5PAC: Human factor VIIa

human factor VIIa in complex with 5-hydroxy-N-(4-oxo-3H-quinazolin-6-yl)-1-[3-[(phenylcarbamoylamino)methyl]phenyl]pyrazole-4-carboxamide at 1.50A. Determined by X-ray diffraction at 1.5 Å resolution. Released 21 Jun 2017.

Method: X-ray diffraction
Resolution: 1.5 Å
Organism: Homo sapiens
Chains: 2
Atoms: 2,908
Mol. weight: 36.04 kDa
Ligands: CA, 7Y7
Released: 21 Jun 2017

Explore 5PAC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5PAC contains 14 α-helices and 27 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	154-157	4
β-strand	161-165	5	1
β-strand	169-173	5	1
β-strand	178-180	3	2
β-strand	187-189	3	2
α-helix	199-202	4

Chain B: 12 helices, 23 β-strands

Element	Residues	Length	Sheet
β-strand	214	1	3
β-strand	217-218	2	4
β-strand	227-232	6	5
β-strand	235-244	10	5
β-strand	247-250	4	5
α-helix	252-255	4
α-helix	261-263	3
β-strand	264-268	5	5
β-strand	272	1	6
β-strand	281-291	11	5
β-strand	304-308	5	5
α-helix	311-314	4
β-strand	315	1	7
β-strand	318	1	7
α-helix	320-321	2
β-strand	322	1	4
α-helix	326-331	6
α-helix	333-335	3
β-strand	338-343	6	4
β-strand	346	1	8
α-helix	352	1
β-strand	353	1	8
α-helix	354	1
β-strand	356	1	6
β-strand	358-365	8	4
α-helix	367-373	7
β-strand	387-390	4	4
β-strand	398	1	3
β-strand	407-412	6	4
β-strand	415-422	8	4
β-strand	435-439	5	4
α-helix	440-443	4
α-helix	444-451	8
α-helix	454-455	2
β-strand	460-463	4	5

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Coagulation factor VII light chain	A	protein	64	Homo sapiens	P08709 (AlphaFold model)
Coagulation factor VII heavy chain	B	protein	254	Homo sapiens	P08709 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>5PAC_1 Coagulation factor VII light chain (chains A)
LICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASK
PQGR

Sequence of entity 2 (B), FASTA

>5PAC_2 Coagulation factor VII heavy chain (chains B)
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHD
LSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERT
LAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGY
SDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMR
SEPRPGVLLRAPFP

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	1
7Y7	5-hydroxy-N-(4-oxo-3H-quinazolin-6-yl)-1-[3-[(phenylcarbamoylamino)methyl]pheny…	C26 H21 N7 O4	1

Water and common crystallization additives (SO4, CL, GOL) are not listed.

Primary citation

Crystal Structure of a Factor VIIa complex. Mayweg, A., Roever, S., Rudolph, M.G. To be published.

Other PDB entries of the same protein (UniProt P08709 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6R2W 1.25 Å, Crystal structure of the super-active FVIIa variant VYT in complex with tissue factor
5PAG 1.36 Å, Crystal Structure of Factor VIIa in complex with (2R)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-py…
5PAX 1.36 Å, Crystal Structure of Factor VIIa in complex with 1-(2,6-difluorophenyl)-3-[[3-[5-hydroxy-…
4YLQ 1.4 Å, Crystal Structure of a FVIIa-Trypsin Chimera (FT) in Complex with Soluble Tissue Factor
5PAO 1.4 Å, Crystal Structure of Factor VIIa in complex with (2S)-2,3-dihydroxy-N-[[3-[5-hydroxy-4-(1…
5PAV 1.4 Å, Crystal Structure of Factor VIIa in complex with N-(6-aminopyridin-3-yl)-5-hydroxy-1-phen…
5L0S 1.45 Å, human POGLUT1 in complex with Factor VII EGF1 and UDP
5PAE 1.45 Å, Crystal Structure of Factor VIIa in complex with (2S)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-py…
5PB2 1.45 Å, Crystal Structure of Factor VIIa in complex with 2-phenyl-4-(1H-pyrrolo[3,2-c]pyridin-2-y…
5PAS 1.48 Å, Crystal Structure of Factor VIIa in complex with (2S)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-py…
5PAF 1.5 Å, Crystal Structure of Factor VIIa in complex with N-(2-amino-1H-benzimidazol-5-yl)-2-[3-[(…
4JZE 1.52 Å, Structure of factor VIIA in complex with the inhibitor 2-{2-[(1-aminoisoquinolin-6-yl)car…

Browse structure collections

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