Crystal structure of APP E2 domain in complex with DR6 CRD domain. Determined by X-ray diffraction at 2.2 Å resolution. Released 15 Apr 2015.
Explore 4YN0 in 3D Show helices and sheets RCSB PDB PDBe
4YN0 contains 15 α-helices and 22 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 53-57 | 5 | 1 |
| β-strand | 64-68 | 5 | 1 |
| α-helix | 69 | 1 | |
| β-strand | 70 | 1 | 2 |
| α-helix | 71 | 1 | |
| β-strand | 74-78 | 5 | 3 |
| β-strand | 87-90 | 4 | 3 |
| α-helix | 91-92 | 2 | |
| β-strand | 95-96 | 2 | 4 |
| β-strand | 101 | 1 | 2 |
| α-helix | 106 | 1 | |
| β-strand | 107-108 | 2 | 4 |
| α-helix | 109-114 | 6 | |
| β-strand | 118-121 | 4 | 5 |
| β-strand | 124 | 1 | 6 |
| β-strand | 127 | 1 | 6 |
| β-strand | 130-132 | 3 | 5 |
| α-helix | 133-134 | 2 | |
| β-strand | 137-140 | 4 | 7 |
| β-strand | 143-146 | 4 | 7 |
| α-helix | 147-149 | 3 | |
| β-strand | 150 | 1 | 8 |
| β-strand | 154-158 | 5 | 9 |
| β-strand | 167-170 | 4 | 9 |
| α-helix | 171-172 | 2 | |
| β-strand | 175-176 | 2 | 10 |
| β-strand | 181 | 1 | 8 |
| β-strand | 187-188 | 2 | 10 |
| α-helix | 189-190 | 2 | |
| α-helix | 193-195 | 3 | |
| β-strand | 198-201 | 4 | 11 |
| β-strand | 210-212 | 3 | 11 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 307-344 | 38 | |
| α-helix | 350-406 | 57 | |
| α-helix | 412-443 | 32 | |
| α-helix | 445-475 | 31 | |
| α-helix | 477-506 | 30 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Tumor necrosis factor receptor superfamily member 21 | A | protein | 190 | Mus musculus | Q9EPU5 (AlphaFold model) |
| Amyloid beta A4 protein | B | protein | 233 | Mus musculus | P12023 (AlphaFold model) |
>4YN0_1 Tumor necrosis factor receptor superfamily member 21 (chains A) GSQPEQKTLSLPGTYRHVDRTTGQVLTCDKCPAGTYVSEHCTNMSLRVCSSCPAGTFTRH ENGIERCHDCSQPCPWPMIERLPCAALTDRECICPPGMYQSNGTCAPHTVCPVGWGVRKK GTENEDVRCKQCARGTFSDVPSSVMKCKAHTDCLGQNLEVVKPGTKETDNVCGMRLFFSS TASGRGLVPR
>4YN0_2 Amyloid beta A4 protein (chains B) GSSTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKAD KKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRP HHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSL LYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDASGRGLVPR
The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation. Xu, K., Olsen, O., Tzvetkova-Robev, D. et al. Genes Dev (2015) 29:785-790. DOI 10.1101/gad.257675.114 · PubMed
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