5DSE: TTC7B/Hyccin Complex

Crystal Structure of the TTC7B/Hyccin Complex. Determined by X-ray diffraction at 2.9 Å resolution. Released 2 Dec 2015.

Method
X-ray diffraction
Resolution
2.9 Å
Organism
Homo sapiens
Chains
4
Atoms
13,875
Mol. weight
257.16 kDa
Released
2 Dec 2015

Explore 5DSE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5DSE contains 104 α-helices and 8 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 30 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix141-15212
α-helix172-19221
α-helix216-23217
α-helix235-24713
α-helix249-2502
α-helix255-27218
α-helix324-33916
α-helix364-37411
α-helix379-38911
α-helix397-41014
α-helix413-42614
α-helix432-44211
α-helix448-45811
α-helix466-48621
α-helix490-51021
α-helix515-52713
α-helix531-54414
α-helix549-56113
α-helix565-57814
α-helix583-59614
α-helix599-61618
α-helix692-70918
α-helix712-72514
α-helix730-74314
α-helix746-75914
α-helix764-77714
α-helix780-79314
α-helix798-81114
α-helix814-82916
α-helix836-8383
Chain B: 15 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix8-147
α-helix37-4610
α-helix54-6512
α-helix69-768
α-helix79-9113
α-helix100-11213
β-strand123-12641
α-helix127-1282
β-strand159-16351
α-helix165-1684
α-helix176-19015
α-helix197-21216
α-helix217-2215
α-helix229-2313
α-helix234-24815
α-helix253-26917
α-helix273-28513
Chain C: 41 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix9-1911
α-helix26-327
α-helix43-5917
α-helix66-683
α-helix73-8816
α-helix93-11018
α-helix113-12311
α-helix125-1273
α-helix135-15420
α-helix168-19528
α-helix216-23116
α-helix235-24713
β-strand24812
α-helix249-2502
α-helix255-27117
α-helix275-2773
α-helix284-2863
β-strand31212
β-strand31913
α-helix324-33916
α-helix360-37415
α-helix379-38911
α-helix390-3923
α-helix397-40913
α-helix413-42614
α-helix432-44110
α-helix448-46013
α-helix468-48619
α-helix490-51021
α-helix515-52713
α-helix531-54414
α-helix549-56113
α-helix565-57814
α-helix583-59614
α-helix599-61618
α-helix690-70920
α-helix712-72312
α-helix730-74314
α-helix746-75914
α-helix764-77613
α-helix780-79314
α-helix798-81114
α-helix814-82815
α-helix836-8383
Chain D: 18 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix8-169
α-helix25-284
α-helix35-4612
α-helix53-6513
α-helix69-768
α-helix79-9012
α-helix100-11415
α-helix120-1212
β-strand123-12644
α-helix127-1282
β-strand13413
α-helix144-1474
β-strand159-16354
α-helix165-1684
α-helix177-19014
α-helix192-1943
α-helix197-21216
α-helix217-2215
α-helix234-24815
α-helix253-27018
α-helix273-28513

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Tetratricopeptide repeat protein 7BA, Cprotein837Homo sapiensQ86TV6 (AlphaFold model)
HyccinB, Dprotein312Homo sapiensQ9BYI3 (AlphaFold model)
Sequence of entity 1 (A, C), FASTA
>5DSE_1 Tetratricopeptide repeat protein 7B (chains A, C)
GSRLETEIERCRSECQWERIPELVKQLSAKLIANDDMAELLLGESKLEQYLKEHPLRQGA
SPRGPKPQLTEVRKHLTAALDRGNLKSEFLQESNLIMAKLNYVEGDYKEALNIYARVGLD
DLPLTAVPPYRLRVIAEAYATKGLCLEKLPISSSTSNLHVDREQDVITCYEKAGDIALLY
LQEIERVILSNIQNRSPKPGPAPHDQELGFFLETGLQRAHVLYFKNGNLTRGVGRFRELL
RAVETRTTQNLRMTIARQLAEILLRGMCEQSYWNPLEDPPCQSPLDDPLRKGANTKTYTL
TRRARVYSGENIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLISLQSASVVY
DLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRL
KPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATD
ASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGYVRQALQLQG
DDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTC
KHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHATSVAAS
RVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLF
PMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKI
LRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSPAVPFTIIPRVL
Sequence of entity 2 (B, D), FASTA
>5DSE_2 Hyccin (chains B, D)
GPLGSFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSELLEPV
CHQLFEFYRSGEEQLLQFTLQFLPELIWCYLAVSASRNVHSSGCIEALLLGVYNLEIVDK
QGHTKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQN
RFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYKGISSRIPVSSGF
MVQMLTGIYFAFYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGPMKSNKE
GTRCIQVEITPT

Primary citation

The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Baskin, J.M., Wu, X., Christiano, R. et al. Nat Cell Biol (2016) 18:132-138. DOI 10.1038/ncb3271 · PubMed

Other PDB entries of the same protein (UniProt Q86TV6 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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