5Z3G: Nucleolar pre-60S ribosome

Cryo-EM structure of a nucleolar pre-60S ribosome (Rpf1-TAP). Determined by electron microscopy at 3.65 Å resolution. Released 11 Apr 2018.

Method
Electron microscopy
Resolution
3.65 Å
Organisms
Saccharomyces cerevisiae, Saccharomyces cerevisiae S288c
Chains
35
Atoms
85,899
Mol. weight
2136.09 kDa
Released
11 Apr 2018

Explore 5Z3G in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

5Z3G contains 247 α-helices and 271 β-strands across 32 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 5 helices, 15 β-strands

ElementResiduesLengthSheet
β-strand33-3751
α-helix43-5513
β-strand60-6121
α-helix74-807
β-strand85-8951
β-strand9212
β-strand9612
β-strand99-10241
β-strand109-11133
β-strand115-11844
β-strand136-14054
α-helix141-1455
α-helix147-15913
β-strand175-18284
β-strand185-194104
β-strand211-21444
β-strand218-22144
β-strand225-22953
β-strand232-23873
α-helix245-2528
Chain b: 3 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix199-20810
β-strand222-22544
α-helix239-26325
α-helix270-2712
Chain c: 6 helices, 9 β-strands
ElementResiduesLengthSheet
α-helix12-209
α-helix26-294
β-strand33-3425
β-strand3516
α-helix37-393
α-helix40-445
β-strand47-4825
β-strand55-5846
β-strand67-6936
β-strand70-7237
β-strand81-8887
β-strand94-9857
α-helix101-1033
β-strand104-10856
α-helix113-1219
Chain d: 8 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix92-11726
α-helix133-17139
α-helix182-1876
α-helix201-21111
α-helix222-2298
α-helix241-2477
α-helix262-2654
α-helix272-2776
Chain D: 11 helices, 9 β-strands
ElementResiduesLengthSheet
α-helix58-8427
β-strand100-10458
β-strand129-13358
β-strand140-14679
α-helix157-16610
β-strand173-17979
α-helix187-1904
β-strand194-19749
α-helix201-2099
β-strand213-215310
β-strand226-228310
α-helix232-2387
α-helix248-2547
α-helix262-2687
β-strand271-27229
α-helix273-2753
α-helix282-29817
α-helix307-3082
β-strand309-31138
α-helix314-3218
Chain E: 4 helices, 8 β-strands
ElementResiduesLengthSheet
β-strand89-96811
α-helix104-1118
β-strand113112
β-strand115112
β-strand119-124611
β-strand131-138811
α-helix142-15211
β-strand156-157213
β-strand160-161213
β-strand164-168511
α-helix183-1853
α-helix193-21321
Chain F: 7 helices, 22 β-strands
ElementResiduesLengthSheet
β-strand43115
β-strand45-601616
β-strand72-811016
β-strand84-941117
β-strand99-101317
α-helix112-1165
α-helix131-1355
α-helix1361
α-helix145-1539
β-strand157-163717
α-helix166-1683
β-strand178-182517
β-strand183115
α-helix189-19810
β-strand201-203317
β-strand214-215218
β-strand216-218316
β-strand220119
β-strand225120
β-strand270120
β-strand274119
β-strand280-281218
β-strand282-285416
β-strand311121
β-strand314121
β-strand320-325616
β-strand334-339616
β-strand354-359616
α-helix373-3808
Chain G: 14 helices, 13 β-strands
ElementResiduesLengthSheet
β-strand5-6225
β-strand9126
β-strand20-21225
α-helix29-302
α-helix32-4312
β-strand63127
β-strand76127
β-strand88127
α-helix115-13117
α-helix134-1385
β-strand150-152326
α-helix154-1585
α-helix162-17211
α-helix175-1806
β-strand186-187228
β-strand199-200228
β-strand206-209429
α-helix216-2216
β-strand226-229429
α-helix235-2384
β-strand248129
β-strand249-251326
α-helix252-26110
α-helix287-2904
α-helix321-3266
α-helix331-3344
α-helix353-3608

24 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
25S rRNAARNA3396Saccharomyces cerevisiae
5.8S rRNABRNA158Saccharomyces cerevisiae
ITS2 RNACRNA232Saccharomyces cerevisiae
Ribosome biogenesis protein RLP7Dprotein322Saccharomyces cerevisiae S288cP40693 (AlphaFold model)
Ribosome biogenesis protein 15Eprotein220Saccharomyces cerevisiae S288cP53927 (AlphaFold model)
60S ribosomal protein L3Fprotein387Saccharomyces cerevisiae S288cP14126 (AlphaFold model)
60S ribosomal protein L4-AGprotein362Saccharomyces cerevisiae S288cP10664 (AlphaFold model)
Proteasome-interacting protein CIC1Hprotein376Saccharomyces cerevisiae S288cP38779
60S ribosomal protein L6-AIprotein176Saccharomyces cerevisiae S288cQ02326
60S ribosomal protein L7-AJprotein244Saccharomyces cerevisiae S288cP05737
60S ribosomal protein L8-AKprotein256Saccharomyces cerevisiae S288cP17076
60S ribosomal protein L9-ALprotein191Saccharomyces cerevisiae S288cP05738

23 more molecules are not listed.

