4ZKC: The chemokine binding protein of orf virus

The chemokine binding protein of orf virus complexed with CCL7. Determined by X-ray diffraction at 3.15 Å resolution. Released 8 Jul 2015.

Method: X-ray diffraction
Resolution: 3.15 Å
Organisms: Orf virus (strain NZ2), Homo sapiens
Chains: 2
Atoms: 1,878
Mol. weight: 41.19 kDa
Released: 8 Jul 2015

Explore 4ZKC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4ZKC contains 5 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 14 β-strands

Element	Residues	Length	Sheet
α-helix	13-20	8
β-strand	27-37	11	1
β-strand	49-56	8	2
β-strand	59	1	3
β-strand	66	1	3
β-strand	67-76	10	2
β-strand	79-88	10	2
β-strand	94-101	8	1
β-strand	108-116	9	1
α-helix	129-140	12
β-strand	143-149	7	2
β-strand	202	1	1
β-strand	205-209	5	2
β-strand	214-225	12	1
α-helix	228-230	3
β-strand	237-242	6	1
α-helix	245-252	8
β-strand	260-265	6	1

Chain B: 1 helix, 4 β-strands

Element	Residues	Length	Sheet
β-strand	11-12	2	2
β-strand	25-30	6	4
β-strand	41-45	5	4
β-strand	51-53	3	4
α-helix	58-67	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Chemokine binding protein	A	protein	276	Orf virus (strain NZ2)	Q2F862
C-C motif chemokine 7	B	protein	82	Homo sapiens	P80098 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>4ZKC_1 Chemokine binding protein (chains A)
APLLESQRSNSEEKANFCSTHNDEVYARFRLQMRVGVRHSPLYTPSNMCMLDIEDSVEDI
EESTEKEYASTATGEAAGVNVSVALVGEGVSIPFSYIGLGFNPSLEDSYLYVNVSSRAPW
VKQTSDLSANGGWGIKQVLEKELLAIQIGCDNQKFPEEPTTTPPSPVTTTLSSTTPDLNE
ENTENTPTTTGASVDRKRNPADIDFSLLVDPRCVTSVDLHVELRDACIDYKQESPLSLKG
KYGDGELVKKEIKDVGKNHNMCSLNLNPGNENLYFQ

Sequence of entity 2 (B), FASTA

>4ZKC_2 C-C motif chemokine 7 (chains B)
QPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWV
QDFMKHLDKKTQTPKLHHHHHH

Primary citation

Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity. Counago, R.M., Knapp, K.M., Nakatani, Y. et al. Structure (2015) 23:1199-1213. DOI 10.1016/j.str.2015.04.023 · PubMed

Other PDB entries of the same protein (UniProt Q2F862), best resolution first:

4P5I 2.25 Å, Crystal structure of the chemokine binding protein from orf virus
4ZK9 2.6 Å, The chemokine binding protein of orf virus complexed with CCL2
4ZKB 2.9 Å, The chemokine binding protein of orf virus complexed with CCL3

Browse structure collections

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