4IG7: Trichinella spiralis UCH37

Crystal structure of Trichinella spiralis UCH37 bound to Ubiquitin vinyl methyl ester. Determined by X-ray diffraction at 2.0 Å resolution. Released 29 May 2013.

Method: X-ray diffraction
Resolution: 2.0 Å
Organisms: Trichinella spiralis, Homo sapiens
Chains: 2
Atoms: 2,536
Mol. weight: 47.45 kDa
Ligands: GVE
Released: 29 May 2013

Explore 4IG7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4IG7 contains 14 α-helices and 15 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 9 β-strands

Element	Residues	Length	Sheet
β-strand	10	1	1
α-helix	13-22	10
β-strand	26	1	2
β-strand	28-33	6	3
α-helix	41-43	3
α-helix	44	1
β-strand	46-54	9	3
α-helix	82-84	3
α-helix	85-94	10
β-strand	103	1	2
α-helix	106-114	9
α-helix	120-129	10
α-helix	131-138	8
β-strand	160-168	9	3
β-strand	171-175	5	3
β-strand	183-187	5	3
α-helix	194-206	13
β-strand	217-223	7	3
α-helix	225-239	15
α-helix	242-261	20

Chain B: 3 helices, 6 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	4
β-strand	12-16	5	4
α-helix	23-34	12
α-helix	38-40	3
β-strand	41-45	5	4
β-strand	48-49	2	4
α-helix	50-51	2
β-strand	66-71	6	4
β-strand	74	1	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Ubiquitin C-terminal hydrolase 37	A	protein	343	Trichinella spiralis	A0ABR3K354
Ubiquitin	B	protein	75	Homo sapiens	F5H388 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4IG7_1 Ubiquitin C-terminal hydrolase 37 (chains A)
MGSSHHHHHHSSGLVPRGSHMASMTGGQQMGRGSMAEGNWCLIESDPGIFTEMIHGFGCT
GLQVEELVVLDESIEHLKPIHGFIFLFRWLKKEMRKEVDDSPQTCTDVYFSQQVIQNACA
SQALINLLLNCDHPDVDLGPTLKEFKDFTYDLDSASRGLCLTNSEKIRAVHNSFGRQQLF
EIDDQQKLDEEDVFHFVTYVPVNDGVYELDGLRAAPLRLGTVASDGDWTEVAIKAIKEKI
KNYGESEVRFNLMAVISDQKLKYEREMEKFAQAGDSAEVDRLVALIAAEDAKRERYAMEA
ARHRHNYVPFIVELLRILAEEEVLSRMLADVSDSNVAHDFVFE

Sequence of entity 2 (B), FASTA

>4IG7_2 Ubiquitin (chains B)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRG

Ligands and cofactors

ID	Name	Formula	Copies
GVE	Methyl 4-aminobutanoate	C5 H11 N O2	1

Primary citation

Stabilization of an Unusual Salt Bridge in Ubiquitin by the Extra C‑Terminal Domain of the Proteasome-Associated Deubiquitinase UCH37 as a Mechanism of Its Exo Speciﬁcity. Morrow, M.E., Kim, M.-I., Ronau, J.A. et al. Biochemistry (2013) 52:3564-3578. DOI 10.1021/bi4003106 · PubMed

Other PDB entries of the same protein (UniProt A0ABR3K354), best resolution first:

4I6N 1.7 Å, Crystal structure of Trichinella spiralis UCH37 catalytic domain bound to Ubiquitin…

Browse structure collections

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