5GJR: An atomic structure of the human 26S proteasome
An atomic structure of the human 26S proteasome. Determined by electron microscopy at 3.5 Å resolution. Released 7 Sept 2016.
- Method
- Electron microscopy
- Resolution
- 3.5 Å
- Organism
- Homo sapiens
- Chains
- 64
- Atoms
- 142,753
- Mol. weight
- 2567.66 kDa
- Ligands
- ADP
- Released
- 7 Sept 2016
Explore 5GJR in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
5GJR contains 940 α-helices and 665 β-strands across 64 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chains 0 and M: 14 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 45-83 | 39 | |
| β-strand | 88 | 1 | 165 |
| β-strand | 89 | 1 | 134 |
| β-strand | 91-93 | 3 | 158 |
| β-strand | 122-126 | 5 | 158 |
| β-strand | 131-134 | 4 | 158 |
| β-strand | 151-153 | 3 | 166 |
| β-strand | 154 | 1 | 165 |
| β-strand | 160-163 | 4 | 166 |
| α-helix | 164 | 1 | |
| α-helix | 170-173 | 4 | |
| α-helix | 192-207 | 16 | |
| α-helix | 210-213 | 4 | |
| β-strand | 223-226 | 4 | 167 |
| α-helix | 234-243 | 10 | |
| β-strand | 247-252 | 6 | 167 |
| α-helix | 264-274 | 11 | |
| α-helix | 275-277 | 3 | |
| β-strand | 281-286 | 6 | 167 |
| α-helix | 288-290 | 3 | |
| α-helix | 305-317 | 13 | |
| β-strand | 326-332 | 7 | 167 |
| β-strand | 350-353 | 4 | 167 |
| α-helix | 360-371 | 12 | |
| α-helix | 381-387 | 7 | |
| α-helix | 393-409 | 17 | |
| α-helix | 417-427 | 11 | |
Chains 1 and N: 45 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-13 | 8 | |
| α-helix | 17-38 | 22 | |
| α-helix | 42-49 | 8 | |
| α-helix | 55-57 | 3 | |
| α-helix | 58-70 | 13 | |
| α-helix | 75-84 | 10 | |
| α-helix | 95-117 | 23 | |
| α-helix | 128-144 | 17 | |
| α-helix | 147-157 | 11 | |
| α-helix | 166-170 | 5 | |
| α-helix | 178-187 | 10 | |
| α-helix | 191-206 | 16 | |
| α-helix | 213-223 | 11 | |
| α-helix | 226-239 | 14 | |
| α-helix | 242-253 | 12 | |
| α-helix | 258-270 | 13 | |
| α-helix | 323-328 | 6 | |
| α-helix | 332-345 | 14 | |
| α-helix | 350-357 | 8 | |
| α-helix | 364-377 | 14 | |
| α-helix | 384-388 | 5 | |
| α-helix | 391-395 | 5 | |
| α-helix | 398-411 | 14 | |
| α-helix | 418-424 | 7 | |
| α-helix | 436-450 | 15 | |
| α-helix | 455-467 | 13 | |
| α-helix | 472-485 | 14 | |
| α-helix | 491-502 | 12 | |
| α-helix | 508-519 | 12 | |
| α-helix | 526-538 | 13 | |
| α-helix | 543-555 | 13 | |
| α-helix | 564-572 | 9 | |
| α-helix | 576-590 | 15 | |
| α-helix | 596-608 | 13 | |
| α-helix | 612-625 | 14 | |
| α-helix | 633-641 | 9 | |
| α-helix | 646-659 | 14 | |
| α-helix | 666-675 | 10 | |
| α-helix | 681-695 | 15 | |
| α-helix | 706-718 | 13 | |
| α-helix | 726-737 | 12 | |
| β-strand | 744-746 | 3 | 9 |
| α-helix | 757-767 | 11 | |
| α-helix | 776-780 | 5 | |
| β-strand | 783-785 | 3 | 9 |
| α-helix | 886-890 | 5 | |
| α-helix | 934-938 | 5 | |
Chains 2 and O: 24 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-13 | 10 | |
| α-helix | 20-31 | 12 | |
| α-helix | 34-46 | 13 | |
