Crystal structure of glycopeptide "GVTSAfPDT*RPAP" in complex with scFv-SM3. Determined by X-ray diffraction at 1.85 Å resolution. Released 13 Dec 2017.
Explore 5OWP in 3D Show helices and sheets RCSB PDB PDBe
5OWP contains 7 α-helices and 23 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3-7 | 5 | 1 |
| β-strand | 10-12 | 3 | 2 |
| β-strand | 18-25 | 8 | 1 |
| α-helix | 29-31 | 3 | |
| β-strand | 34-40 | 7 | 2 |
| β-strand | 44-51 | 8 | 2 |
| α-helix | 54-56 | 3 | |
| β-strand | 60-62 | 3 | 2 |
| β-strand | 70-75 | 6 | 1 |
| α-helix | 76-78 | 3 | |
| β-strand | 80-85 | 6 | 1 |
| α-helix | 90-92 | 3 | |
| β-strand | 94-100 | 7 | 2 |
| β-strand | 108-109 | 2 | 2 |
| β-strand | 113-117 | 5 | 2 |
| β-strand | 1011-1013 | 3 | 3 |
| β-strand | 1016-1019 | 4 | 4 |
| β-strand | 1024-1031 | 8 | 3 |
| β-strand | 1034 | 1 | 3 |
| α-helix | 1038-1040 | 3 | |
| β-strand | 1043-1048 | 6 | 4 |
| β-strand | 1052-1058 | 7 | 4 |
| β-strand | 1062-1063 | 2 | 4 |
| α-helix | 1064 | 1 | |
| β-strand | 1071-1076 | 6 | 3 |
| β-strand | 1079-1085 | 7 | 3 |
| α-helix | 1089-1091 | 3 | |
| β-strand | 1093-1101 | 9 | 4 |
| β-strand | 1104-1107 | 4 | 4 |
| β-strand | 1111-1115 | 5 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Ig heavy chain V-III region J606,Ig lambda-1 chain V region H2020 | H | protein | 244 | Mus musculus | P01726 (AlphaFold model), P01801 (AlphaFold model) |
| 5,6-dihydro-benzo[h]cinnolin-3-ylamine | D | protein | 8 | synthetic construct |
>5OWP_1 Ig heavy chain V-III region J606,Ig lambda-1 chain V region H2020 (chains H) QVQLQESGGGLVQPGGSMKLSCVASGFTFSNYWMNWVRQSPEKGLEWVAEIRLKSNNYAT HYAESVKGRFTISRDDSKSSVYLQMNNLRAEDTGIYYCTGVGQFAYWGQGTTVTVSSSSG GGGSGGGGGSSGSSDIVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLF TGLIGGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKL TVLG
>5OWP_2 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE (chains D) SAPDTRPA
| ID | Name | Formula | Copies |
|---|---|---|---|
| A2G | 2-acetamido-2-deoxy-alpha-D-galactopyranose | C8 H15 N O6 | 1 |
Water and common crystallization additives (EDO) are not listed.
The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer. Somovilla, V.J., Bermejo, I.A., Albuquerque, I.S. et al. J Am Chem Soc (2017) 139:18255-18261. DOI 10.1021/jacs.7b09447 · PubMed
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