PI4KB in complex with Rab11 and the MI358 Inhibitor. Determined by X-ray diffraction at 3.79 Å resolution. Released 28 Dec 2016.
Explore 5FBQ in 3D Show helices and sheets RCSB PDB PDBe
5FBQ contains 36 α-helices and 15 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 129-134 | 6 | |
| α-helix | 141-150 | 10 | |
| α-helix | 154-163 | 10 | |
| α-helix | 164-166 | 3 | |
| α-helix | 169-173 | 5 | |
| α-helix | 176-185 | 10 | |
| α-helix | 188-204 | 17 | |
| α-helix | 206-218 | 13 | |
| α-helix | 233-241 | 9 | |
| α-helix | 308-323 | 16 | |
| α-helix | 324-326 | 3 | |
| α-helix | 330-346 | 17 | |
| β-strand | 361-365 | 5 | 1 |
| α-helix | 368-370 | 3 | |
| β-strand | 372-373 | 2 | 1 |
| β-strand | 382-390 | 9 | 1 |
| α-helix | 394-396 | 3 | |
| α-helix | 398-402 | 5 | |
| α-helix | 537-547 | 11 | |
| α-helix | 549-552 | 4 | |
| β-strand | 556-564 | 9 | 1 |
| α-helix | 570-588 | 19 | |
| β-strand | 600-602 | 3 | 1 |
| β-strand | 608-610 | 3 | 1 |
| α-helix | 612-613 | 2 | |
| β-strand | 616-618 | 3 | 2 |
| α-helix | 619-626 | 8 | |
| α-helix | 630-638 | 9 | |
| α-helix | 644-666 | 23 | |
| β-strand | 677-680 | 4 | 2 |
| β-strand | 685-687 | 3 | 2 |
| α-helix | 712-717 | 6 | |
| α-helix | 724-741 | 18 | |
| α-helix | 744-754 | 11 | |
| α-helix | 761-763 | 3 | |
| α-helix | 768-774 | 7 | |
| α-helix | 782-797 | 16 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 10-17 | 8 | 3 |
| α-helix | 24-33 | 10 | |
| α-helix | 41-43 | 3 | |
| β-strand | 47-55 | 9 | 3 |
| β-strand | 58-66 | 9 | 3 |
| α-helix | 78-81 | 4 | |
| β-strand | 86-92 | 7 | 3 |
| α-helix | 96-100 | 5 | |
| α-helix | 102-112 | 11 | |
| β-strand | 118-124 | 7 | 3 |
| α-helix | 129-131 | 3 | |
| α-helix | 136-145 | 10 | |
| β-strand | 149-153 | 5 | 3 |
| α-helix | 161-173 | 13 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta | A | protein | 572 | Homo sapiens | Q9UBF8 (AlphaFold model) |
| Ras-related protein Rab-11A | B | protein | 221 | Homo sapiens | P62491 (AlphaFold model) |
>5FBQ_1 Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta (chains A) SWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMD EDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKP AHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSS STESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARV WLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRRDPED PSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWE QERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFL SAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSA FKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSS TIRNLKERFHMSMTEEQLQLLVEQMVDGSMRS
>5FBQ_2 Ras-related protein Rab-11A (chains B) GAMGSMGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQV DGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADS NIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRI VSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
| ID | Name | Formula | Copies |
|---|---|---|---|
| GDP | Guanosine-5'-diphosphate | C10 H15 N5 O11 P2 | 1 |
| 5W6 | ~{N}-[2-[[6-chloranyl-3-[3-[4-(hydroxymethyl)piperidin-1-yl]sulfonyl-4-methoxy-… | C24 H31 Cl N6 O5 S | 1 |
PI4KB in complex with Rab11 and the MI358 Inhibitor. Chalupska, D., Mejdrova, I., Nencka, R. et al. To be published.
Other PDB entries of the same protein (UniProt Q9UBF8 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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