| α-helix | 48-50 | 3 | |
| α-helix | 58-59 | 2 | |
| α-helix | 60-64 | 5 | |
| α-helix | 65-66 | 2 | |
| α-helix | 67-69 | 3 | |
| α-helix | 73-86 | 14 | |
| α-helix | 90-102 | 13 | |
| α-helix | 109-125 | 17 | |
| α-helix | 128-144 | 17 | |
| α-helix | 150-166 | 17 | |
| α-helix | 169-181 | 13 | |
| α-helix | 190-206 | 17 | |
| α-helix | 214-217 | 4 | |
| α-helix | 222-225 | 4 | |
| α-helix | 231-241 | 11 | |
| α-helix | 245-255 | 11 | |
| α-helix | 260-262 | 3 | |
| α-helix | 265-283 | 19 | |
| β-strand | 290-292 | 3 | 18 |
| α-helix | 293-300 | 8 | |
| α-helix | 307-316 | 10 | |
| β-strand | 320-325 | 6 | 18 |
| β-strand | 330-336 | 7 | 18 |
| α-helix | 343-367 | 25 | |
Chains 3 and P: 27 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-23 | 18 | |
| α-helix | 45-52 | 8 | |
| α-helix | 57-76 | 20 | |
| α-helix | 83-92 | 10 | |
| α-helix | 100-108 | 9 | |
| α-helix | 118-131 | 14 | |
| α-helix | 140-147 | 8 | |
| α-helix | 148-152 | 5 | |
| α-helix | 153-154 | 2 | |
| α-helix | 159-166 | 8 | |
| α-helix | 171-173 | 3 | |
| α-helix | 179-196 | 18 | |
| α-helix | 200-207 | 8 | |
| α-helix | 211-215 | 5 | |
| α-helix | 217-237 | 21 | |
| α-helix | 241-251 | 11 | |
| α-helix | 254-258 | 5 | |
| α-helix | 260-276 | 17 | |
| α-helix | 278 | 1 | |
| α-helix | 281-292 | 12 | |
| α-helix | 295-297 | 3 | |
| α-helix | 301-310 | 10 | |
| α-helix | 317-330 | 14 | |
| α-helix | 349-366 | 18 | |
| β-strand | 370-374 | 5 | 18 |
| α-helix | 376-381 | 6 | |
| α-helix | 386-398 | 13 | |
| β-strand | 405-407 | 3 | 18 |
| β-strand | 412-414 | 3 | 18 |
| α-helix | 421-452 | 32 | |
Chains 4 and Q: 23 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-15 | 13 | |
| α-helix | 19-31 | 13 | |
| α-helix | 39-57 | 19 | |
| α-helix | 62-77 | 16 | |
| α-helix | 82-88 | 7 | |
| α-helix | 93-97 | 5 | |
| α-helix | 103-120 | 18 | |
| α-helix | 123-140 | 18 | |
| α-helix | 144-158 | 15 | |
| α-helix | 163-179 | 17 | |
| α-helix | 183-199 | 17 | |
| α-helix | 205-220 | 16 | |
| α-helix | 225-240 | 16 | |
| α-helix | 247-261 | 15 | |
| α-helix | 265-270 | 6 | |
| α-helix | 273-277 | 5 | |
| α-helix | 284-295 | 12 | |
| α-helix | 300-307 | 8 | |
| α-helix | 310-313 | 4 | |
| α-helix | 323-338 | 16 | |
| β-strand | 343 | 1 | 18 |
| β-strand | 345-346 | 2 | 35 |
| α-helix | 347-354 | 8 | |
| α-helix | 358-370 | 13 | |
| β-strand | 376-379 | 4 | 35 |
| β-strand | 384-387 | 4 | 35 |
| α-helix | 395-421 | 27 | |
Chains 5 and R: 22 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 18-27 | 10 | |
| α-helix | 36-46 | 11 | |
| α-helix | 52-61 | 10 | |
| α-helix | 67-92 | 26 | |
| α-helix | 97-113 | 17 | |
| α-helix | 117-131 | 15 | |
| α-helix | 135-139 | 5 | |
| α-helix | 140-151 | 12 | |
| α-helix | 155-170 | 16 | |
| α-helix | 176-190 | 15 | |
| α-helix | 195-202 | 8 | |
| α-helix | 216-230 | 15 | |
| α-helix | 233-236 | 4 | |
| α-helix | 237-241 | 5 | |
| α-helix | 244-250 | 7 | |
| α-helix | 256-264 | 9 | |
| α-helix | 268-282 | 15 | |
