5YU7: Exportin-5

Crystal structure of exportin-5. Determined by X-ray diffraction at 3.3 Å resolution. Released 29 Aug 2018.

Method
X-ray diffraction
Resolution
3.3 Å
Organism
Homo sapiens
Chains
1
Atoms
8,937
Mol. weight
136.45 kDa
Released
29 Aug 2018

Explore 5YU7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5YU7 contains 72 α-helices and 8 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 72 helices, 8 β-strands

ElementResiduesLengthSheet
α-helix7-2014
α-helix27-4317
α-helix47-548
α-helix61-7616
α-helix84-9916
α-helix110-13122
α-helix135-14511
α-helix147-16216
α-helix163-1675
α-helix172-18413
α-helix186-20621
α-helix214-23522
α-helix240-2434
α-helix249-2579
α-helix264-27512
α-helix282-29110
α-helix293-30816
α-helix315-33622
β-strand33711
β-strand34011
α-helix349-36012
α-helix365-38016
α-helix384-3863
α-helix388-40518
α-helix418-4258
α-helix429-45123
α-helix455-47117
α-helix498-52023
α-helix523-5253
α-helix528-54013
α-helix546-55914
α-helix560-5645
α-helix567-5693
α-helix570-58112
α-helix592-5932
β-strand59412
α-helix595-61420
α-helix616-6194
α-helix620-6223
α-helix623-63513
α-helix642-65615
α-helix657-6593
α-helix662-68019
α-helix683-6886
α-helix692-6998
α-helix712-73423
α-helix741-7466
β-strand750-75343
β-strand759-76133
α-helix766-78621
α-helix789-7924
α-helix805-8062
α-helix807-8137
α-helix816-8194
β-strand82712
α-helix832-85726
α-helix859-8635
α-helix868-8758
α-helix885-8917
α-helix892-8965
α-helix897-9015
α-helix908-9125
α-helix913-93523
α-helix953-97725
β-strand97814
β-strand101114
α-helix1013-10197
α-helix1023-103412
α-helix1035-10373
α-helix1041-10477
α-helix1048-10525
α-helix1054-10574
α-helix1060-10667
α-helix1069-108214
α-helix1087-109913
α-helix1101-11044
α-helix1112-11154
α-helix1123-113412
α-helix1147-11504
α-helix1167-11715

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Exportin-5Aprotein1204Homo sapiensQ9HAV4 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>5YU7_1 Exportin-5 (chains A)
MAMDQVNALCEQLVKAVTVMMDPNSTQRYRLEALKFCEEFKEKCPICVPCGLRLAEKTQV
AIVRHFGLQILEHVVKFRWNGMSRLEKVYLKNSVMELIANGTLNILEEENHIKDALSRIV
VEMIKREWPQHWPDMLIELDTLSKQGETQTELVMFILLRLAEDVVTFQTLPPQRRRDIQQ
TLTQNMERIFSFLLNTLQENVNKYQQVKTDTSQESKAQANCRVGVAALNTLAGYIDWVSM
SHITAENCKLLEILCLLLNEQELQLGAAECLLIAVSRKGKLEDRKPLMVLFGDVAMHYIL
SAAQTADGGGLVEKHYVFLKRLCQVLCALGNQLCALLGADSDVETPSNFGKYLESFLAFT
THPSQFLRSSTQMTWGALFRHEILSRDPLLLAIIPKYLRASMTNLVKMGFPSKTDSPSCE
YSRFDFDSDEDFNAFFNSSRAQQGEVMRLACRLDPKTSFQMAGEWLKYQLSTFLDAGSVN
SCSAVGTGEGSLCSVFSPSFVQWEAMTLFLESVITQMFRTLNREEIPVNDGIELLQMVLN
FDTKDPLILSCVLTNVSALFPFVTYRPEFLPQVFSKLFSSVTFETVEESKAPRTRAVRNV
RRHACSSIIKMCRDYPQLVLPNFDMLYNHVKQLLSNELLLTQMEKCALMEALVLISNQFK
NYERQKVFLEELMAPVASIWLSQDMHRVLSDVDAFIAYVGTDQKSCDPGLEDPCGLNRAR
MSFCVYSILGVVKRTCWPTDLEEAKAGGFVVGYTSSGNPIFRNPCTEQILKLLDNLLALI
RTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILGLPQPLLELNDSPVFKTVLERMQRFF
STLYENCFHILGKAGPSMQQDFYTVEDLATQLLSSAFVNLNNIPDYRLRPMLRVFVKPLV
LFCPPEHYEALVSPILGPLFTYLHMRLSQKWQVINQRSLLCGEDEAADENPESQEMLEEQ
LVRMLTREVMDLITVCCVSKKGADHSSAPPADGDDEEMMATEVTPSAMAELTDLGKCLMK
HEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTLLADAVTWLFTSVLKGL
QMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSLDQFDCKLLNPSLQK
VADKRRKDQFKRLIAGCIGKPLGEQFRKEVHIKNLPSLFKKTKPMLETEVLDNDGGGLAT
IFEP

Primary citation

Structural Basis for Selective Binding of Export Cargoes by Exportin-5. Yamazawa, R., Jiko, C., Choi, S. et al. Structure (2018) 26:1393-1398.e2. DOI 10.1016/j.str.2018.06.014 · PubMed

Other PDB entries of the same protein (UniProt Q9HAV4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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