4UX9: JNK1

Crystal structure of JNK1 bound to a MKK7 docking motif. Determined by X-ray diffraction at 2.34 Å resolution. Released 25 Mar 2015.

Method

X-ray diffraction

Resolution

2.34 Å

Organism

HOMO SAPIENS

Chains

8

Atoms

11,697

Mol. weight

177.52 kDa

Ligands

ANP

Released

25 Mar 2015

Explore 4UX9 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4UX9 contains 100 α-helices and 56 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 24 helices, 15 β-strands

Molecules and chains

>4UX9_1 MITOGEN-ACTIVATED PROTEIN KINASE 8 (chains A, B, C, D)
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLE

>4UX9_2 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7 (chains F, G, H, I)
QRPRPTLQLPLA

Ligands and cofactors

Water and common crystallization additives (SO4) are not listed.

Primary citation

Structure and Dynamics of the Mkk7-Jnk Signaling Complex. Kragelj, J., Palencia, A., Nanao, M.H. et al. Proc Natl Acad Sci U S A (2015) 112:3409. DOI 10.1073/PNAS.1419528112 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P45983 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 2XRW 1.33 Å, Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear…
• 12CV 1.5 Å, Crystal Structure of human JNK1 Kinase Domain in complex with inhibitor CCD-2728
• 4QTD 1.5 Å, Structure of human JNK1 in complex with SCH772984 and the AMPPNP-hydrolysed triphosphate…
• 11ZL 1.55 Å, Crystal Structure of human JNK1 Kinase Domain in complex with inhibitor CCD-3013
• 8R5E 1.7 Å, JNK1 covalently bound to RU77 cyclohexenone based inhibitor
• 3ELJ 1.8 Å, Jnk1 complexed with a bis-anilino-pyrrolopyrimidine inhibitor.
• 4AWI 1.91 Å, Human Jnk1alpha kinase with 4-phenyl-7-azaindole IKK2 inhibitor.
• 4L7F 1.95 Å, Co-crystal Structure of JNK1 and AX13587
• 3PZE 2.0 Å, JNK1 in complex with inhibitor
• 8X5M 2.0 Å, The Crystal Structure of JNK1 from Biortus.
• 4HYU 2.15 Å, Crystal structure of JNK1 in complex with JIP1 peptide and…
• 4E73 2.27 Å, Crystal structure of JNK1beta-JIP in complex with an azaquinolone inhbitor

Browse structure collections

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