4U21: GluA2flip sLBD

GluA2flip sLBD complexed with FW and (R,R)-2b crystal form E. Determined by X-ray diffraction at 1.39 Å resolution. Released 20 Aug 2014.

Method: X-ray diffraction
Resolution: 1.39 Å
Organism: Rattus norvegicus
Chains: 2
Atoms: 4,865
Mol. weight: 59.19 kDa
Ligands: FWD, FWF
Released: 20 Aug 2014

Explore 4U21 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4U21 contains 32 α-helices and 38 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 16 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	5	1
β-strand	6-10	5	1
β-strand	18-19	2	2
α-helix	23-25	3
α-helix	28-31	4
β-strand	32-33	2	2
α-helix	35-47	13
β-strand	51-55	5	1
β-strand	64	1	3
β-strand	71	1	3
α-helix	73-79	7
β-strand	85-86	2	1
β-strand	91	1	4
α-helix	94-97	4
β-strand	100-102	3	1
α-helix	103	1
α-helix	105	1
β-strand	107-109	3	4
β-strand	111-116	6	5
α-helix	124-128	5
β-strand	134-136	3	5
β-strand	138	1	6
α-helix	142-149	8
α-helix	153-164	12
β-strand	171	1	6
α-helix	174-183	10
β-strand	188-193	6	5
α-helix	194-200	7
β-strand	208-211	4	5
β-strand	218-220	3	4
β-strand	223-225	3	1
α-helix	231-244	14
α-helix	246-251	6
α-helix	252-256	5

Chain B: 16 helices, 20 β-strands

Element	Residues	Length	Sheet
α-helix	5	1
β-strand	6-10	5	7
β-strand	13	1	8
β-strand	17	1	8
β-strand	18-19	2	9
α-helix	20	1
α-helix	23-25	3
α-helix	28-31	4
β-strand	32-33	2	9
α-helix	35-47	13
β-strand	51-55	5	7
β-strand	64	1	10
β-strand	71	1	10
α-helix	73-79	7
β-strand	85-86	2	7
β-strand	91	1	11
α-helix	94-97	4
β-strand	100-102	3	7
α-helix	103	1
α-helix	105	1
β-strand	107-109	3	11
β-strand	111-116	6	12
α-helix	124-128	5
β-strand	134-136	3	12
β-strand	138	1	13
α-helix	142-149	8
α-helix	153-164	12
β-strand	171	1	13
α-helix	174-183	10
β-strand	188-193	6	12
α-helix	194-201	8
β-strand	208-211	4	12
β-strand	218-220	3	11
β-strand	223-225	3	7
α-helix	231-244	14
α-helix	246-254	9

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Glutamate receptor 2,Glutamate receptor 2	A, B	protein	262	Rattus norvegicus	P19491 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>4U21_1 Glutamate receptor 2,Glutamate receptor 2 (chains A, B)
ANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKY
GARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKGTPI
ESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARV
RKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGTPVNLAVLKL
SEQGVLDKLKNKWWYDKGECGS

Ligands and cofactors

ID	Name	Formula	Copies
FWD	2-amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-propionic acid	C7 H8 F N3 O4	2
FWF	N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide	C24 H36 N2 O4 S2	1

Primary citation

Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Durr, K.L., Chen, L., Stein, R.A. et al. Cell (2014) 158:778-792. DOI 10.1016/j.cell.2014.07.023 · PubMed

Other PDB entries of the same protein (UniProt P19491 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6YK4 1.0 Å, Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the…
5NG9 1.15 Å, Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist…
6YK5 1.15 Å, Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the…
6YK3 1.2 Å, Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the…
5JEI 1.23 Å, Crystal structure of the GluA2 LBD in complex with FW
4IGT 1.24 Å, Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist…
4YU0 1.26 Å, Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with…
5NIH 1.3 Å, Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist…
1MQI 1.35 Å, Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with…
5FTI 1.35 Å, Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (lithium form)
4FAT 1.4 Å, Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an…
6FAZ 1.4 Å, Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the…

Browse structure collections

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