| α-helix | 292-308 | 17 | |
| β-strand | 311 | 1 | 35 |
| β-strand | 313-315 | 3 | 43 |
| α-helix | 316-323 | 8 | |
| α-helix | 327-338 | 12 | |
| β-strand | 345-348 | 4 | 43 |
| β-strand | 353-356 | 4 | 43 |
| α-helix | 357-360 | 4 | |
| α-helix | 361-388 | 28 | |
Chains 6 and S: 27 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 59-66 | 8 | |
| α-helix | 74-84 | 11 | |
| α-helix | 85-87 | 3 | |
| α-helix | 91-100 | 10 | |
| α-helix | 105-115 | 11 | |
| α-helix | 161-177 | 17 | |
| α-helix | 181-197 | 17 | |
| α-helix | 202-217 | 16 | |
| α-helix | 221-224 | 4 | |
| α-helix | 226-241 | 16 | |
| α-helix | 244-260 | 17 | |
| α-helix | 265-272 | 8 | |
| α-helix | 282-298 | 17 | |
| α-helix | 305-314 | 10 | |
| α-helix | 322-338 | 17 | |
| α-helix | 342-344 | 3 | |
| α-helix | 345-347 | 3 | |
| α-helix | 352-355 | 4 | |
| α-helix | 358-369 | 12 | |
| α-helix | 372-387 | 16 | |
| α-helix | 391-395 | 5 | |
| α-helix | 396-398 | 3 | |
| α-helix | 399-412 | 14 | |
| β-strand | 416-418 | 3 | 49 |
| α-helix | 419-425 | 7 | |
| α-helix | 431-443 | 13 | |
| β-strand | 449-452 | 4 | 49 |
| β-strand | 457-460 | 4 | 49 |
| α-helix | 470-493 | 24 | |
| α-helix | 510-524 | 15 | |
Chains 7 and T: 12 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 90-99 | 10 | |
| α-helix | 102-123 | 22 | |
| α-helix | 136-157 | 22 | |
| α-helix | 161-176 | 16 | |
| α-helix | 187-201 | 15 | |
| α-helix | 205-214 | 10 | |
| α-helix | 227-236 | 10 | |
| α-helix | 241-249 | 9 | |
| α-helix | 256-278 | 23 | |
| β-strand | 281-283 | 3 | 56 |
| α-helix | 284-291 | 8 | |
| α-helix | 297-305 | 9 | |
| β-strand | 310-311 | 2 | 56 |
| β-strand | 314-316 | 3 | 56 |
| α-helix | 333-347 | 15 | |
36 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 26S protease regulatory subunit 4 | I, w | protein | 440 | Homo sapiens | P62191 (AlphaFold model) |
| 26S protease regulatory subunit 7 | H, v | protein | 433 | Homo sapiens | P35998 (AlphaFold model) |
| 26S protease regulatory subunit 10B | L, z | protein | 389 | Homo sapiens | P62333 (AlphaFold model) |
| 26S protease regulatory subunit 6A | 0, M | protein | 439 | Homo sapiens | P17980 (AlphaFold model) |
| 26S protease regulatory subunit 8 | J, x | protein | 406 | Homo sapiens | P62195 |
| 26S protease regulatory subunit 6B | K, y | protein | 418 | Homo sapiens | P43686 |
| 26S proteasome non-ATPase regulatory subunit 1 | 1, N | protein | 953 | Homo sapiens | Q99460 |
| 26S proteasome non-ATPase regulatory subunit 13 | 2, O | protein | 376 | Homo sapiens | Q9UNM6 |
| 26S proteasome non-ATPase regulatory subunit 12 | 3, P | protein | 456 | Homo sapiens | O00232 |
| 26S proteasome non-ATPase regulatory subunit 11 | 4, Q | protein | 422 | Homo sapiens | O00231 |
| 26S proteasome non-ATPase regulatory subunit 6 | 5, R | protein | 389 | Homo sapiens | Q15008 |
| 26S proteasome non-ATPase regulatory subunit 3 | 6, S | protein | 525 | Homo sapiens | O43242 |
20 more molecules are not listed.
