5MPE: 26S proteasome in presence of ATP
26S proteasome in presence of ATP (s2). Determined by electron microscopy at 4.5 Å resolution. Released 8 Mar 2017.
- Method
- Electron microscopy
- Resolution
- 4.5 Å
- Organism
- Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
- Chains
- 13
- Atoms
- 40,974
- Mol. weight
- 633.81 kDa
- Released
- 8 Mar 2017
Explore 5MPE in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
5MPE contains 273 α-helices and 74 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain N: 52 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-14 | 8 | |
| α-helix | 18-29 | 12 | |
| α-helix | 38-40 | 3 | |
| α-helix | 44-51 | 8 | |
| α-helix | 58-72 | 15 | |
| α-helix | 75-85 | 11 | |
| α-helix | 90-93 | 4 | |
| α-helix | 100-117 | 18 | |
| α-helix | 131-147 | 17 | |
| α-helix | 151-160 | 10 | |
| α-helix | 164-172 | 9 | |
| α-helix | 179-196 | 18 | |
| α-helix | 200-216 | 17 | |
| α-helix | 223-232 | 10 | |
| α-helix | 235-245 | 11 | |
| α-helix | 251-264 | 14 | |
| α-helix | 267-280 | 14 | |
| α-helix | 284-291 | 8 | |
| α-helix | 293-306 | 14 | |
| α-helix | 312-320 | 9 | |
| α-helix | 326-339 | 14 | |
| α-helix | 347-351 | 5 | |
| α-helix | 353-357 | 5 | |
| α-helix | 362-374 | 13 | |
| α-helix | 379-386 | 8 | |
| α-helix | 398-412 | 15 | |
| α-helix | 419-429 | 11 | |
| α-helix | 437-453 | 17 | |
| α-helix | 460-472 | 13 | |
| α-helix | 477-488 | 12 | |
| α-helix | 495-507 | 13 | |
| α-helix | 511-524 | 14 | |
| α-helix | 529-532 | 4 | |
| α-helix | 533-541 | 9 | |
| α-helix | 545-558 | 14 | |
| α-helix | 565-577 | 13 | |
| α-helix | 581-594 | 14 | |
| α-helix | 602-605 | 4 | |
| α-helix | 607-611 | 5 | |
| α-helix | 615-628 | 14 | |
| α-helix | 635-645 | 11 | |
| α-helix | 650-663 | 14 | |
| α-helix | 674-687 | 14 | |
| α-helix | 693-706 | 14 | |
| α-helix | 708-711 | 4 | |
| β-strand | 713-715 | 3 | 9 |
| α-helix | 727-737 | 11 | |
| α-helix | 743-750 | 8 | |
| β-strand | 753-755 | 3 | 9 |
| β-strand | 757-758 | 2 | 10 |
| β-strand | 759-762 | 4 | 11 |
| β-strand | 767 | 1 | 11 |
| β-strand | 768-769 | 2 | 12 |
| α-helix | 770 | 1 | |
| β-strand | 772-776 | 5 | 13 |
| α-helix | 780-782 | 3 | |
| α-helix | 790-820 | 31 | |
| β-strand | 865-869 | 5 | 13 |
| β-strand | 872-873 | 2 | 10 |
| α-helix | 876-879 | 4 | |
| β-strand | 882-884 | 3 | 13 |
| β-strand | 891-892 | 2 | 11 |
| β-strand | 902-906 | 5 | 11 |
| β-strand | 916-917 | 2 | 12 |
| α-helix | 920-924 | 5 | |
Chain O: 23 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-17 | 10 | |
| α-helix | 23-35 | 13 | |
| α-helix | 38-48 | 11 | |
| α-helix | 57 | 1 | |
| α-helix | 58-62 | 5 | |
| α-helix | 63-67 | 5 | |
| α-helix | 75-87 | 13 | |
| α-helix | 93-117 | 25 | |
| α-helix | 123-138 | 16 | |
| α-helix | 143-159 | 17 | |
| α-helix | 165-182 | 18 | |
| α-helix | 185-197 | 13 | |
| α-helix | 207-222 | 16 | |
| α-helix | 230-234 | 5 | |
| α-helix | 237-240 | 4 | |
| α-helix | 246-248 | 3 | |
| α-helix | 250-260 | 11 | |
| α-helix | 263-276 | 14 | |
| α-helix | 279-282 | 4 | |
| α-helix | 284-302 | 19 | |
| β-strand | 307-309 | 3 | 16 |
| α-helix | 311-317 | 7 | |
| α-helix | 322-334 | 13 | |
