4M1K: Elongation factor G

Crystal structure of elongation factor G (EFG). Determined by X-ray diffraction at 2.95 Å resolution. Released 6 Aug 2014.

Method: X-ray diffraction
Resolution: 2.95 Å
Organism: Thermus thermophilus
Chains: 1
Atoms: 5,133
Mol. weight: 77.43 kDa
Ligands: MG, GDP
Released: 6 Aug 2014

Explore 4M1K in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4M1K contains 28 α-helices and 43 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 28 helices, 43 β-strands

Element	Residues	Length	Sheet
α-helix	9-11	3
β-strand	12-18	7	1
α-helix	25-35	11
β-strand	69-74	6	1
β-strand	77-82	6	1
α-helix	91-98	8
β-strand	103-109	7	1
β-strand	113	1	1
α-helix	116-127	12
β-strand	132-137	6	1
α-helix	146-157	12
β-strand	161-163	3	1
β-strand	165-168	4	2
β-strand	176-179	4	2
β-strand	184-188	5	2
β-strand	196-199	4	2
α-helix	200-202	3
α-helix	203-205	3
α-helix	206-220	15
α-helix	225-232	8
α-helix	235-238	4
α-helix	239-251	13
β-strand	256-260	5	1
β-strand	262	1	3
β-strand	267	1	3
α-helix	269-279	11
α-helix	281-282	2
α-helix	287-289	3
β-strand	290-292	3	4
β-strand	298-300	3	4
β-strand	310-319	10	5
β-strand	323-332	10	5
β-strand	335-336	2	6
β-strand	340-343	4	5
β-strand	348-358	11	5
β-strand	363-366	4	5
β-strand	368-369	2	6
β-strand	374-379	6	5
α-helix	387	1
β-strand	388-390	3	5
β-strand	398	1	4
α-helix	404-406	3
β-strand	409-412	4	7
β-strand	413-414	2	8
α-helix	421-431	11
β-strand	439-442	4	7
β-strand	449-453	5	7
α-helix	456-467	12
β-strand	475-476	2	8
β-strand	480-481	2	7
β-strand	484-486	3	9
β-strand	491-499	9	10
β-strand	506-516	11	10
α-helix	517	1
β-strand	523-527	5	10
α-helix	539-549	11
α-helix	558-559	2
β-strand	560	1	9
β-strand	563-571	9	10
β-strand	577	1	10
α-helix	579-596	18
β-strand	600-613	14	9
α-helix	614-616	3
α-helix	617-626	10
β-strand	630-635	6	9
β-strand	640-648	9	9
α-helix	649-651	3
α-helix	655-660	6
β-strand	668-678	11	9
α-helix	679-680	2
α-helix	681-687	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Elongation factor G	A	protein	691	Thermus thermophilus	P13551 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4M1K_1 Elongation factor G (chains A)
MAVKVEYDLKRLRNIGIAAHIDAGKTTTTERILYYTGRIHKIGEVHEGAATMDFMEQERE
RGITITAAVTTCFWKDHRINIIDTPGHVDFTIEVERSMRVLDGAIVVFDSSQGVEPQSET
VWRQAEKYKVPRIAFANKMDKTGADLWLVIRTMQERLGARPVVMQLPIGREDTFSGIIDV
LRMKAYTYGNDLGTDIREIPIPEEYLDQAREYHEKLVEVAADFDENIMLKYLEGEEPTEE
ELVAAIRKGTIDLKITPVFLGSALKNKGVQLLLDAVVDYLPSPLDIPPIKGTTPEGEVVE
IHPDPNGPLAALAFKIMADPYVGRLTFIRVYSGTLTSGSYVYNTTKGRKERVARLLRMHA
NHREEVEELKAGDLGAVVGLKETITGDTLVGEDAPRVILESIEVPEPVIDVAIEPKTKAD
QEKLSQALARLAEEDPTFRVSTHPETGQTIISGMGELHLEIIVDRLKREFKVDANVGKPQ
VAYRETITKPVDVEGKFIRLTGGRGQYGHVKIKVEPLPRGSGFEFVNAIVGGVIPKEYIP
AVQKGIEEAMQSGPLIGFPVVDIKVTLYDGSYHEVDSSEMAFKIAGSMAIKEAVQKGDPV
ILEPIMRVEVTTPEEYMGDVIGDLNARRGQILGMEPRGNAQVIRAFVPLAEMFGYATDLR
SKTQGRGSFVMFFDHYQEVPKQVQEKLIKGQ

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
GDP	Guanosine-5'-diphosphate	C10 H15 N5 O11 P2	1

Primary citation

Crystal structure of elongation factor G (EFG). Liu, G., Dong, J., Gong, W. et al. To be published.

Other PDB entries of the same protein (UniProt P13551 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2BM0 2.4 Å, Ribosomal elongation factor G (EF-G) Fusidic acid resistant mutant T84A
2BV3 2.5 Å, Crystal structure of a mutant elongation factor G trapped with a GTP analogue
2BM1 2.6 Å, Ribosomal elongation factor G (EF-G) Fusidic acid resistant mutant G16V
1FNM 2.8 Å, Structure of thermus thermophilus ef-G H573A
2J7K 2.9 Å, Crystal structure of the T84A mutant EF-G:GDPCP complex
4MYU 3.0 Å, Crystal structure of elongation factor G mutant(EFG)
4MYT 3.5 Å, Crystal structure of elongation factor G (EFG)
1KTV 3.8 Å, Crystal Structure of Elongation Factor G Dimer Without Nucleotide
1PN6 10.8 Å, Domain-wise fitting of the crystal structure of T.thermophilus EF-G into the low…
2BCW 11.2 Å, Coordinates of the N-terminal domain of ribosomal protein L11,C-terminal domain of…
1JQM 18.0 Å, Fitting of L11 protein and elongation factor G (EF-G) in the cryo-em map of e. coli 70S…
1JQS 18.0 Å, Fitting of L11 protein and elongation factor G (domain G' and V) in the cryo-em map of…

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