4J15: Aspartate--tRNA ligase, cytoplasmic

Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex. Determined by X-ray diffraction at 2.24 Å resolution. Released 15 May 2013.

Method
X-ray diffraction
Resolution
2.24 Å
Organism
Homo sapiens
Chains
2
Atoms
7,392
Mol. weight
119.51 kDa
Released
15 May 2013

Explore 4J15 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4J15 contains 53 α-helices and 46 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 27 helices, 23 β-strands

ElementResiduesLengthSheet
α-helix26-283
β-strand29-3131
α-helix32-343
β-strand4511
α-helix46-472
α-helix48-503
α-helix53-553
β-strand59-72141
β-strand75-8281
β-strand85-9281
β-strand9312
β-strand9712
α-helix99-1079
α-helix1091
β-strand113-122101
β-strand135-146121
α-helix147-1493
α-helix156-1605
α-helix176-1816
α-helix183-1864
α-helix190-21223
β-strand216-21723
α-helix250-25910
β-strand264-27183
β-strand286-29493
α-helix300-32021
α-helix322-33110
α-helix335-3373
β-strand344-34743
α-helix348-35710
α-helix366-3694
α-helix370-38415
β-strand388-39253
β-strand39514
α-helix396-3983
β-strand40315
α-helix4041
β-strand40516
α-helix4061
β-strand41214
β-strand41316
β-strand415-42063
β-strand423-43083
β-strand43115
α-helix435-44410
α-helix450-4523
α-helix453-4575
β-strand466-47273
α-helix473-4819
α-helix486-4894
Chain B: 26 helices, 23 β-strands
ElementResiduesLengthSheet
α-helix26-283
β-strand29-3137
α-helix32-343
β-strand4517
α-helix46-472
α-helix48-503
α-helix53-553
β-strand59-72147
β-strand75-8287
β-strand85-9287
β-strand9318
β-strand9718
α-helix99-1079
α-helix108-1092
β-strand113-122107
β-strand135-146127
α-helix147-1493
α-helix156-1594
α-helix176-1816
α-helix183-1864
α-helix190-21223
β-strand216-21729
α-helix250-25910
β-strand264-27189
β-strand286-29499
α-helix300-32021
α-helix322-33110
α-helix335-3373
β-strand344-34749
α-helix348-35710
α-helix366-3694
α-helix370-38415
β-strand388-39259
β-strand395110
α-helix396-3983
β-strand403111
α-helix4041
β-strand405112
α-helix4061
β-strand412110
β-strand413112
β-strand415-42069
β-strand423-43089
β-strand431111
α-helix435-44410
α-helix453-4575
β-strand466-47279
α-helix473-4808
α-helix486-4894

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Aspartate--tRNA ligase, cytoplasmicA, Bprotein521Homo sapiensP14868 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4J15_1 Aspartate--tRNA ligase, cytoplasmic (chains A, B)
MGSSHHHHHHSSGLVPRGSHMPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEK
PDRVLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQ
MVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAV
RPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQT
PKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTH
RHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFL
EPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRP
FYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFR
FGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP

Primary citation

Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex. Kim, K.R., Park, S.H., Kim, H.S. et al. Proteins (2013) 81:1840-1846. DOI 10.1002/prot.24306 · PubMed

Other PDB entries of the same protein (UniProt P14868 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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