5W1S: Escherichia coli RNA polymerase and TraR complex

X-ray crystal structure of Escherichia coli RNA polymerase and TraR complex. Determined by X-ray diffraction at 3.81 Å resolution. Released 14 Jun 2017.

Method
X-ray diffraction
Resolution
3.81 Å
Organism
Escherichia coli (strain K12)
Chains
14
Atoms
56,825
Mol. weight
938.56 kDa
Ligands
ZN, MG
Released
14 Jun 2017

Explore 5W1S in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5W1S contains 336 α-helices and 388 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 22 β-strands

ElementResiduesLengthSheet
β-strand13-2081
β-strand23-2861
β-strand3112
α-helix35-4814
β-strand52-61103
β-strand7414
α-helix78-858
β-strand90-9125
β-strand98-10583
β-strand109-11136
α-helix112-1143
β-strand11513
β-strand122-12325
β-strand129-13246
β-strand13314
β-strand139-150123
β-strand151-15337
α-helix155-1584
β-strand170-17233
β-strand175-17737
β-strand180-18671
β-strand18912
β-strand19912
β-strand202-20761
α-helix213-23220
α-helix251-2544
β-strand25618
α-helix257-2604
α-helix264-2729
β-strand27718
α-helix278-2814
α-helix287-2904
α-helix297-3015
α-helix303-3108
Chain B: 4 helices, 13 β-strands
ElementResiduesLengthSheet
β-strand14-1749
β-strand23-3199
α-helix321
α-helix35-4814
β-strand52-60910
α-helix78-869
β-strand90-92310
β-strand99-101310
β-strand110111
β-strand121-123310
β-strand131111
β-strand143-150810
β-strand152-153212
β-strand175-176212
β-strand180-190119
β-strand198-207109
α-helix213-22614
Chain C: 57 helices, 98 β-strands
ElementResiduesLengthSheet
β-strand13-14213
α-helix19-202
α-helix29-3810
α-helix49-568
α-helix571
β-strand59-60214
β-strand66-751014
α-helix76-783
α-helix82-887
β-strand93-1051314
β-strand113-117514
β-strand122-128714
β-strand136-137215
β-strand142-145415
β-strand147-151516
α-helix1521
β-strand154-158517
β-strand173-177517
β-strand180118
β-strand184-187417
β-strand195-198417
β-strand204-205217
α-helix208-2125
α-helix217-2248
β-strand228-231419
β-strand238-240319
β-strand250120
β-strand255-257321
β-strand260-263421
β-strand268120
α-helix271-28010
β-strand284-286319
α-helix291-2933
α-helix2951
β-strand296-297219
β-strand301-302222
β-strand309-311322
β-strand315-316219
α-helix319-3268
β-strand332-335419
α-helix346-3516
α-helix359-37012
α-helix378-38912
β-strand396118
α-helix398-40811
α-helix422-43716
β-strand451-454416
α-helix456-48126
α-helix496-50712
β-strand509115
β-strand512-514315
α-helix520-5278
β-strand529123
β-strand530-531216
α-helix545-5484
α-helix550-5512
α-helix552-5543
β-strand558124
β-strand574123
β-strand575124
β-strand576125
β-strand580-581226
β-strand587-595926
β-strand598-6071026
α-helix608-6136
β-strand616126
β-strand623-624226
β-strand628-629226
β-strand633-637526
β-strand642-646526
β-strand652-654326
β-strand662125
α-helix663-6664
α-helix671-6733
β-strand674127
α-helix676-68510
α-helix686-6883
β-strand689128
α-helix690-6923
β-strand700-701213
α-helix705-7117
β-strand716-717229
β-strand722-727630
β-strand731-736630
β-strand748-752530
α-helix753-7542
β-strand757-758231
β-strand763132
β-strand764-765231
β-strand768-769229
β-strand776-777230
β-strand782-785429
β-strand789-790233
β-strand793-794233
β-strand798-804734
β-strand816-819434
α-helix820-8245
β-strand830-8411232
β-strand842-843235
β-strand846-847235
β-strand849136
α-helix859-8624
β-strand865137
β-strand870138
β-strand871137
α-helix8721
β-strand876-877232
β-strand882-884338
β-strand887-889336
α-helix897-90610
β-strand913-915336
β-strand918-919238
α-helix920-9212
β-strand926-9351032
α-helix940-9412
α-helix943-97937
α-helix986-9894
α-helix994-9963
α-helix1006-103732
α-helix1039-10413
β-strand1046-10581332
β-strand1065-1068434
β-strand1073-1080834
α-helix1082-10843
β-strand1087139
β-strand1093139
β-strand1096-1098334
α-helix1100-11023
β-strand1108127
α-helix1110-113324
α-helix1138-114811
α-helix1167-117610
β-strand1182-1183213
α-helix1192-120110
β-strand1209-1210240
β-strand1213139
α-helix12191
β-strand1220139
α-helix12211
β-strand1225-1226240