Sequence of entity 1 (A), FASTA
>5Z3G_1 25S rRNA (chains A)
GUUUGACCUCAAAUCAGGUAGGAGUACCCGCUGAACUUAAGCAUAUCAAUAAGCGGAGGA
AAAGAAACCAACCGGGAUUGCCUUAGUAACGGCGAGUGAAGCGGCAAAAGCUCAAAUUUG
AAAUCUGGUACCUUCGGUGCCCGAGUUGUAAUUUGGAGAGGGCAACUUUGGGGCCGUUCC
UUGUCUAUGUUCCUUGGAACAGGACGUCAUAGAGGGUGAGAAUCCCGUGUGGCGAGGAGU
GCGGUUCUUUGUAAAGUGCCUUCGAAGAGUCGAGUUGUUUGGGAAUGCAGCUCUAAGUGG
GUGGUAAAUUCCAUCUAAAGCUAAAUAUUGGCGAGAGACCGAUAGCGAACAAGUACAGUG
AUGGAAAGAUGAAAAGAACUUUGAAAAGAGAGUGAAAAAGUACGUGAAAUUGUUGAAAGG
GAAGGGCAUUUGAUCAGACAUGGUGUUUUGUGCCCUCUGCUCCUUGUGGGUAGGGGAAUC
UCGCAUUUCACUGGGCCAGCAUCAGUUUUGGUGGCAGGAUAAAUCCAUAGGAAUGUAGCU
UGCCUCGGUAAGUAUUAUAGCCUGUGGGAAUACUGCCAGCUGGGACUGAGGACUGCGACG
UAAGUCAAGGAUGCUGGCAUAAUGGUUAUAUGCCGCCCGUCUUGAAACACGGACCAAGGA
GUCUAACGUCUAUGCGAGUGUUUGGGUGUAAAACCCAUACGCGUAAUGAAAGUGAACGUA
GGUUGGGGCCUCGCAAGAGGUGCACAAUCGACCGAUCCUGAUGUCUUCGGAUGGAUUUGA
GUAAGAGCAUAGCUGUUGGGACCCGAAAGAUGGUGAACUAUGCCUGAAUAGGGUGAAGCC
AGAGGAAACUCUGGUGGAGGCUCGUAGCGGUUCUGACGUGCAAAUCGAUCGUCGAAUUUG
GGUAUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCUGCCGAAGUUUCCCU
CAGGAUAGCAGAAGCUCGUAUCAGUUUUAUGAGGUAAAGCGAAUGAUUAGAGGUUCCGGG
GUCGAAAUGACCUUGACCUAUUCUCAAACUUUAAAUAUGUAAGAAGUCCUUGUUACUUAA
UUGAACGUGGACAUUUGAAUGAAGAGCUUUUAGUGGGCCAUUUUUGGUAAGCAGAACUGG
CGAUGCGGGAUGAACCGAACGUAGAGUUAAGGUGCCGGAAUACACGCUCAUCAGACACCA
CAAAAGGUGUUAGUUCAUCUAGACAGCCGGACGGUGGCCAUGGAAGUCGGAAUCCGCUAA
GGAGUGUGUAACAACUCACCGGCCGAAUGAACUAGCCCUGAAAAUGGAUGGCGCUCAAGC
GUGUUACCUAUACUCUACCGUCAGGGUUGAUAUGAUGCCCUGACGAGUAGGCAGGCGUGG
AGGUCAGUGACGAAGCCUAGACCGUAAGGUCGGGUCGAACGGCCUCUAGUGCAGAUCUUG
GUGGUAGUAGCAAAUAUUCAAAUGAGAACUUUGAAGACUGAAGUGGGGAAAGGUUCCACG
UCAACAGCAGUUGGACGUGGGUUAGUCGAUCCUAAGAGAUGGGGAAGCUCCGUUUCAAAG
GCCUGAUUUUAUGCAGGCCACCAUCGAAAGGGAAUCCGGUUAAGAUUCCGGAACCUGGAU
AUGGAUUCUUCACGGUAACGUAACUGAAUGUGGAGACGUCGGCGCGAGCCCUGGGAGGAG
UUAUCUUUUCUUCUUAACAGCUUAUCACCCCGGAAUUGGUUUAUCCGGAGAUGGGGUCUU
AUGGCUGGAAGAGGCCAGCACCUUUGCUGGCUCCGGUGCGCUUGUGACGGCCCGUGAAAA
UCCACAGGAAGGAAUAGUUUUCAUGCCAGGUCGUACUGAUAACCGCAGCAGGUCUCCAAG
GUGAACAGCCUCUAGUUGAUAGAAUAAUGUAGAUAAGGGAAGUCGGCAAAAUAGAUCCGU
AACUUCGGGAUAAGGAUUGGCUCUAAGGGUCGGGUAGUGAGGGCCUUGGUCAGACGCAGC
GGGCGUGCUUGUGGACUGCUUGGUGGGGCUUGCUCUGCUAGGCGGACUACUUGCGUGCCU
UGUUGUAGACGGCCUUGGUAGGUCUCUUGUAGACCGUCGCUUGCUACAAUUAACGAUCAA
CUUAGAACUGGUACGGACAAGGGGAAUCUGACUGUCUAAUUAAAACAUAGCAUUGCGAUG
