5F3Y: Myo7b N-MyTH4-FERM-SH3

Crystal Structure of Myo7b N-MyTH4-FERM-SH3 in complex with Anks4b CEN. Determined by X-ray diffraction at 3.41 Å resolution. Released 16 Mar 2016.

Method
X-ray diffraction
Resolution
3.41 Å
Organism
Mus musculus
Chains
2
Atoms
4,041
Mol. weight
81.6 kDa
Released
16 Mar 2016

Explore 5F3Y in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5F3Y contains 24 α-helices and 25 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 24 helices, 23 β-strands

ElementResiduesLengthSheet
α-helix973-9808
α-helix1006-102116
α-helix1068-108114
α-helix1085-109713
α-helix1103-111917
α-helix1121-11233
α-helix1127-11359
α-helix1142-115514
α-helix1161-11633
α-helix1164-11729
β-strand1176-118271
β-strand1187-119261
β-strand119712
α-helix1198-120912
β-strand1217-122371
β-strand1226-122941
β-strand123612
α-helix1237-125115
β-strand1260-126671
α-helix1279-129517
α-helix1303-131715
α-helix1324-133411
α-helix1337-13404
α-helix1345-135915
α-helix1368-138215
β-strand1389-139353
β-strand1394-139744
β-strand1406-141053
β-strand1415-141843
β-strand1424-142853
α-helix1430-14323
β-strand1433-143864
β-strand1447-145264
β-strand1456-146054
α-helix1464-148118
β-strand1484-148745
β-strand149116
β-strand149915
α-helix1500-15012
β-strand150216
β-strand1507-150935
β-strand1522-152765
β-strand1533-153755
α-helix1538-15403
β-strand1541-154335
α-helix1549-15513
α-helix1552-15576
Chain B: 0 helices, 2 β-strands
ElementResiduesLengthSheet
β-strand266-26721
β-strand271-27221

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Unconventional myosin-VIIbAprotein621Mus musculusQ99MZ6 (AlphaFold model)
Ankyrin repeat and SAM domain-containing protein 4BBprotein102Mus musculusQ8K3X6 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>5F3Y_1 Unconventional myosin-VIIb (chains A)
GSEFEEEVDSLAEYTFPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALDVWIII
LRFMGDLPEPVVYGRNSLTGSSVMRQIHDKLGKDSVTQHNRSSQVASQLNFGEEAFKFDG
PISDRPMSNLEKVHFIVGYAIMRPGLRDEIYCQICKQLSENYKTSSRARGWILLSLCLGC
FPPSERFMKYLLNFISQGPPSYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQ
VILATGRSLTISVDSASTSREICQHVAQKQGLRDNLGFSLQVAVYDKFWSLGSGCDHLMD
AVAQCEQLARERGESQRQAPWRIYFRKEFFTPWHDSQEDPVSTELIYHQVLRGVWSGEYN
FEKEEELVELLARHCYVQLGATVKSNAVQELLPSCVPSKLYRTKSPEKWASLVTAAHAKA
QYTQSKATPLAVREQTVEAARLLWPLLFSRLFEVTTLSGPRLPKTQLVLAINWKGMYFLD
QKERTLLGLSFAEVMGLVANRDAPGGKKLLLATLQEEYEFVSPSSVAIAEMVALFLGGLK
ERSVFAMALQDRRATDDITLLPFKKGDLLILTKKQGLLASENWALGQNDRTGKTGLVPTA
CLYTIPSVTKPSTQLLSLLAM
Sequence of entity 2 (B), FASTA
>5F3Y_2 Ankyrin repeat and SAM domain-containing protein 4B (chains B)
GSVEEDDDVQHESILNRPGLGSIVFSRNRVLDFEDISDSKRELGFKMPSELFQRQGAAGT
VEEEEEEEEEEEEEKREANGTAGDLPWDEEEVEWEEDAVDAT

Primary citation

Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex. Li, J., He, Y., Lu, Q. et al. Dev Cell (2016) 36:179-189. DOI 10.1016/j.devcel.2015.12.020 · PubMed

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