Crystal Structure of mUCH37-hRPN13 CTD-hUb complex. Determined by X-ray diffraction at 2.0 Å resolution. Released 4 Mar 2015.
Explore 4WLR in 3D Show helices and sheets RCSB PDB PDBe
4WLR contains 29 α-helices and 22 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 11-12 | 2 | 1 |
| α-helix | 15-24 | 10 | |
| β-strand | 28 | 1 | 2 |
| β-strand | 30-34 | 5 | 1 |
| α-helix | 41-44 | 4 | |
| β-strand | 49-57 | 9 | 1 |
| α-helix | 62-64 | 3 | |
| β-strand | 67-68 | 2 | 1 |
| α-helix | 69 | 1 | |
| α-helix | 72-75 | 4 | |
| α-helix | 88-97 | 10 | |
| β-strand | 106 | 1 | 2 |
| α-helix | 108-118 | 11 | |
| α-helix | 123-131 | 9 | |
| α-helix | 134-142 | 9 | |
| β-strand | 163-171 | 9 | 1 |
| β-strand | 174-178 | 5 | 1 |
| β-strand | 186-190 | 5 | 1 |
| β-strand | 192 | 1 | 3 |
| β-strand | 195 | 1 | 3 |
| α-helix | 197-209 | 13 | |
| β-strand | 219-225 | 7 | 1 |
| α-helix | 227-244 | 18 | |
| α-helix | 255-288 | 34 | |
| α-helix | 292-304 | 13 | |
| α-helix | 308-317 | 10 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 288-291 | 4 | |
| α-helix | 294-297 | 4 | |
| α-helix | 300-302 | 3 | |
| α-helix | 304-310 | 7 | |
| α-helix | 311-313 | 3 | |
| β-strand | 317 | 1 | 4 |
| β-strand | 320 | 1 | 4 |
| α-helix | 324-326 | 3 | |
| α-helix | 327-332 | 6 | |
| α-helix | 334-348 | 15 | |
| α-helix | 353-358 | 6 | |
| α-helix | 363-371 | 9 | |
| α-helix | 374-383 | 10 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 2-7 | 6 | 5 |
| β-strand | 12-16 | 5 | 5 |
| β-strand | 22 | 1 | 6 |
| α-helix | 23-34 | 12 | |
| α-helix | 38-40 | 3 | |
| β-strand | 41-45 | 5 | 5 |
| β-strand | 48-49 | 2 | 5 |
| α-helix | 50-51 | 2 | |
| β-strand | 55 | 1 | 6 |
| α-helix | 57-59 | 3 | |
| β-strand | 66-71 | 6 | 5 |
| β-strand | 74-75 | 2 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase isozyme L5 | A | protein | 328 | Mus musculus | Q9WUP7 (AlphaFold model) |
| Proteasomal ubiquitin receptor ADRM1 | B | protein | 102 | Homo sapiens | Q16186 (AlphaFold model) |
| Polyubiquitin-B | C | protein | 76 | Homo sapiens | P0CG47 (AlphaFold model) |
>4WLR_1 Ubiquitin carboxyl-terminal hydrolase isozyme L5 (chains A) MSSNAGEWCLMESDPGVFTELIKGFGCRGAQVEEIWSLEPESFEKLKPVHGLIFLFKWQP GEEPAGSVVQDSRLETIFFAKQVINNACATQAIVSVLLNCTHQDVHLGETLSEFKEFSQS FDAAMKGLALSNSDVIRQVHNSFARQQMFEFDTKTPAKEEDAFHFVSYVPVNGRLYELDG LREGPIDLGACNQDDWITAVRPVIEKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQR QLAEEPMDTDQGSTVLSAIQSEVARNQMLIEEEVQKLKRYKIENIRRKHNYLPFIMELLK TLAEHQQLIPLVEKAKEKQNAKKAQETK
>4WLR_2 Proteasomal ubiquitin receptor ADRM1 (chains B) QVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFS AALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAK
>4WLR_3 Polyubiquitin-B (chains C) MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN IQKESTLHLVLRLRGG
Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase. VanderLinden, R.T., Hemmis, C.W., Schmitt, B. et al. Mol Cell (2015) 57:901-911. DOI 10.1016/j.molcel.2015.01.016 · PubMed
Other PDB entries of the same protein (UniProt Q9WUP7 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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