Sequence of entity 1 (I, w), FASTA
>5GJR_1 26S protease regulatory subunit 4 (chains I, w)
MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRL
KLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNH
AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAP
QETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVA
NQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSG
GEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKT
KKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFK
KSKENVLYKKQEGTPEGLYL
Sequence of entity 2 (H, v), FASTA
>5GJR_2 26S protease regulatory subunit 7 (chains H, v)
MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKIN
ELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAK
FVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGC
KEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRV
IGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTML
ELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHAR
SMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSY
AKFSATPRYMTYN
Sequence of entity 3 (L, z), FASTA
>5GJR_3 26S protease regulatory subunit 10B (chains L, z)
MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEV
LKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVY
NMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGK
TLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGG
RRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIH
IDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHD
FVVQEDFMKAVRKVADSKKLESKLDYKPV
Sequence of entity 4 (0, M), FASTA
>5GJR_4 26S protease regulatory subunit 6A (chains 0, M)
MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL
RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK
CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER
PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC
AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK
AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE
ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY
MEGILEVQAKKKANLQYYA
Sequence of entity 5 (J, x), FASTA
>5GJR_5 26S protease regulatory subunit 8 (chains J, x)
MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLR
EELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDS
YTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGI
AQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMARE
HAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDI
LDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVK
GVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
Sequence of entity 6 (K, y), FASTA
>5GJR_6 26S protease regulatory subunit 6B (chains K, y)
MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY
IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID
RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA
VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL
GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD
QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL
EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
Sequence of entity 7 (1, N), FASTA
>5GJR_7 26S proteasome non-ATPase regulatory subunit 1 (chains 1, N)
MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFA
ALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPE
GEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYS
LKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKED
NLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETE
EKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV
RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEAL
QLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLG
LGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQ
HEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIR
RLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICC
AGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDK
HDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLS
LAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAK
KKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRY
QPFKPLSIGGIIILKDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD
Sequence of entity 8 (2, O), FASTA
>5GJR_8 26S proteasome non-ATPase regulatory subunit 13 (chains 2, O)
MKDVPGFLQQSQNSGPGQPAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLY
ENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGA
LKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFL
GCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAF
NSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSA
KITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDV
KSMEMLVEHQAHDILT
Sequence of entity 9 (3, P), FASTA
>5GJR_9 26S proteasome non-ATPase regulatory subunit 12 (chains 3, P)
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM
VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI
KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK
ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY
LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP
KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE
HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD
PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ
Sequence of entity 10 (4, Q), FASTA
>5GJR_10 26S proteasome non-ATPase regulatory subunit 11 (chains 4, Q)
MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT
GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE
KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL
SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD
SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA
DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD
VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK
LT
Sequence of entity 11 (5, R), FASTA
>5GJR_11 26S proteasome non-ATPase regulatory subunit 6 (chains 5, R)
MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKS
LDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGA
LTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRL
KVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKV
IKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMR
IHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPD
SKNWQYQETIKKGDLLLNRVQKLSRVINM
Sequence of entity 12 (6, S), FASTA
>5GJR_12 26S proteasome non-ATPase regulatory subunit 3 (chains 6, S)
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAA
EHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGF
FTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR
YKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATL
RHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQL
EYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPY
FLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLA
DIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRI
SFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEM
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 12 |
Primary citation
An atomic structure of the human 26S proteasome. Huang, X., Luan, B., Wu, J. et al. Nat Struct Mol Biol (2016) 23:778-785. DOI 10.1038/nsmb.3273 · PubMed
Other PDB entries of the same protein (UniProt P62191 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9K53 2.5 Å, Structure of substrate-engaged human 26S proteasome RP-CP subcomplex in state ED2.1
- 8USD 2.7 Å, Rpn1/Nub1UBL-focused alignment of the non-substrate-engaged human 26S proteasome
- 8USB 2.73 Å, Non-substrate-engaged human 26S proteasome with Nub1/FAT10 bound to Rpn1
- 9MBP 2.75 Å, Substrate-engaged human 26S proteasome bound to midnolin with RPT1 at top of spiral…
- 9PDL 2.76 Å, Nub1/Fat10-processing human 26S proteasome with Rpt5 at top of spiral staircase (AAA+…
- 9NKG 2.8 Å, Structure of substrate engaged MIDN-bound human 26S proteasome, EB-MIDN (Composite map)
- 9E8I 2.87 Å, Human proteasome in resting state conformation bound to TXNL1 in Forward conformation
- 9BV3 2.9 Å, M1B Midnolin-Proteasome
- 9E8H 2.9 Å, Human proteasome in resting state conformation bound to TXNL1 in backward conformation
- 9K4J 2.9 Å, Structure of substrate-engaged human 26S proteasome RP-CP subcomplex in state EA1.0
- 9NKF 2.9 Å, Structure of human substrate-free 26S proteasome in the presence of ATPgS and…
- 9U3L 2.91 Å, Substrate-engaged human 26S proteasome bound to midnolin with RPT2 at top of spiral…
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