PI4KB in complex with Rab11 and the MI356 Inhibitor. Determined by X-ray diffraction at 3.37 Å resolution. Released 28 Dec 2016.
Explore 5FBL in 3D Show helices and sheets RCSB PDB PDBe
5FBL contains 34 α-helices and 17 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 129-134 | 6 | |
| α-helix | 141-150 | 10 | |
| α-helix | 154-163 | 10 | |
| α-helix | 164-166 | 3 | |
| α-helix | 169-173 | 5 | |
| α-helix | 176-185 | 10 | |
| α-helix | 188-204 | 17 | |
| α-helix | 206-218 | 13 | |
| α-helix | 233-241 | 9 | |
| α-helix | 308-323 | 16 | |
| α-helix | 324-326 | 3 | |
| α-helix | 330-346 | 17 | |
| β-strand | 361-365 | 5 | 1 |
| α-helix | 368-370 | 3 | |
| β-strand | 372-373 | 2 | 1 |
| β-strand | 382-390 | 9 | 1 |
| α-helix | 394-396 | 3 | |
| α-helix | 398-402 | 5 | |
| α-helix | 537-547 | 11 | |
| β-strand | 556-564 | 9 | 1 |
| α-helix | 570-588 | 19 | |
| β-strand | 600-602 | 3 | 1 |
| β-strand | 608-610 | 3 | 1 |
| α-helix | 612-613 | 2 | |
| β-strand | 616-618 | 3 | 2 |
| α-helix | 619-626 | 8 | |
| α-helix | 630-638 | 9 | |
| α-helix | 644-666 | 23 | |
| β-strand | 677-680 | 4 | 2 |
| β-strand | 685-687 | 3 | 2 |
| α-helix | 712-717 | 6 | |
| α-helix | 724-741 | 18 | |
| α-helix | 744-754 | 11 | |
| α-helix | 761-763 | 3 | |
| α-helix | 768-774 | 7 | |
| α-helix | 782-798 | 17 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 10-17 | 8 | 3 |
| α-helix | 24-33 | 10 | |
| α-helix | 41-43 | 3 | |
| β-strand | 47-55 | 9 | 3 |
| β-strand | 58-66 | 9 | 3 |
| β-strand | 86-92 | 7 | 3 |
| α-helix | 96-100 | 5 | |
| α-helix | 102-112 | 11 | |
| β-strand | 118-124 | 7 | 3 |
| α-helix | 129-131 | 3 | |
| α-helix | 136-145 | 10 | |
| β-strand | 149-152 | 4 | 3 |
| β-strand | 154 | 1 | 4 |
| β-strand | 159 | 1 | 4 |
| α-helix | 161-173 | 13 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta | A | protein | 572 | Homo sapiens | Q9UBF8 (AlphaFold model) |
| Ras-related protein Rab-11A | B | protein | 221 | Homo sapiens | P62491 (AlphaFold model) |
>5FBL_1 Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta (chains A) SWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMD EDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKP AHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSS STESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARV WLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRRDPED PSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWE QERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFL SAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSA FKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSS TIRNLKERFHMSMTEEQLQLLVEQMVDGSMRS
>5FBL_2 Ras-related protein Rab-11A (chains B) GAMGSMGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQV DGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADS NIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRI VSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
| ID | Name | Formula | Copies |
|---|---|---|---|
| GSP | 5'-guanosine-diphosphate-monothiophosphate | C10 H16 N5 O13 P3 S | 1 |
| 5W9 | ~{N}-[2-[[6-chloranyl-3-(4-methoxy-3-morpholin-4-ylsulfonyl-phenyl)-2-methyl-im… | C22 H27 Cl N6 O5 S | 1 |
PI4KB in complex with Rab11 and the MI356 Inhibitor. Chalupska, D., Mejdrova, I., Nencka, R. et al. To be published.
Other PDB entries of the same protein (UniProt Q9UBF8 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 5FBL directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.