| β-strand | 337-342 | 6 | 16 |
| β-strand | 347-353 | 7 | 16 |
| α-helix | 360-386 | 27 | |
Chain P: 27 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-19 | 15 | |
| α-helix | 21-28 | 8 | |
| α-helix | 32-42 | 11 | |
| α-helix | 48-67 | 20 | |
| α-helix | 72-78 | 7 | |
| α-helix | 81-85 | 5 | |
| α-helix | 92-107 | 16 | |
| α-helix | 111-125 | 15 | |
| α-helix | 132-149 | 18 | |
| α-helix | 153-166 | 14 | |
| α-helix | 173-190 | 18 | |
| α-helix | 193-200 | 8 | |
| α-helix | 207-209 | 3 | |
| α-helix | 214-230 | 17 | |
| α-helix | 234-246 | 13 | |
| α-helix | 248-252 | 5 | |
| α-helix | 254-270 | 17 | |
| α-helix | 272 | 1 | |
| α-helix | 275-286 | 12 | |
| α-helix | 288-292 | 5 | |
| α-helix | 295-303 | 9 | |
| α-helix | 311-318 | 8 | |
| β-strand | 327 | 1 | 15 |
| β-strand | 329 | 1 | 15 |
| α-helix | 332-338 | 7 | |
| α-helix | 341-356 | 16 | |
| β-strand | 357-361 | 5 | 16 |
| α-helix | 362-369 | 8 | |
| α-helix | 373-386 | 14 | |
| β-strand | 391-392 | 2 | 16 |
| β-strand | 393 | 1 | 17 |
| β-strand | 399-402 | 4 | 16 |
| α-helix | 408-439 | 32 | |
Chain Q: 26 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-15 | 14 | |
| α-helix | 20-38 | 19 | |
| α-helix | 51-65 | 15 | |
| α-helix | 72-77 | 6 | |
| α-helix | 78-80 | 3 | |
| α-helix | 81-88 | 8 | |
| α-helix | 93-106 | 14 | |
| α-helix | 110-123 | 14 | |
| α-helix | 131-147 | 17 | |
| α-helix | 151-161 | 11 | |
| α-helix | 172-187 | 16 | |
| α-helix | 192-204 | 13 | |
| α-helix | 212-228 | 17 | |
| α-helix | 234-248 | 15 | |
| α-helix | 250-251 | 2 | |
| α-helix | 255-272 | 18 | |
| α-helix | 276-281 | 6 | |
| α-helix | 287-290 | 4 | |
| α-helix | 294-308 | 15 | |
| α-helix | 311-319 | 9 | |
| α-helix | 322-327 | 6 | |
| α-helix | 329-351 | 23 | |
| β-strand | 354 | 1 | 17 |
| β-strand | 357-358 | 2 | 14 |
| α-helix | 359-366 | 8 | |
| α-helix | 370-383 | 14 | |
| β-strand | 388-391 | 4 | 14 |
| β-strand | 396-399 | 4 | 14 |
| α-helix | 402-403 | 2 | |
| α-helix | 407-431 | 25 | |
Chain R: 20 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-34 | 14 | |
| α-helix | 40-57 | 18 | |
| α-helix | 60-68 | 9 | |
| α-helix | 97-122 | 26 | |
| α-helix | 129-144 | 16 | |
| α-helix | 147-159 | 13 | |
| α-helix | 164-181 | 18 | |
| α-helix | 184-201 | 18 | |
| α-helix | 205-220 | 16 | |
| α-helix | 225-233 | 9 | |
| α-helix | 246-260 | 15 | |
| α-helix | 263-269 | 7 | |
| α-helix | 274-278 | 5 | |
| α-helix | 284-297 | 14 | |
| α-helix | 304-311 | 8 | |
| α-helix | 312-316 | 5 | |
| α-helix | 326-343 | 18 | |
| β-strand | 345-349 | 5 | 14 |
| α-helix | 350-357 | 8 | |
| α-helix | 361-374 | 14 | |
| β-strand | 379-382 | 4 | 14 |
| β-strand | 387-390 | 4 | 14 |
| α-helix | 396-423 | 28 | |
Chain S: 22 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-41 | 23 | |
| α-helix | 48-64 | 17 | |
| α-helix | 72-78 | 7 | |
| α-helix | 85-95 | 11 | |
| α-helix | 120-125 | 6 | |
| α-helix | 132-149 | 18 | |
| α-helix | 153-167 | 15 | |
| α-helix | 174-197 | 24 | |
| α-helix | 201-223 | 23 | |
| α-helix | 227-244 | 18 | |
| α-helix | 247-254 | 8 | |
| α-helix | 266-282 | 17 | |
| α-helix | 287-299 | 13 | |
| α-helix | 307-324 | 18 | |