β-strand1227-1234834
β-strand1235128
α-helix1239-12424
β-strand1244-1246341
β-strand1250-1251242
β-strand1252143
β-strand1258-1259242
α-helix1265-12684
β-strand1269144
α-helix1272-12809
α-helix1284-12907
α-helix1298-131013
α-helix1321-133111
β-strand1335145
β-strand1338-1339246
Chain D: 61 helices, 61 β-strands
ElementResiduesLengthSheet
β-strand20-21246
β-strand24145
α-helix27-337
β-strand34-37447
β-strand40148
β-strand44149
α-helix501
β-strand51149
α-helix521
β-strand55148
β-strand84150
β-strand91150
α-helix97-1004
β-strand102-1121147
α-helix114-1185
α-helix123-1275
α-helix132-1398
β-strand144-147451
β-strand159-160251
α-helix162-17110
β-strand177-179351
α-helix182-19110
α-helix194-20714
α-helix211-23020
α-helix234-2374
β-strand238-244747
α-helix247-2493
β-strand254152
α-helix256-2583
β-strand260152
β-strand261-262253
α-helix264-28421
α-helix289-30820
α-helix3151
β-strand316154
α-helix3171
β-strand323154
α-helix324-3252
α-helix327-3315
β-strand346144
β-strand350-354541
β-strand355-356255
β-strand365-369555
α-helix370-3767
α-helix378-38710
α-helix394-40310
α-helix406-41611
β-strand421-425541
α-helix431-4333
β-strand434-437441
β-strand438-442555
β-strand447-448255
α-helix454-4574
β-strand465-469541
α-helix474-4829
β-strand485141
α-helix486-4883
β-strand491156
β-strand498156
α-helix505-5139
β-strand526-527257
α-helix530-5389
β-strand547-5561057
β-strand558158
β-strand562158
β-strand564-5731057
α-helix574-5807
α-helix589-5924
α-helix598-61215
α-helix614-63522
α-helix641-6433
α-helix645-6473
α-helix650-66920
α-helix675-70329
β-strand706159
β-strand715159
α-helix721-7288
α-helix734-7407
β-strand748160
β-strand754160
α-helix766-7672
α-helix769-80335
β-strand809161
β-strand820-822362
α-helix835-8395
β-strand843163
β-strand844162
α-helix8471
β-strand848-849264
β-strand856-858364
β-strand863163
α-helix866-8749
β-strand880-882362
β-strand894161
α-helix896-8994
α-helix908-9103
α-helix915-92410
α-helix925-9295
α-helix1138-11458
α-helix1148-11503
β-strand1156165
β-strand1161-1166666
β-strand1173-1178666
β-strand1187-1190466
β-strand1196167
β-strand1203-1204266
β-strand1209165
β-strand1211167
α-helix1217-12193
α-helix1220-12245
α-helix1226-124318
α-helix1250-126011
β-strand1263-1265368
β-strand1277-1279368
α-helix1280-129112
β-strand1304-1305268
α-helix1309-13146
α-helix1319-13257
α-helix1328-133811
β-strand1341-1342246
α-helix1347-13526
α-helix1360-137011
Chain E: 6 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix7-126
α-helix18-3114
α-helix46-5510
α-helix61-7818
α-helix80-834
α-helix87-893
Chain F: 27 helices, 6 β-strands
ElementResiduesLengthSheet
α-helix97-10610
α-helix109-1124
α-helix115-13521
α-helix138-15215
α-helix158-1614
β-strand162-165469
α-helix214-23320
α-helix245-25612
β-strand259-261369
α-helix263-28826
α-helix289-2935
α-helix328-3314
α-helix334-3396
α-helix342-3509
α-helix355-38228
α-helix384-3918
α-helix401-41818
α-helix421-4233
α-helix427-44620
α-helix454-47320
α-helix483-4864
α-helix493-5019
α-helix503-5042
β-strand505-506253
β-strand510170
β-strand518170
α-helix519-5224
β-strand524143
α-helix531-54919
α-helix553-56210
α-helix573-5786
α-helix585-59713
α-helix604-6085
Chain G: 7 helices, 15 β-strands
ElementResiduesLengthSheet
β-strand13-18671
β-strand24-31871
α-helix321
α-helix35-4915
β-strand53-61972
α-helix78-869
β-strand90-92373
β-strand97-105972
β-strand108-110374
α-helix112-1143
β-strand115172
α-helix116-1183
β-strand121-123373
β-strand131-133374
β-strand139-1491172
β-strand151-153375
α-helix156-1583
β-strand170-172372
β-strand175-177375
β-strand180-1901171
β-strand198-2071071
α-helix213-22715
Chain H: 4 helices, 15 β-strands
ElementResiduesLengthSheet
β-strand15-17376
β-strand23-31976
α-helix321
α-helix35-4814
β-strand53-60877
α-helix78-869
β-strand90-92378
β-strand99-103577
β-strand110-111279
β-strand115177
β-strand121-123378
β-strand129-131379
β-strand141-149977
β-strand152-153280
β-strand172177
β-strand175-176280
β-strand180-1921376
β-strand195-2071376
α-helix213-22715

