5XX2: A BPTI-[5,55] variant with C14GA38L mutations

A BPTI-[5,55] variant with C14GA38L mutations. Determined by X-ray diffraction at 1.12 Å resolution. Released 4 Jul 2018.

Method: X-ray diffraction
Resolution: 1.12 Å
Organism: Bos taurus
Chains: 2
Atoms: 1,315
Mol. weight: 13.4 kDa
Released: 4 Jul 2018

Explore 5XX2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5XX2 contains 6 α-helices and 6 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A and B: 3 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	3-6	4
α-helix	8-9	2
β-strand	18-24	7	1
β-strand	29-35	7	1
β-strand	45	1	1
α-helix	48-55	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Pancreatic trypsin inhibitor	A, B	protein	58	Bos taurus	P00974 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>5XX2_1 Pancreatic trypsin inhibitor (chains A, B)
RPDFCLEPPYTGPGKARIIRYFYNAKAGLAQTFVYGGLRAKRNNFKSAEDALRTCGGA

Primary citation

Hydrophobic surface residues can stabilize a protein through improved water-protein interactions. Islam, M.M., Kobayashi, K., Kidokoro, S.I. et al. FEBS J (2019). DOI 10.1111/febs.14941 · PubMed

Other PDB entries of the same protein (UniProt P00974 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1G6X 0.86 Å, Ultra high resolution structure of bovine pancreatic trypsin inhibitor (BPTI) mutant…
1K6U 1.0 Å, Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor
5PTI 1.0 Å, Structure of bovine pancreatic trypsin inhibitor. Results of joint neutron and X-ray…
1BPI 1.09 Å, The structure of bovine pancreatic trypsin inhibitor at 125K: definition of…
2ZJX 1.09 Å, Bovine pancreatic trypsin inhibitor (BPTI) containing only the [5,55] disulfide bond
2ZVX 1.09 Å, Structure of a BPTI-[5,55] variant containing Gly/Val at the 14/38th positions
5XX3 1.12 Å, A BPTI-[5,55] variant with C14GA38G mutations
7PH1 1.18 Å, Trypsin in complex with BPTI mutant (2S)-2-amino-4-monofluorobutanoic acid
9PTI 1.22 Å, Basic pancreatic trypsin inhibitor (met 52 oxidized)
4Y0Y 1.25 Å, Trypsin in complex with with BPTI
3P95 1.3 Å, Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor variant…
3WNY 1.3 Å, A simplified BPTI variant with poly Lys amino acid tag (C3K) at the C-terminus

Browse structure collections

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