| α-helix | 331-335 | 5 | |
| α-helix | 343-354 | 12 | |
| α-helix | 357-366 | 10 | |
| α-helix | 368-373 | 6 | |
| α-helix | 377-398 | 22 | |
| β-strand | 401-403 | 3 | 14 |
| α-helix | 404-410 | 7 | |
| α-helix | 416-429 | 14 | |
| β-strand | 434-437 | 4 | 14 |
| β-strand | 442-445 | 4 | 14 |
| α-helix | 456-488 | 33 | |
Chain T: 16 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-17 | 10 | |
| α-helix | 20-40 | 21 | |
| α-helix | 49-71 | 23 | |
| α-helix | 75-90 | 16 | |
| α-helix | 100-115 | 16 | |
| α-helix | 119-129 | 11 | |
| α-helix | 130-132 | 3 | |
| α-helix | 143-154 | 12 | |
| α-helix | 157-166 | 10 | |
| α-helix | 167-169 | 3 | |
| α-helix | 175-196 | 22 | |
| β-strand | 201 | 1 | 3 |
| α-helix | 202-209 | 8 | |
| α-helix | 214-223 | 10 | |
| β-strand | 228 | 1 | 4 |
| β-strand | 232 | 1 | 3 |
| β-strand | 233 | 1 | 4 |
| α-helix | 236-247 | 12 | |
| α-helix | 253-256 | 4 | |
| α-helix | 259-270 | 12 | |
Chain U: 8 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 7-10 | 4 | 18 |
| α-helix | 12-24 | 13 | |
| β-strand | 34-40 | 7 | 18 |
| β-strand | 45-53 | 9 | 18 |
| β-strand | 57-58 | 2 | 19 |
| β-strand | 66-67 | 2 | 19 |
| α-helix | 71-83 | 13 | |
| β-strand | 88-94 | 7 | 18 |
| α-helix | 103-113 | 11 | |
| α-helix | 117-118 | 2 | |
| β-strand | 119-123 | 5 | 18 |
| β-strand | 134-142 | 9 | 18 |
| β-strand | 151-157 | 7 | 18 |
| β-strand | 159 | 1 | 18 |
| α-helix | 165-174 | 10 | |
| α-helix | 186-214 | 29 | |
| α-helix | 223-234 | 12 | |
| α-helix | 242-297 | 56 | |
5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 26S proteasome regulatory subunit RPN10 | W | protein | 268 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P38886 (AlphaFold model) |
| Ubiquitin carboxyl-terminal hydrolase RPN11 | V | protein | 306 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P43588 (AlphaFold model) |
| 26S proteasome regulatory subunit RPN12 | T | protein | 274 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P32496 (AlphaFold model) |
| 26S proteasome regulatory subunit RPN13 | X | protein | 156 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | O13563 (AlphaFold model) |
| 26S proteasome complex subunit SEM1 | Y | protein | 89 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | O94742 |
| 26S proteasome regulatory subunit RPN1 | Z | protein | 993 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P38764 |
| 26S proteasome regulatory subunit RPN2 | N | protein | 945 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P32565 |
| 26S proteasome regulatory subunit RPN3 | S | protein | 523 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P40016 |
| 26S proteasome regulatory subunit RPN5 | P | protein | 445 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q12250 |
| 26S proteasome regulatory subunit RPN6 | Q | protein | 434 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q12377 |
| 26S proteasome regulatory subunit RPN7 | R | protein | 429 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q06103 |
| 26S proteasome regulatory subunit RPN8 | U | protein | 338 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q08723 |
1 more molecules are not listed.
