4N73: Ligand binding domain (LBD) of REV-ERB beta

Crystal structure of the ligand binding domain (LBD) of REV-ERB beta bound to Cobalt Protoporphyrin IX. Determined by X-ray diffraction at 1.87 Å resolution. Released 4 Jun 2014.

Method: X-ray diffraction
Resolution: 1.87 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,840
Mol. weight: 23.07 kDa
Ligands: COH
Released: 4 Jun 2014

Explore 4N73 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4N73 contains 9 α-helices and 3 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	398-420	23
α-helix	424-428	5
α-helix	431-449	19
α-helix	451-453	3
β-strand	454-455	2	1
β-strand	460-462	3	1
β-strand	468-470	3	1
α-helix	471-476	6
α-helix	481-495	15
α-helix	500-512	13
α-helix	522-543	22
α-helix	549-573	25

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Nuclear receptor subfamily 1 group D member 2	A	protein	199	Homo sapiens	Q14995 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4N73_1 Nuclear receptor subfamily 1 group D member 2 (chains A)
GHLVCPMSKSPYVDPHKSGHEIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLK
AGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLLNSMFEFSEKLNALQLS
DEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPNEASIFTKLLLKLP
DLRSLNNMHSEELLAFKVH

Ligands and cofactors

ID	Name	Formula	Copies
COH	Protoporphyrin IX containing co	C34 H32 Co N4 O4	1

Primary citation

Structure of REV-ERB beta Ligand-binding Domain Bound to a Porphyrin Antagonist. Matta-Camacho, E., Banerjee, S., Hughes, T.S. et al. J Biol Chem (2014) 289:20054-20066. DOI 10.1074/jbc.M113.545111 · PubMed

Other PDB entries of the same protein (UniProt Q14995 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3CQV 1.9 Å, Crystal structure of Reverb beta in complex with heme
6WMS 2.0 Å, Crystal Structure of Human REV-ERBbeta Ligand Binding Domain Co-Bound to Heme and NCoR…
2V0V 2.4 Å, Crystal Structure of Rev-Erb beta
2V7C 2.4 Å, Crystal Structure of Rev-Erb beta
6WMQ 2.55 Å, Crystal Structure of Human REV-ERBbeta Ligand Binding Domain Co-Bound to Heme and NCoR…

Browse structure collections

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