Structure of yeast importin a bound to the membrane protein Nuclear Localization Signal sequence of INM protein Heh1. Determined by X-ray diffraction at 2.25 Å resolution. Released 17 Jun 2015.
Explore 4XZR in 3D Show helices and sheets RCSB PDB PDBe
4XZR contains 31 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 101-115 | 15 | |
| α-helix | 123-127 | 5 | |
| α-helix | 132-137 | 6 | |
| α-helix | 145-159 | 15 | |
| α-helix | 163-171 | 9 | |
| α-helix | 175-184 | 10 | |
| α-helix | 187-201 | 15 | |
| α-helix | 205-213 | 9 | |
| α-helix | 217-223 | 7 | |
| α-helix | 229-243 | 15 | |
| α-helix | 249-250 | 2 | |
| α-helix | 252-255 | 4 | |
| α-helix | 256-258 | 3 | |
| α-helix | 259-265 | 7 | |
| α-helix | 271-284 | 14 | |
| α-helix | 289-297 | 9 | |
| α-helix | 300-307 | 8 | |
| α-helix | 313-326 | 14 | |
| α-helix | 331-339 | 9 | |
| α-helix | 342-349 | 8 | |
| α-helix | 355-368 | 14 | |
| α-helix | 373-381 | 9 | |
| α-helix | 385-394 | 10 | |
| α-helix | 397-412 | 16 | |
| α-helix | 413-415 | 3 | |
| α-helix | 418-426 | 9 | |
| α-helix | 430-436 | 7 | |
| α-helix | 442-465 | 24 | |
| α-helix | 472-479 | 8 | |
| α-helix | 483-486 | 4 | |
| α-helix | 498-508 | 11 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Inner nuclear membrane protein SRC1 | A | protein | 54 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q03707 (AlphaFold model) |
| Importin subunit alpha | B | protein | 423 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q02821 (AlphaFold model) |
>4XZR_1 Inner nuclear membrane protein SRC1 (chains A) SDTRKKRKDPDSDDWSESNSKENKIDNKHLNLLSSDSEIEQDYQKAKKRKTSDL
>4XZR_2 Importin subunit alpha (chains B) AELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEM LQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTD YRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLI YSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNI VTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIP PLVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIE VTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIE TYF
Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2. Lokareddy, R.K., Hapsari, R.A., van Rheenen, M. et al. Structure (2015) 23:1305-1316. DOI 10.1016/j.str.2015.04.017 · PubMed
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