Sequence of entity 1 (W), FASTA
>5MPE_1 26S proteasome regulatory subunit RPN10 (chains W)
MVLEATVLVIDNSEYSRNGDFPRTRFEAQIDSVEFIFQAKRNSNPENTVGLISGAGANPR
VLSTFTAEFGKILAGLHDTQIEGKLHMATALQIAQLTLKHRQNKVQHQRIVAFVCSPISD
SRDELIRLAKTLKKNNVAVDIINFGEIEQNTELLDEFIAAVNNPQEETSHLLTVTPGPRL
LYENIASSPIILEEGSSGMGAFGGSGGDSDANGTFMDFGVDPSMDPELAMALRLSMEEEQ
QRQERLRQQQQQQDQPEQSEQPEQHQDK
Sequence of entity 2 (V), FASTA
>5MPE_2 Ubiquitin carboxyl-terminal hydrolase RPN11 (chains V)
MERLQRLMMNSKVGSADTGRDDTKETVYISSIALLKMLKHGRAGVPMEVMGLMLGEFVDD
YTVNVVDVFAMPQSGTGVSVEAVDDVFQAKMMDMLKQTGRDQMVVGWYHSHPGFGCWLSS
VDVNTQKSFEQLNSRAVAVVVDPIQSVKGKVVIDAFRLIDTGALINNLEPRQTTSNTGLL
NKANIQALIHGLNRHYYSLNIDYHKTAKETKMLMNLHKEQWQSGLKMYDYEEKEESNLAA
TKSMVKIAEQYSKRIEEEKELTEEELKTRYVGRQDPKKHLSETADETLENNIVSVLTAGV
NSVAIK
Sequence of entity 3 (T), FASTA
>5MPE_3 26S proteasome regulatory subunit RPN12 (chains T)
MPSLAELTKSLSIAFENGDYAACEKLLPPIKIELIKNNLLIPDLSIQNDIYLNDLMITKR
ILEVGALASIQTFNFDSFENYFNQLKPYYFSNNHKLSESDKKSKLISLYLLNLLSQNNTT
KFHSELQYLDKHIKNLEDDSLLSYPIKLDRWLMEGSYQKAWDLLQSGSQNISEFDSFTDI
LKSAIRDEIAKNTELSYDFLPLSNIKALLFFNNEKETEKFALERNWPIVNSKVYFNNQSK
EKADYEDEMMHEEDQKTNIIEKAMDYAISIENIV
Sequence of entity 4 (X), FASTA
>5MPE_4 26S proteasome regulatory subunit RPN13 (chains X)
MSMSSTVIKFRAGVCEYNEDSRLCTPIPVQGEIEIKPNEEEELGFWDFEWRPTEKPVGRE
LDPISLILIPGETMWVPIKSSKSGRIFALVFSSNERYFFWLQEKNSGNLPLNELSAKDKE
IYNKMIGVLNNSSESDEEESNDEKQKAQDVDVSMQD
Sequence of entity 5 (Y), FASTA
>5MPE_5 26S proteasome complex subunit SEM1 (chains Y)
MSTDVAAAQAQSKIDLTKKKNEEINKKSLEEDDEFEDFPIDTWANGETIKSNAVTQTNIW
EENWDDVEVDDDFTNELKAELDRYKRENQ
Sequence of entity 6 (Z), FASTA
>5MPE_6 26S proteasome regulatory subunit RPN1 (chains Z)
MVDESDKKQQTIDEQSQISPEKQTPNKKDKKKEEEEQLSEEDAKLKTDLELLVERLKEDD
SSLYEASLNALKESIKNSTSSMTAVPKPLKFLRPTYPDLCSIYDKWTDPNLKSSLADVLS
ILAMTYSENGKHDSLRYRLLSDVSDFEGWGHEYIRHLALEIGEVYNDQVEKDAEDETSSD
