix581-5899
α-helix600-61415
Chain B: 16 helices, 8 β-strands
ElementResiduesLengthSheet
β-strand328-32925
α-helix339-35113
α-helix355-3573
β-strand359-36025
α-helix367-38721
α-helix404-4063
β-strand413-41426
β-strand417-41826
β-strand42317
α-helix425-4339
β-strand43518
α-helix4411
β-strand44218
α-helix4431
α-helix446-45813
α-helix463-48927
α-helix493-51927
β-strand53817
α-helix543-5486
α-helix551-56111
α-helix567-5682
α-helix569-5768
α-helix581-5888
α-helix600-61415
Chain C: 18 helices, 6 β-strands
ElementResiduesLengthSheet
α-helix318-3258
β-strand327-32939
α-helix339-35214
α-helix355-3573
β-strand358-36039
α-helix367-38721
α-helix404-4063
β-strand414110
β-strand417110
β-strand423111
α-helix425-4328
α-helix446-45813
α-helix463-48927
α-helix493-51725
α-helix518-5214
α-helix523-5242
α-helix527-5304
β-strand538111
α-helix543-5486
α-helix551-56111
α-helix567-5682
α-helix569-5768
α-helix578-59013
α-helix600-61516

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
LepBA, B, Cprotein302Legionella pneumophila subsp. pneumophilaQ5ZSM7
Sequence of entity 1 (A, B, C), FASTA
>4I1M_1 LepB (chains A, B, C)
EELYQSILELKPLTLLMTSSTSFSETINQWADILKTTDMEKFSFDSNPINLLELVKQFNL
YVDELAITCEANNVWAKERIDSTPNLFALYDNSGGEAIHGHAFVPYYKESIVLRRLFTVD
PNTFNLSRFAAFEGPCQLYCAAHADSAWVKIQTLLTLGNGIINTLKIIKQAQAFGIDEAV
TENLKALKEQFIAFQLAEADIKESLKAPSFAEPLPNKESEFFYPIDEKALAKMNGYQLAT
ICLEELNSPKPSPLIERILSNKKFWKRINSAFESGVFKGRTDDPAGKIAKIREWHQLLQI
SG

Primary citation

Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB. Mihai Gazdag, E., Streller, A., Haneburger, I. et al. EMBO Rep (2013) 14:199-205. DOI 10.1038/embor.2012.211 · PubMed

Other PDB entries of the same protein (UniProt Q5ZSM7), best resolution first:

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