6 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
DNA-directed RNA polymerase subunit alphaA, B, G, Hprotein329Escherichia coli (strain K12)P0A7Z4 (AlphaFold model)
DNA-directed RNA polymerase subunit betaC, Iprotein1342Escherichia coli (strain K12)P0A8V2 (AlphaFold model)
DNA-directed RNA polymerase subunit beta'D, Jprotein1407Escherichia coli (strain K12)P0A8T7 (AlphaFold model)
DNA-directed RNA polymerase subunit omegaE, Kprotein91Escherichia coli (strain K12)P0A800 (AlphaFold model)
RNA polymerase sigma factor RpoDF, Lprotein613Escherichia coli (strain K12)P00579
Protein TraRM, Nprotein79Escherichia coli (strain K12)P41065
Sequence of entity 1 (A, B, G, H), FASTA
>5W1S_1 DNA-directed RNA polymerase subunit alpha (chains A, B, G, H)
MQGSVTEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRILLSSMPGCAVTEVE
IDGVLHEYSTKEGVQEDILEILLNLKGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGD
VEIVKPQHVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERPIGRLLVDACYSPV
ERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAIRRAATILAEQLEAFVDLRDVRQP
EVKEEKPEFDPILLRPVDDLELTVRSANCLKAEAIHYIGDLVQRTEVELLKTPNLGKKSL
TEIKDVLASRGLSLGMRLENWPPASIADE
Sequence of entity 2 (C, I), FASTA
>5W1S_2 DNA-directed RNA polymerase subunit beta (chains C, I)
MVYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQYGLEAAFRSVFPIQ
SYSGNSELQYVSYRLGEPVFDVQECQIRGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQ
EVYMGEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSSGKVLYNARIIPYR
GSWLDFEFDPKDNLFVRIDRRRKLPATIILRALNYTTEQILDLFFEKVIFEIRDNKLQME
LVPERLRGETASFDIEANGKVYVEKGRRITARHIRQLEKDDVKLIEVPVEYIAGKVVAKD
YIDESTGELICAANMELSLDLLAKLSQSGHKRIETLFTNDLDHGPYISETLRVDPTNDRL
SALVEIYRMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLLREEIEGSGIL
SKDDIIDVMKKLIDIRNGKGEVDDIDHLGNRRIRSVGEMAENQFRVGLVRVERAVKERLS
LGDLDTLMPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRISALGPGGLTR
ERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLSVYAQTNEYGFLETPYRKVTDGVVT
DEIHYLSAIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSRDQVDYMDVSTQQV
VSVGASLIPFLEHDDANRALMGANMQRQAVPTLRADKPLVGTGMERAVAVDSGVTAVAKR
GGVVQYVDASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPCVSLGEPVERG
DVLADGPSTDLGELALGQNMRVAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELACVS
RDTKLGPEEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPKGETQLTPEEK
LLRAIFGEKASDVKDSSLRVPNGVSGTVIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDL
SEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDE
LKHEFEKKLEAKRRKITQGDDLAPGVLKIVKVYLAVKRRIQPGDKMAGRHGNKGVISKIN
PIEDMPYDENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINAMLKQQQEVAK
LREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKGMPIATPVFDGAKEAEIKELLK
LGDLPTSGQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLG
GKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMP
ESFNVLLKEIRSLGINIELEDE
Sequence of entity 3 (D, J), FASTA
>5W1S_3 DNA-directed RNA polymerase subunit beta' (chains D, J)
MKDLLKFLKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGLFCAR
IFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTKVRRERMGHIELASPTAHIWFLKSL
PSRIGLLLDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQYLDALEEFGDEFDAKM
GAEAIQALLKSMDLEQECEQLREELNETNSETKRKKLTKRIKLLEAFVQSGNKPEWMILT
VLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEKRMLQ
EAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVITVGPY
LRLHQCGLPKKMALELFKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIREHP
VLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAYNADFDGDQMAVHVPLTLEAQLEA
RALMMSTNNILSPANGEPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERLYRSG
LASLHARVKVRITEYEKDANGELVAKTSLKDTTVGRAILWMIVPKGLPYSIVNQALGKKA
ISKMLNTCYRILGLKPTVIFADQIMYTGFAYAARSGASVGIDDMVIPEKKHEIISEAEAE
VAEIQEQFQSGLVTAGERYNKVIDIWAAANDRVSKAMMDNLQTETVINRDGQEEKQVSFN
SIYMMADSGARGSAAQIRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTHGAR
KGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTHEGIMMTPVIEGGDVKEPLRDRVL
GRVTAEDVLKPGTADILVPRNTLLHEQWCDLLEENSVDAVKVRSVVSCDTDFGVCAHCYG
RDLARGHIINKGEAIGVIAAQSIGEPGTQLTMRTFHIGGAASRAAAESSIQVKNKGSIKL
SNVKSVVNSSGKLVITSRNTELKLIDEFGRTKESYKVPYGAVLAKGDGEQVAGGETVANW
DPHTMPVITEVSGFVRFTDMIDGQTITRQTDELTGLSSLVVLDSAERTAGGKDLRPALKI
VDAQGNDVLIPGTDMPAQYFLPGKAIVQLEDGVQISSGDTLARIPQESGGTKDITGGLPR
VADLFEARRPKEPAILAEISGIVSFGKETKGKRRLVITPVDGSDPYEEMIPKWRQLNVFE
GERVERGDVISDGPEAPHDILRLRGVHAVTRYIVNEVQDVYRLQGVKINDKHIEVIVRQM
LRKATIVNAGSSDFLEGEQVEYSRVKIANRELEANGKVGATYSRDLLGITKASLATESFI
SAASFQETTRVLTEAAVAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRAAGEAPA
APQVTAEDASASLAELLNAGLGGSDNE
Sequence of entity 4 (E, K), FASTA
>5W1S_4 DNA-directed RNA polymerase subunit omega (chains E, K)
MARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPEENDKTTVIALREIEEGLIN
NQILDVRERQEQQEQEAAELQAVTAIAEGRR
Sequence of entity 5 (F, L), FASTA
>5W1S_5 RNA polymerase sigma factor RpoD (chains F, L)
MEQNPQSQLKLLVTRGKEQGYLTYAEVNDHLPEDIVDSDQIEDIIQMINDMGIQVMEEAP
DADDLMLAENTADEDAAEAAAQVLSSVESEIGRTTDPVRMYMREMGTVELLTREGEIDIA
KRIEDGINQVQCSVAEYPEAITYLLEQYDRVEAEEARLSDLITGFVDPNAEEDLAPTATH
VGSELSQEDLDDDEDEDEEDGDDDSADDDNSIDPELAREKFAELRAQYVVTRDTIKAKGR
SHATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMPKK
NFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIEQVKD
INRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFE
YRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTP
EELAERMLMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESL
RAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRKLRH
PSRSEVLRSFLDD
Sequence of entity 6 (M, N), FASTA
>5W1S_6 Protein TraR (chains M, N)
MSDEADEAYSVTEQLTMTGINRIRQKINAHGIPVYLCEACGNPIPEARRKIFPGVTLCVE
CQAYQERQRKHYAHHHHHH

Ligands and cofactors

IDNameFormulaCopies
ZNZinc ionZn6
MGMagnesium ionMg2

Primary citation

Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Molodtsov, V., Sineva, E., Zhang, L. et al. Mol Cell (2018) 69:828-839.e5. DOI 10.1016/j.molcel.2018.01.035 · PubMed

Other PDB entries of the same protein (UniProt P0A7Z4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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