GSKSDGSAATSGFEFSKEDTLRLCLDIVPYFLKHNGEEDAVDLLLEIESIDKLPQFVDEN
TFQRVCQYMVACVPLLPPPEDVAFLKTAYSIYLSQNELTDAIALAVRLGEEDMIRSVFDA
TSDPVMHKQLAYILAAQKTSFEYEGVQDIIGNGKLSEHFLYLAKELNLTGPKVPEDIYKS
HLDNSKSVFSSAGLDSAQQNLASSFVNGFLNLGYCNDKLIVDNDNWVYKTKGDGMTSAVA
SIGSIYQWNLDGLQQLDKYLYVDEPEVKAGALLGIGISASGVHDGEVEPALLLLQDYVTN
PDTKISSAAILGLGIAFAGSKNDEVLGLLLPIAASTDLPIETAAMASLALAHVFVGTCNG
DITTSIMDNFLERTAIELKTDWVRFLALALGILYMGQGEQVDDVLETISAIEHPMTSAIE
VLVGSCAYTGTGDVLLIQDLLHRLTPKNVKGEEDADEEETAEGQTNSISDFLGEQVNEPT
KNEEAEIEVDEMEVDAEGEEVEVKAEITEKKNGESLEGEEIKSEEKKGKSSDKDATTDGK
NDDEEEEKEAGIVDELAYAVLGIALIALGEDIGKEMSLRHFGHLMHYGNEHIRRMVPLAM
GIVSVSDPQMKVFDTLTRFSHDADLEVSMNSIFAMGLCGAGTNNARLAQLLRQLASYYSR
EQDALFITRLAQGLLHLGKGTMTMDVFNDAHVLNKVTLASILTTAVGLVSPSFMLKHHQL
FYMLNAGIRPKFILALNDEGEPIKVNVRVGQAVETVGQAGRPKKITGWITQSTPVLLNHG
ERAELETDEYISYTSHIEGVVILKKNPDYREEE
Sequence of entity 7 (N), FASTA
>5MPE_7 26S proteasome regulatory subunit RPN2 (chains N)
MSLTTAAPLLALLRENQDSVKTYALESINNVVDQLWSEISNELPDIEALYDDDTFSDREM
AALIASKVYYNLGEYESAVKYALAAKDRFDIDEKSQFVETIVSKSIEMYVQEASKQYTKD
EQFYTKDIIDPKLTSIFERMIEKCLKASELKLALGIALEGYRLDIIESALKSKLDQDSTS
ENVKIINYLLTLAITTVTNSKFRSSILRKSFDFLMNMPNCDYLTLNKVVVNLNDAGLALQ
LFKKLKEENDEGLSAQIAFDLVSSASQQLLEILVTELTAQGYDPALLNILSGLPTCDYYN
TFLLNNKNIDIGLLNKSKSSLDGKFSLFHTAVSVANGFMHAGTTDNSFIKANLPWLGKAQ
NWAKFTATASLGVIHKGNLLEGKKVMAPYLPGSRASSRFIKGGSLYGLGLIYAGFGRDTT
DYLKNIIVENSGTSGDEDVDVLLHGASLGIGLAAMGSANIEVYEALKEVLYNDSATSGEA
AALGMGLCMLGTGKPEAIHDMFTYSQETQHGNITRGLAVGLALINYGRQELADDLITKML
ASDESLLRYGGAFTIALAYAGTGNNSAVKRLLHVAVSDSNDDVRRAAVIALGFVLLRDYT
TVPRIVQLLSKSHNAHVRCGTAFALGIACAGKGLQSAIDVLDPLTKDPVDFVRQAAMIAL
SMILIQQTEKLNPQVADINKNFLSVITNKHQEGLAKFGACVAQGIMNAGGRNVTIQLENA
DTGTLDTKSVVGLVMFSQFWYWFPLAHFLSLSFTPTTVIGIRGSDQAIPKFQMNCYAKED
AFSYPRMYEEASGKEVEKVATAVLSTTARAKARAKKTKKEKGPNEEEKKKEHEEKEKERE
TNKKGIKETKENDEEFYKNKYSSKPYKVDNMTRILPQQSRYISFIKDDRFVPVRKFKGNN
GVVVLRDREPKEPVALIETVRQMKDVNAPLPTPFKVDDNVDFPSA
Sequence of entity 8 (S), FASTA
