4K6J: Human cohesin inhibitor WapL

Human cohesin inhibitor WapL. Determined by X-ray diffraction at 2.62 Å resolution. Released 19 Jun 2013.

Method
X-ray diffraction
Resolution
2.62 Å
Organism
Homo sapiens
Chains
2
Atoms
7,827
Mol. weight
129.32 kDa
Released
19 Jun 2013

Explore 4K6J in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4K6J contains 58 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 29 helices, 2 β-strands

ElementResiduesLengthSheet
α-helix-1-64012
α-helix652-66413
α-helix671-68414
α-helix688-6969
α-helix700-7067
α-helix710-7123
α-helix714-72714
α-helix738-74912
α-helix765-78016
α-helix786-7883
α-helix791-80212
α-helix810-8178
α-helix820-83617
α-helix841-86222
α-helix866-89732
α-helix912-9132
α-helix917-94125
α-helix945-9528
α-helix957-96610
α-helix968-9714
α-helix974-9763
α-helix977-99216
α-helix996-10038
β-strand1006-100721
β-strand1030-103121
α-helix1032-105827
α-helix1107-113529
α-helix1137-114610
α-helix1148-11503
α-helix1153-116917
α-helix1174-118815
Chain B: 29 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix-1-63911
α-helix652-6554
α-helix657-6637
α-helix671-68414
α-helix688-6969
α-helix700-7067
α-helix710-7123
α-helix714-72714
α-helix738-74811
α-helix763-78018
α-helix786-7883
α-helix791-80212
α-helix810-8189
α-helix820-83516
α-helix841-86121
α-helix866-89429
α-helix895-8973
α-helix922-94120
α-helix945-9528
α-helix957-96610
α-helix969-9713
α-helix974-99219
α-helix996-10038
α-helix1032-105322
α-helix1109-113527
α-helix1137-114610
α-helix1148-11503
α-helix1153-116917
α-helix1174-118815

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Wings apart-like protein homologA, Bprotein568Homo sapiensQ7Z5K2 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4K6J_1 Wings apart-like protein homolog (chains A, B)
GPLGSGRPELYTVVQHVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPLNTRCLSVISLA
TKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAALMYILSRDRLNMDLDRASLD
LMIRLLELEQDASSAKLLNEKDMNKIKEKIRRLCETVHNKHLDLENITTGHLAMETLLSL
TSKRAGDWFKEELRLLGGLDHIVDKVKECVDHLSRDEDEEKLVASLWGAERCLRVLESVT
VHNPENQSYLIAYKDSQLIVSSAKALQHCEELIQQYNRAEDSICLADSKPLPHQNVTNHV
GKAVEDCMRAIIGVLLNLTNDNEWGSTKTGEQDGLIGTALNCVLQVPKYLPQEQRFDIRV
LGLGLLINLVEYSARNRHCLVNMETSCSFDSSICSGEGDDSLRIGGQVHAVQALVQLFLE
RERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVSTEKTDGTEEKHKKEEEDEE
LDLNKALQHAGKHMEDCIVASYTALLLGCLCQESPINVTTVREYLPEGDFSIMTEMLKKF
LSFMNLTCAVGTTGQKSISRVIEYLEHC

Primary citation

Structure of the human cohesin inhibitor Wapl. Ouyang, Z., Zheng, G., Song, J. et al. Proc Natl Acad Sci U S A (2013) 110:11355-11360. DOI 10.1073/pnas.1304594110 · PubMed

Other PDB entries of the same protein (UniProt Q7Z5K2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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