Voltage-gated sodium channel 1.5 C-terminal domain in complex with FGF12B and Ca2+/calmodulin. Determined by X-ray diffraction at 3.84 Å resolution. Released 21 May 2014.
Explore 4JQ0 in 3D Show helices and sheets RCSB PDB PDBe
4JQ0 contains 19 α-helices and 20 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 13-22 | 10 | 1 |
| β-strand | 26-30 | 5 | 1 |
| β-strand | 36-39 | 4 | 1 |
| α-helix | 45-47 | 3 | |
| β-strand | 48-55 | 8 | 1 |
| β-strand | 58-63 | 6 | 1 |
| β-strand | 68-70 | 3 | 1 |
| β-strand | 80-81 | 2 | 1 |
| α-helix | 86-88 | 3 | |
| β-strand | 90-95 | 6 | 1 |
| β-strand | 99-108 | 10 | 1 |
| β-strand | 115-117 | 3 | 1 |
| β-strand | 120 | 1 | 2 |
| β-strand | 126 | 1 | 2 |
| α-helix | 129-131 | 3 | |
| β-strand | 141-151 | 11 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 8-20 | 13 | |
| α-helix | 30-40 | 11 | |
| α-helix | 46-54 | 9 | |
| α-helix | 66-77 | 12 | |
| α-helix | 87-93 | 7 | |
| β-strand | 100-102 | 3 | 3 |
| α-helix | 103-112 | 10 | |
| α-helix | 116-118 | 3 | |
| α-helix | 119-129 | 11 | |
| β-strand | 136-138 | 3 | 3 |
| α-helix | 139-146 | 8 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1788-1801 | 14 | |
| β-strand | 1808-1810 | 3 | 4 |
| α-helix | 1811-1820 | 10 | |
| α-helix | 1828 | 1 | |
| α-helix | 1832-1837 | 6 | |
| β-strand | 1841-1842 | 2 | 5 |
| β-strand | 1843 | 1 | 4 |
| β-strand | 1847-1849 | 3 | 4 |
| α-helix | 1850-1862 | 13 | |
| α-helix | 1867-1882 | 16 | |
| β-strand | 1894-1895 | 2 | 5 |
| α-helix | 1896-1925 | 30 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Fibroblast growth factor 12 | A | protein | 243 | Homo sapiens | P61328 (AlphaFold model) |
| Calmodulin | C | protein | 149 | Homo sapiens | P0DP23 (AlphaFold model) |
| Sodium channel protein type 5 subunit alpha | D | protein | 191 | Homo sapiens | Q14524 (AlphaFold model) |
>4JQ0_1 Fibroblast growth factor 12 (chains A) MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERHVLGVFSKVRFCSGRKR PVRRRPEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQG VKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKE GQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEIGEKQGRSRKSSGTPTMNGGKVVNQ DST
>4JQ0_2 Calmodulin (chains C) MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE EVDEMIREADIDGDGQVNYEEFVQMMTAK
>4JQ0_3 Sodium channel protein type 5 subunit alpha (chains D) MGSSHHHHHHSSGLVPRGSHMASENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFI EYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMD ALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFR QQAGSGLSEED
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 4 |
Structural analyses of Ca(2+)/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation. Wang, C., Chung, B.C., Yan, H. et al. Nat Commun (2014) 5:4896-4896. DOI 10.1038/ncomms5896 · PubMed
Other PDB entries of the same protein (UniProt P61328 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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