>5MPE_8 26S proteasome regulatory subunit RPN3 (chains S)
MASTAVMMDVDSSGVNDLHHSEKKYAEEDQVQELLKVLNEISKTTLTLDPRYIWRSLKDL
SSLRNQELLNAETLCFTVNVLYPDSSSFKKNLLKFITSNHKSSVPGSAELRNSYPASFYS
VNTEKKTIEVTAEINCFMHLLVQLFLWDSKELEQLVEFNRKVVIPNLLCYYNLRSLNLIN
AKLWFYIYLSHETLARSSEEINSDNQNIILRSTMMKFLKIASLKHDNETKAMLINLILRD
FLNNGEVDSASDFISKLEYPHTDVSSSLEARYFFYLSKINAIQLDYSTANEYIIAAIRKA
PHNSKSLGFLQQSNKLHCCIQLLMGDIPELSFFHQSNMQKSLLPYYHLTKAVKLGDLKKF
TSTITKYKQLLLKDDTYQLCVRLRSNVIKTGIRIISLTYKKISLRDICLKLNLDSEQTVE
YMVSRAIRDGVIEAKINHEDGFIETTELLNIYDSEDPQQVFDERIKFANQLHDEYLVSMR
YPEDKKTQQNEKSENGENDDDTLDGDLMDDMSDISDLDDLGFL
Sequence of entity 9 (P), FASTA
>5MPE_9 26S proteasome regulatory subunit RPN5 (chains P)
MSRDAPIKADKDYSQILKEEFPKIDSLAQNDCNSALDQLLVLEKKTRQASDLASSKEVLA
KIVDLLASRNKWDDLNEQLTLLSKKHGQLKLSIQYMIQKVMEYLKSSKSLDLNTRISVIE
TIRVVTENKIFVEVERARVTKDLVEIKKEEGKIDEAADILCELQVETYGSMEMSEKIQFI
LEQMELSILKGDYSQATVLSRKILKKTFKNPKYESLKLEYYNLLVKISLHKREYLEVAQY
LQEIYQTDAIKSDEAKWKPVLSHIVYFLVLSPYGNLQNDLIHKIQNDNNLKKLESQESLV
KLFTTNELMRWPIVQKTYEPVLNEDDLAFGGEANKHHWEDLQKRVIEHNLRVISEYYSRI
TLLRLNELLDLTESQTETYISDLVNQGIIYAKVNRPAKIVNFEKPKNSSQLLNEWSHNVD
ELLEHIETIGHLITKEEIMHGLQAK
Sequence of entity 10 (Q), FASTA
>5MPE_10 26S proteasome regulatory subunit RPN6 (chains Q)
MSLPGSKLEEARRLVNEKQYNEAEQVYLSLLDKDSSQSSAAAGASVDDKRRNEQETSILE
LGQLYVTMGAKDKLREFIPHSTEYMMQFAKSKTVKVLKTLIEKFEQVPDSLDDQIFVCEK
SIEFAKREKRVFLKHSLSIKLATLHYQKKQYKDSLALINDLLREFKKLDDKPSLVDVHLL
ESKVYHKLRNLAKSKASLTAARTAANSIYCPTQTVAELDLMSGILHCEDKDYKTAFSYFF
ESFESYHNLTTHNSYEKACQVLKYMLLSKIMLNLIDDVKNILNAKYTKETYQSRGIDAMK
AVAEAYNNRSLLDFNTALKQYEKELMGDELTRSHFNALYDTLLESNLCKIIEPFECVEIS
HISKIIGLDTQQVEGKLSQMILDKIFYGVLDQGNGWLYVYETPNQDATYDSALELVGQLN
KVVDQLFEKASVLY
Sequence of entity 11 (R), FASTA
>5MPE_11 26S proteasome regulatory subunit RPN7 (chains R)
MVDVEEKSQEVEYVDPTVNRVPNYEVSEKAFLLTQSKVSIEQRKEAAEFVLAKIKEEEMA
PYYKYLCEEYLVNNGQSDLEHDEKSDSLNEWIKFDQELYNELCKKNESKIKELNEKIQKL
