4TRG: The SNL domain of SidC

the SNL domain of SidC. Determined by X-ray diffraction at 2.59 Å resolution. Released 2 Jul 2014.

Method
X-ray diffraction
Resolution
2.59 Å
Organism
Legionella pneumophila
Chains
2
Atoms
8,608
Mol. weight
125.35 kDa
Ligands
HG
Released
2 Jul 2014

Explore 4TRG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4TRG contains 67 α-helices and 40 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 35 helices, 20 β-strands

ElementResiduesLengthSheet
α-helix9-113
β-strand20-2231
β-strand28-3031
β-strand31-3662
β-strand3713
β-strand4014
β-strand4113
α-helix45-473
α-helix50-578
β-strand59-6135
β-strand64-6635
α-helix69-8820
α-helix90-934
α-helix99-12426
α-helix134-1374
α-helix141-1444
α-helix145-1528
β-strand157-16154
β-strand17814
α-helix1831
β-strand18416
α-helix1851
α-helix186-1883
α-helix1951
β-strand19616
α-helix197-1982
α-helix202-2109
α-helix216-2172
β-strand218-21927
α-helix225-23410
α-helix248-26821
α-helix272-2765
β-strand28118
β-strand28718
α-helix290-2912
α-helix292-2965
α-helix306-31712
α-helix320-3234
α-helix324-3296
β-strand337-33827
α-helix341-36424
α-helix372-3776
α-helix381-39414
α-helix399-40810
α-helix412-4143
α-helix419-4213
α-helix422-43918
β-strand447-45154
β-strand459-46242
β-strand465-46952
α-helix470-4778
α-helix485-4873
α-helix490-4956
β-strand50112
α-helix507-5104
Chain B: 32 helices, 20 β-strands
ElementResiduesLengthSheet
β-strand20-2239
β-strand28-3039
β-strand31-36610
β-strand37111
β-strand40112
β-strand41111
α-helix45-473
α-helix50-578
β-strand59-61313
β-strand64-66313
α-helix69-9325
α-helix99-12426
α-helix133-1375
α-helix145-1528
β-strand157-161512
β-strand178112
α-helix1831
β-strand184114
α-helix1851
α-helix186-1883
α-helix1951
β-strand196114
α-helix197-1982
α-helix202-2109
α-helix2171
β-strand218-219215
α-helix225-23410
α-helix248-26821
α-helix272-2765
β-strand281116
β-strand287116
α-helix290-2912
α-helix292-2965
α-helix306-31712
α-helix320-3234
α-helix324-3296
β-strand337-338215
α-helix341-36424
α-helix372-3776
α-helix381-39515
α-helix399-40810
α-helix412-4143
α-helix419-4213
α-helix422-43918
β-strand447-451512
β-strand459-462410
β-strand465-469510
α-helix470-4778
α-helix485-4873
α-helix490-4956
β-strand501-502210
α-helix507-5148

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
SidCA, Bprotein542Legionella pneumophilaQ6RCR4 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4TRG_1 SidC (chains A, B)
MVINMVDVIKFKEPERCDYLYVDENNKVHILLPIVGGDEIGLDNTCQTAVELITFFYGSA
HSGVTKYSAEHQLSEYKRQLEEDIKAINSQKKISPHAYDDLLKEKIERLQQIEKYIELIQ
VLKKQYDEQNDIRQLRTGGIPQLPSGVKEIIKSSENAFAVRLSPYDNDKFTRFDDPLFNV
KRNISKYDTPSRQAPIPIYEGLGYRLRSTLFPEDKTPTPINKKSLRDKVKSTVLSHYKDE
DRIDGEKKDEKLNELITNLQNELVKELVKSDPQYSKLSLSKDPRGKEINYDYLVNSLMLV
DNDSEIGDWIDTILDATVDSTVWVAQASSPFYDGAKEISSDRDADKISIRVQYLLAEANI
YCKTNKLSDANFGEFFDKEPHATEIAKRVKEGFTQGADIEPIIYDYINSNHAELGLKSPL
TGKQQQEITDKFTKHYNTIKESPHFDEFFVADPDKKGNIFSHQGRISCHFLDFFTRQTKG
KHPLGDLASHQEALQEGTSNRLHHKNEVVAQGYEKLDQFKKEVVKLLAENKPKELLDYLV
AT

Ligands and cofactors

IDNameFormulaCopies
HGMercury (II) ionHg4

Primary citation

The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling. Hsu, F., Luo, X., Qiu, J. et al. Proc Natl Acad Sci U S A (2014) 111:10538-10543. DOI 10.1073/pnas.1402605111 · PubMed

Other PDB entries of the same protein (UniProt Q6RCR4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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