Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4. Determined by X-ray diffraction at 2.78 Å resolution. Released 29 Apr 2015.
Explore 4PK4 in 3D Show helices and sheets RCSB PDB PDBe
4PK4 contains 48 α-helices and 30 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 7-11 | 5 | 1 |
| β-strand | 15-24 | 10 | 1 |
| β-strand | 28-33 | 6 | 1 |
| β-strand | 41-44 | 4 | 1 |
| α-helix | 45-47 | 3 | |
| β-strand | 49-50 | 2 | 1 |
| β-strand | 61 | 1 | 2 |
| α-helix | 62-64 | 3 | |
| α-helix | 70-82 | 13 | |
| β-strand | 87-90 | 4 | 2 |
| β-strand | 93-97 | 5 | 2 |
| α-helix | 109-114 | 6 | |
| α-helix | 118-119 | 2 | |
| α-helix | 127-141 | 15 | |
| β-strand | 145-150 | 6 | 2 |
| α-helix | 157-172 | 16 | |
| α-helix | 177-183 | 7 | |
| α-helix | 186-193 | 8 | |
| β-strand | 194-195 | 2 | 3 |
| β-strand | 203-204 | 2 | 3 |
| β-strand | 207-214 | 8 | 2 |
| β-strand | 220-228 | 9 | 2 |
| α-helix | 233-236 | 4 | |
| β-strand | 245 | 1 | 3 |
| α-helix | 246-254 | 9 | |
| α-helix | 257-263 | 7 | |
| α-helix | 268-270 | 3 | |
| α-helix | 272-275 | 4 | |
| α-helix | 280-281 | 2 | |
| β-strand | 282 | 1 | 4 |
| α-helix | 286-290 | 5 | |
| α-helix | 293-295 | 3 | |
| α-helix | 298-303 | 6 | |
| α-helix | 305 | 1 | |
| β-strand | 306 | 1 | 4 |
| α-helix | 307 | 1 | |
| α-helix | 315-326 | 12 | |
| α-helix | 331-349 | 19 | |
| β-strand | 352-354 | 3 | 5 |
| β-strand | 362-364 | 3 | 5 |
| α-helix | 366-368 | 3 | |
| α-helix | 369-378 | 10 | |
| α-helix | 383-391 | 9 | |
| β-strand | 392 | 1 | 6 |
| β-strand | 410 | 1 | 6 |
| α-helix | 413-440 | 28 | |
| β-strand | 450-456 | 7 | 2 |
| α-helix | 468-484 | 17 | |
| α-helix | 485-490 | 6 | |
| α-helix | 491-499 | 9 | |
| α-helix | 503-505 | 3 | |
| α-helix | 512-519 | 8 | |
| α-helix | 525-533 | 9 | |
| α-helix | 540-548 | 9 | |
| β-strand | 558 | 1 | 7 |
| α-helix | 560-562 | 3 | |
| α-helix | 567-570 | 4 | |
| α-helix | 573-575 | 3 | |
| β-strand | 576-581 | 6 | 7 |
| β-strand | 584-589 | 6 | 7 |
| α-helix | 593-596 | 4 | |
| β-strand | 598 | 1 | 8 |
| α-helix | 603-610 | 8 | |
| α-helix | 615-620 | 6 | |
| β-strand | 642 | 1 | 8 |
| α-helix | 643-660 | 18 | |
| β-strand | 662-669 | 8 | 2 |
| α-helix | 682-691 | 10 | |
| α-helix | 694-701 | 8 | |
| β-strand | 707-710 | 4 | 9 |
| α-helix | 711-718 | 8 | |
| α-helix | 719-721 | 3 | |
| α-helix | 724-728 | 5 | |
| α-helix | 731-739 | 9 | |
| β-strand | 749-751 | 3 | 9 |
| β-strand | 755-758 | 4 | 9 |
| α-helix | 763-769 | 7 | |
| α-helix | 774-787 | 14 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Unconventional myosin-VI | A | protein | 788 | Sus scrofa | F1RQI7 (AlphaFold model) |
>4PK4_1 Unconventional myosin-VI (chains A) EDGKPVWAPHPTDGFQVGNIVDIGPDSLTIEPLNQKGKTFLALINQVFPAEEDSKKDVED NCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFDIPKIYSSETIKSYQGKSLG TMPPHVFAIADKAFRDMKVLKLSQSIIVSGESGAGKTENTKFVLRYLTESYGTGQDIDDR IVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVGGFVSHYLLEKSRICVQGKE ERNYHIFYRLCAGASEDIRERLHLSSPDNFRYLNRGCTRYFANKETDKQILQNRKSPEYL KAGSLKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVLHLGNIDFEEAGSTSGG CNLKNKSTQALEYCAELLGLDQDDLRVSLTTRVMLTTAGGAKGTVIKVPLKVEQANNARD ALAKTVYSHLFDHVVNRVNQCFPFETSSYFIGVLDIAGFEYFEHNSFEQFCINYCNEKLQ QFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEARLVGILDILDEENRLPQPSDQ HFTSAVHQKHKDHFRLSIPRKSKLAIHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDAL HMSLESLICESRDKFIRELFESSTNNNKDTKQKAGKLSFISVGNKFKTQLNLLLDKLRST GASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRASFHELYNMYKKY MPDKLARLDPRLFCKALFKALGLNEIDYKFGLTKVFFRPGKFAEFDQIMKSDPDHLAELV KRVNHWLI
| ID | Name | Formula | Copies |
|---|---|---|---|
| PO4 | Phosphate ion | O4 P | 1 |
| MG | Magnesium ion | Mg | 1 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 1 |
How actin initiates the motor activity of Myosin. Llinas, P., Isabet, T., Song, L. et al. Dev Cell (2015) 33:401-412. DOI 10.1016/j.devcel.2015.03.025 · PubMed
Other PDB entries of the same protein (UniProt F1RQI7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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