Selection of fragments for kinase inhibitor design: decoration is key. Determined by X-ray diffraction at 1.8 Å resolution. Released 24 Dec 2014.
Explore 4X2N in 3D Show helices and sheets RCSB PDB PDBe
4X2N contains 18 α-helices and 19 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 202-204 | 3 | |
| β-strand | 205-213 | 9 | 1 |
| β-strand | 218-224 | 7 | 1 |
| β-strand | 227-235 | 9 | 1 |
| α-helix | 236-238 | 3 | |
| α-helix | 239-249 | 11 | |
| β-strand | 259 | 1 | 2 |
| β-strand | 262-269 | 8 | 1 |
| β-strand | 274-281 | 8 | 1 |
| β-strand | 287 | 1 | 2 |
| α-helix | 288-294 | 7 | |
| β-strand | 297 | 1 | 3 |
| α-helix | 299-317 | 19 | |
| β-strand | 320 | 1 | 4 |
| β-strand | 326 | 1 | 4 |
| β-strand | 329-330 | 2 | 5 |
| α-helix | 336-338 | 3 | |
| β-strand | 339-341 | 3 | 2 |
| β-strand | 347-349 | 3 | 2 |
| α-helix | 352-354 | 3 | |
| β-strand | 356-357 | 2 | 5 |
| β-strand | 358-359 | 2 | 6 |
| β-strand | 364-365 | 2 | 6 |
| α-helix | 376-378 | 3 | |
| α-helix | 381-384 | 4 | |
| α-helix | 393-413 | 21 | |
| β-strand | 415 | 1 | 3 |
| β-strand | 417 | 1 | 7 |
| β-strand | 420 | 1 | 7 |
| α-helix | 422-424 | 3 | |
| α-helix | 438-442 | 5 | |
| α-helix | 443-447 | 5 | |
| α-helix | 456-459 | 4 | |
| α-helix | 462-474 | 13 | |
| α-helix | 479-481 | 3 | |
| α-helix | 483-484 | 2 | |
| α-helix | 485-499 | 15 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| TGF-beta receptor type-1 | A | protein | 305 | Homo sapiens | P36897 (AlphaFold model) |
>4X2N_1 TGF-beta receptor type-1 (chains A) GTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHEN ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHM EIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRY MAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSV EEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQ EGIKM
Selection of fragments for kinase inhibitor design: decoration is key. Czodrowski, P., Holzemann, G., Barnickel, G. et al. J Med Chem (2015) 58:457-465. DOI 10.1021/jm501597j · PubMed
Other PDB entries of the same protein (UniProt P36897 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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