4WTH: Ataxin-3 Carboxy Terminal Region - Crystal C2

Ataxin-3 Carboxy Terminal Region - Crystal C2 (triclinic). Determined by X-ray diffraction at 2.25 Å resolution. Released 9 Mar 2016.

Method: X-ray diffraction
Resolution: 2.25 Å
Organisms: Escherichia coli, Homo sapiens
Chains: 2
Atoms: 6,458
Mol. weight: 98.23 kDa
Ligands: ZN
Released: 9 Mar 2016

Explore 4WTH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4WTH contains 46 α-helices and 48 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 23 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	6-10	5	1
α-helix	17-31	15
β-strand	34-38	5	1
α-helix	43-50	8
β-strand	59-63	5	1
α-helix	64-66	3
α-helix	67-72	6
β-strand	76	1	2
α-helix	77-79	3
α-helix	83-86	4
β-strand	89	1	3
α-helix	91-96	6
β-strand	98-99	2	4
β-strand	102-103	2	4
β-strand	106-111	6	1
β-strand	114-118	5	5
β-strand	128	1	6
α-helix	132-140	9
β-strand	145-147	3	5
α-helix	154-163	10
β-strand	167-172	6	7
β-strand	175-182	8	7
α-helix	186-200	15
α-helix	210-219	10
β-strand	222-227	6	5
α-helix	229-231	3
α-helix	232-238	7
β-strand	242-245	4	5
α-helix	246-248	3
β-strand	249	1	6
β-strand	250	1	8
β-strand	253	1	8
α-helix	254-255	2
β-strand	258-259	2	9
β-strand	260-266	7	1
β-strand	267	1	2
α-helix	273-279	7
α-helix	280-284	5
α-helix	287-296	10
β-strand	301-302	2	1
β-strand	304	1	3
α-helix	305-310	6
α-helix	315-326	12
β-strand	328-329	2	9
α-helix	330-331	2
α-helix	336-351	16
α-helix	357-396	40

Chain B: 23 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	7-10	4	10
α-helix	17-31	15
β-strand	35-38	4	10
α-helix	43-51	9
β-strand	59-63	5	10
α-helix	64-66	3
α-helix	67-72	6
β-strand	76	1	11
α-helix	77-79	3
α-helix	83-86	4
β-strand	89	1	12
α-helix	91-95	5
β-strand	98-99	2	13
β-strand	102-103	2	13
β-strand	106-111	6	10
β-strand	114-118	5	14
β-strand	128	1	15
α-helix	132-140	9
β-strand	145-147	3	14
α-helix	154-163	10
β-strand	167-172	6	16
β-strand	175-182	8	16
α-helix	186-200	15
α-helix	210-218	9
β-strand	222-227	6	14
α-helix	229-231	3
α-helix	232-238	7
β-strand	242-245	4	14
α-helix	246-248	3
β-strand	249	1	15
β-strand	250	1	17
β-strand	253	1	17
α-helix	254-255	2
β-strand	258-259	2	18
β-strand	260-266	7	10
β-strand	267	1	11
α-helix	273-279	7
α-helix	280-284	5
α-helix	287-296	10
β-strand	301-302	2	10
β-strand	304	1	12
α-helix	305-310	6
α-helix	315-326	12
β-strand	328-329	2	18
α-helix	330-331	2
α-helix	336-351	16
α-helix	357-396	40

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Maltose-binding periplasmic protein, Ataxin-3 chimera	A, B	protein	441	Escherichia coli, Homo sapiens	P0AEX9 (AlphaFold model), P54252 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>4WTH_1 Maltose-binding periplasmic protein, Ataxin-3 chimera (chains A, B)
KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDII
FWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKD
LLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKD
VGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKV
NYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEA
LKDAQTNAAASEELRKRREAYFEKQQQKQQQQQQQQQQGDLSGQSSHPCERPATSSGSLG
SDQSYQITAGKLGTGRRFTTS

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	6

Primary citation

The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3. Zhemkov, V.A., Kulminskaya, A.A., Bezprozvanny, I.B. et al. FEBS Open Bio (2016) 6:168-178. DOI 10.1002/2211-5463.12029 · PubMed

Other PDB entries of the same protein (UniProt P0AEX9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8C8F 1.15 Å, Crystal structure of the E. coli maltodextrin-binding protein
4EXK 1.28 Å, A chimera protein containing MBP fused to the C-terminal domain of the uncharacterized…
3Q27 1.3 Å, Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (MBP)
7KD4 1.31 Å, Structure of the C-terminal domain of the Menangle virus phosphoprotein (residues 329…
5M13 1.37 Å, Synthetic nanobody in complex with MBP
5HZ7 1.43 Å, High-resolution crystal structure of the minor DNA-binding pilin ComP from Neisseria…
5H7Q 1.45 Å, Crystal structure of human MNDA PYD domain with MBP tag
6XDS 1.47 Å, Crystal structure of MBP-TREM2 Ig domain fusion with fragment,…
4IRL 1.47 Å, X-ray structure of the CARD domain of zebrafish GBP-NLRP1 like protein
8SVY 1.47 Å, MBP-Mcl1 in complex with ligand 10
3MP6 1.48 Å, Complex Structure of Sgf29 and dimethylated H3K4
9CLC 1.48 Å, Crystal structure of maltose binding protein (Apo), mutant Trp10 to 4-Cyanotryptophan

Browse structure collections

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