4RWT: Actin-Lmod complex

Structure of actin-Lmod complex. Determined by X-ray diffraction at 2.98 Å resolution. Released 14 Oct 2015.

Method

X-ray diffraction

Resolution

2.98 Å

Organisms

Drosophila melanogaster, Homo sapiens

Chains

4

Atoms

9,317

Mol. weight

200.34 kDa

Ligands

ANP, MG

Released

14 Oct 2015

Explore 4RWT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4RWT contains 67 α-helices and 52 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 23 helices, 20 β-strands

Molecules and chains

>4RWT_1 Actin-5C (chains A, B)
MCDEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQ
SKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKM
TQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLD
LAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKS
YELPDGQVITIGNERFRCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIREDLYANTVL
SGGTTMYPGIADRMQKEITALAKSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISK
QEYDESGPSIVHRKCFASHHHHHH

>4RWT_2 Leiomodin-2 (chains C, D)
MAHHHHHHVGTMSTFGYRRGLSKYESIDEDELLASLSAEELKELERELEDIEPDRNLPVG
LRQKSLTEKTPTGTFSREALMAYWEKESQKLLEKERLGECGKVAEDKEEEEDSDEEERTI
ETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSNGRNTESPAAIHPCGNPTVIED
ALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNTVVKTFSLANTHADDSAAMAIA
EMLKVNEHITNVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKL
LKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRLQEQKQQEGYDGGPNLRTKVWQ
RGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVATPPPPPPPPLPEKKLITRNIAE
VIKQQESAQRALQNGQGSGSGGSVGSQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSA
HENLMEAIRGSSIKQLKRVEVPEALR

Ligands and cofactors

Primary citation

Mechanisms of leiomodin 2-mediated regulation of actin filament in muscle cells. Chen, X., Ni, F., Kondrashkina, E. et al. Proc Natl Acad Sci U S A (2015) 112:12687-12692. DOI 10.1073/pnas.1512464112 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P10987 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 2HF3 1.8 Å, Crystal structure of monomeric Actin in the ADP bound state
• 2HF4 1.8 Å, Crystal structure of Monomeric Actin in its ATP-bound state
• 3EKS 1.8 Å, Crystal Structure of Monomeric Actin bound to Cytochalasin D
• 3MN6 2.0 Å, Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation
• 3MN7 2.0 Å, Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation
• 3MN9 2.0 Å, Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation
• 3EKU 2.5 Å, Crystal Structure of Monomeric Actin bound to Cytochalasin D
• 3EL2 2.5 Å, Crystal Structure of Monomeric Actin Bound to Ca-ATP
• 4M63 2.75 Å, Crystal Structure of a Filament-Like Actin Trimer Bound to the Bacterial Effector VopL
• 3MMV 2.8 Å, Structures of actin-bound WH2 domains of Spire and the implication for filament nucleation
• 4JHD 2.91 Å, Crystal Structure of an Actin Dimer in Complex with the Actin Nucleator Cordon-Bleu
• 5WFN 3.0 Å, Revised model of leiomodin 2-mediated actin regulation (alternate refinement of PDB 4RWT)

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