Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid. Determined by X-ray diffraction at 1.23 Å resolution. Released 27 Apr 2016.
Explore 4ZX2 in 3D Show helices and sheets RCSB PDB PDBe
4ZX2 contains 14 α-helices and 18 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 168-170 | 3 | |
| β-strand | 182 | 1 | 1 |
| β-strand | 185 | 1 | 1 |
| α-helix | 188-199 | 12 | |
| α-helix | 206-221 | 16 | |
| β-strand | 226-229 | 4 | 2 |
| β-strand | 236-240 | 5 | 3 |
| β-strand | 242 | 1 | 4 |
| α-helix | 247-257 | 11 | |
| β-strand | 266-269 | 4 | 3 |
| α-helix | 279-292 | 14 | |
| β-strand | 297-300 | 4 | 3 |
| α-helix | 307-313 | 7 | |
| α-helix | 315-322 | 8 | |
| α-helix | 325-335 | 11 | |
| β-strand | 341-344 | 4 | 2 |
| β-strand | 348-350 | 3 | 2 |
| α-helix | 363-367 | 5 | |
| α-helix | 374-376 | 3 | |
| α-helix | 380-386 | 7 | |
| β-strand | 388-389 | 2 | 5 |
| β-strand | 395-397 | 3 | 5 |
| β-strand | 404-406 | 3 | 5 |
| α-helix | 408-417 | 10 | |
| β-strand | 422-425 | 4 | 2 |
| β-strand | 434-437 | 4 | 2 |
| α-helix | 438-440 | 3 | |
| β-strand | 442-445 | 4 | 2 |
| β-strand | 446 | 1 | 4 |
| α-helix | 451-453 | 3 | |
| β-strand | 459-465 | 7 | 3 |
| β-strand | 468-476 | 9 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Serine/threonine-protein phosphatase 5 | A | protein | 333 | Homo sapiens | P53041 (AlphaFold model) |
>4ZX2_1 Serine/threonine-protein phosphatase 5 (chains A) GASMTIEDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTL VETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTL FGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCING KVLIMHGGLFSEDGVTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQF GPDVTKAFLEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQG SDLRPQFHQFTAVPHPNVKPMAYANTLLQLGMM
| ID | Name | Formula | Copies |
|---|---|---|---|
| MRD | (4R)-2-methylpentane-2,4-diol | C6 H14 O2 | 1 |
| 4TE | (1S,2R,3S,4R,5S)-5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid | C9 H12 O5 | 1 |
| MN | Manganese (II) ion | Mn | 2 |
Water and common crystallization additives (MPD) are not listed.
Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Chattopadhyay, D., Swingle, M.R., Salter, E.A. et al. Biochem Pharmacol (2016) 109:14-26. DOI 10.1016/j.bcp.2016.03.011 · PubMed
Other PDB entries of the same protein (UniProt P53041 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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