EEDDEGELEQAQAWINLGEYYAQIGDKDNAEKTLGKSLSKAISTGAKIDVMLTIARLGFF
YNDQLYVKEKLEAVNSMIEKGGDWERRNRYKTYYGIHCLAVRNFKEAAKLLVDSLATFTS
IELTSYESIATYASVTGLFTLERTDLKSKVIDSPELLSLISTTAALQSISSLTISLYASD
YASYFPYLLETYANVLIPCKYLNRHADFFVREMRRKVYAQLLESYKTLSLKSMASAFGVS
VAFLDNDLGKFIPNKQLNCVIDRVNGIVETNRPDNKNAQYHLLVKQGDGLLTKLQKYGAA
VRLTGSDRV
Sequence of entity 12 (U), FASTA
>5MPE_12 26S proteasome regulatory subunit RPN8 (chains U)
MSLQHEKVTIAPLVLLSALDHYERTQTKENKRCVGVILGDANSSTIRVTNSFALPFEEDE
KNSDVWFLDHNYIENMNEMCKKINAKEKLIGWYHSGPKLRASDLKINELFKKYTQNNPLL
LIVDVKQQGVGLPTDAYVAIEQVKDDGTSTEKTFLHLPCTIEAEEAEEIGVEHLLRDVRD
QAAGGLSIRLTNQLKSLKGLQSKLKDVVEYLDKVINKELPINHTILGKLQDVFNLLPNLG
TPDDDEIDVENHDRINISNNLQKALTVKTNDELMVIYISNLVRSIIAFDDLIENKIQNKK
IQEQRVKDKQSKVSDDSESESGDKEATAPLIQRKNKKN
Primary citation
Structural insights into the functional cycle of the ATPase module of the 26S proteasome. Wehmer, M., Rudack, T., Beck, F. et al. Proc Natl Acad Sci U S A (2017) 114:1305-1310. DOI 10.1073/pnas.1621129114 · PubMed
Other PDB entries of the same protein (UniProt P38886 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5LN1 3.14 Å, Structure of ubiquitylated-RPN10 from yeast;
- 9CGC 3.61 Å, Yeast 26S proteasome non-substrate-engaged (S1 state)
- 6J2Q 3.8 Å, Yeast proteasome in Ub-accepted state (C1-b)
- 6J2X 3.8 Å, Yeast proteasome in resting state (C1-a)
- 5MPD 4.1 Å, 26S proteasome in presence of ATP (s1)
- 6FVT 4.1 Å, 26S proteasome, s1 state
- 5WVK 4.2 Å, Yeast proteasome-ADP-AlFx
- 6FVU 4.5 Å, 26S proteasome, s2 state
- 6FVW 4.5 Å, 26S proteasome, s4 state
- 6J30 4.5 Å, yeast proteasome in Ub-engaged state (C2)
- 3JCP 4.6 Å, Structure of yeast 26S proteasome in M2 state derived from Titan dataset
- 3JCO 4.8 Å, Structure of yeast 26S proteasome in M1 state derived from Titan dataset
Browse structure collections
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