4YKE: Mre11

Crystal structure of eukaryotic Mre11 catalytic domain from Chaetomium thermophilum. Determined by X-ray diffraction at 2.78 Å resolution. Released 3 Jun 2015.

Method
X-ray diffraction
Resolution
2.78 Å
Organism
Chaetomium thermophilum
Chains
2
Atoms
6,612
Mol. weight
126.19 kDa
Ligands
MN
Released
3 Jun 2015

Explore 4YKE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4YKE contains 33 α-helices and 50 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 18 helices, 25 β-strands

ElementResiduesLengthSheet
β-strand9-1571
β-strand2012
α-helix32-4615
β-strand51-5441
β-strand5912
α-helix66-8015
β-strand8113
α-helix85-862
β-strand89-9024
α-helix94-974
α-helix106-1083
β-strand11215
β-strand11413
β-strand118-12031
α-helix136-1427
β-strand147-14821
β-strand158-16036
α-helix161-1622
β-strand163-16754
β-strand170-17674
α-helix182-1909
β-strand194-19636
α-helix2061
β-strand207-21264
α-helix227-2293
β-strand236-23944
β-strand246-25164
α-helix2521
β-strand258-26144
α-helix272-2754
α-helix277-2782
β-strand279-28681
β-strand289-29681
α-helix301-3022
β-strand303-30977
α-helix318-3225
α-helix329-35325
α-helix363-3664
β-strand367-37377
α-helix387-3926
β-strand39518
β-strand39818
β-strand405-40847
Chain B: 15 helices, 25 β-strands
ElementResiduesLengthSheet
β-strand9-1579
β-strand20110
α-helix32-4615
β-strand51-5449
β-strand59110
α-helix66-8015
β-strand81111
α-helix85-862
β-strand89-90212
α-helix106-1083
β-strand11215
β-strand114111
β-strand118-12039
α-helix136-1427
β-strand147-14829
β-strand158-160313
β-strand163-167512
β-strand170-177812
α-helix182-1909
β-strand194-196313
α-helix2061
β-strand207-212612
α-helix227-2293
β-strand236-239412
β-strand246-251612
α-helix2521
β-strand258-261412
α-helix272-2754
α-helix277-2782
β-strand279-28689
β-strand289-29689
α-helix301-3022
β-strand303-309714
α-helix317-3226
α-helix326-35126
β-strand367-373714
α-helix387-3926
β-strand395115
β-strand398115
β-strand405-408414

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Mre11A, Bprotein548Chaetomium thermophilumG0RYR3 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4YKE_1 Mre11 (chains A, B)
MPQTAGPDTIRILVSTDNHVGYEERDPIRKDDSWRTFDEIMQLARTKDVDMVLLGGDLFH
DNKPSRKAMYQVMRSLRKNCLGMKPCELEFLSDPAEVFEGAFPHVNYYDPDINVSIPVFS
IHGNHDDPSGDGHLCSLDLLQVAGLVNYFGRVPEADNIHVKPILLQKGKTKLALYGMSNV
RDERIHRTFRDNKVRFYRPSQQTGDWFNLLTLHQNHYAHTPTGYLSENMLPDFLDLVIWG
HEHECLIDPKKNPETGFHVMQPGSSIATSLVPGEAVPKHIAILSITGKSFEVEKIPLRTV
RPFVIREITLATDKRFKGLEKKQDNRQEVTKRLMQIVEEMIAEANEMWRSLHEDSQDDED
EEQPLPLIRLKVEYSSPEGTKFEVENPQRFSNRFAGKVANQNDVVHFYRKKTGTTRKPKE
GKRELPEGIAEALEDSDSISVDALVQEFFAQQSLKILPQAPFGDAVNQFVSKDDKHAVEM
FVMDSLSSQVRGLLQLDDDKINEGLDSHIEDFRKVMEKNFLSGQQKQAQRRRRFKEKAAA
LEHHHHHH

Ligands and cofactors

IDNameFormulaCopies
MNManganese (II) ionMn4

Primary citation

Structure of the catalytic domain of Mre11 from Chaetomium thermophilum. Seifert, F.U., Lammens, K., Hopfner, K.P. Acta Crystallogr F Struct Biol Commun (2015) 71:752-757. DOI 10.1107/S2053230X15007566 · PubMed

Other PDB entries of the same protein (UniProt G0RYR3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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