GUCAGAAAGUGAUGUUGACGCAAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAA
GAAAUUCAACCAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAA
AUGCCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUUAACGAGAUUCCCACUGUCCCU
AUCUACUAUCUAGCGAAACCACAGCCAAGGGAACGGGCUUGGCAGAAUCAGCGGGGAAAG
AAGACCCUGUUGAGCUUGACUCUAGUUUGACAUUGUGAAGAGACAUAGAGGGUGUAGAAU
AAGUGGGAGCUUCGGCGCCAGUGAAAUACCACUACCUUUAUAGUUUCUUUACUUAUUCAA
UGAAGCGGAGCUGGAAUUCAUUUUCCACGUUCUAGCAUUCAAGGUCCCAUUCGGGGCUGA
UCCGGGUUGAAGACAUUGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUAAACGA
UAACGCAGAUGUCCUAAGGGGGGCUCAUGGAGAACAGAAAUCUCCAGUAGAACAAAAGGG
UAAAAGCCCCCUUGAUUUUGAUUUUCAGUGUGAAUACAAACCAUGAAAGUGUGGCCUAUC
GAUCCUUUAGUCCCUCGGAAUUUGAGGCUAGAGGUGCCAGAAAAGUUACCACAGGGAUAA
CUGGCUUGUGGCAGUCAAGCGUUCAUAGCGACAUUGCUUUUUGAUUCUUCGAUGUCGGCU
CUUCCUAUCAUACCGAAGCAGAAUUCGGUAAGCGUUGGAUUGUUCACCCACUAAUAGGGA
ACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGAAUGUUA
CCGCAAUAGUAAUUGAACUUAGUACGAGAGGAACAGUUCAUUCGGAUAAUUGGUUUUUGC
GGCUGUCUGAUCAGGCAUUGCCGCGAAGCUACCAUCCGCUGGAUUAUGGCUGAACGCCUC
UAAGUCAGAAUCCAUGCUAGAACGCGGUGAUUUCUUUGCUCCACACAAUAUAGAUGGAUA
CGAAUAAGGCGUCCUUGUGGCGUCGCUGAACCAUAGCAGGCUAGCAACGGUGCACUUGGC
GGAAAGGCCUUGGGUGCUUGCUGGCGAAUUGCAAUGUCAUUUUGCGUGGGGAUAAAUCAU
UUGUAUACGACUUAGAUGUACAACGGGGUAUUGUAAGCAGUAGAGUAGCCUUGUUGUUAC
GAUCUGCUGAGAUUAAGCCUUUGUUGUCUGAUUUGU
Sequence of entity 2 (B), FASTA
>5Z3G_2 5.8S rRNA (chains B)
AAACUUUCAACAACGGAUCUCUUGGUUCUCGCAUCGAUGAAGAACGCAGCGAAAUGCGAU
ACGUAAUGUGAAUUGCAGAAUUCCGUGAAUCAUCGAAUCUUUGAACGCACAUUGCGCCCC
UUGGUAUUCCAGGGGGCAUGCCUGUUUGAGCGUCAUUU
Sequence of entity 3 (C), FASTA
>5Z3G_3 ITS2 RNA (chains C)
CCUUCUCAAACAUUCUGUUUGGUAGUGAGUGAUACUCUUUGGAGUUAACUUGAAAUUGCU
GGCCUUUUCAUUGGAUGUUUUUUUUCCAAAGAGAGGUUUCUCUGCGUGCUUGAGGUAUAA
UGCAAGUACGGUCGUUUUAGGUUUUACCAACUGCGGCUAAUCUUUUUUUAUACUGAGCGU
AUUGGAACGUUAUCGAUAAGAAGAGAGCGUCUAGGCGAACAAUGUUCUUAAA
Sequence of entity 4 (D), FASTA
>5Z3G_4 Ribosome biogenesis protein RLP7 (chains D)
MSSTQDSKAQTLNSNPEILLRKRRNADRTRIERQELAKKKREEQIKKKRSNKNKFVRAES
IVAKTLATSREKERIKRVSILEDKKAKNETQHIASGKDFILKITEKANGAEENSVDLEET
EEEEDDGLIREKTTYDGKPALLFIVRVRGPLAVNIPNKAFKILSLLRLVETNTGVFVKLT
KNVYPLLKVIAPYVVIGKPSLSSIRSLIQKRGRIIYKGENEAEPHEIVLNDNNIVEEQLG
DHGIICVEDIIHEIATMGESFSVCNFFLQPFKLNREVSGFGSLNRLRKIKQREAESRTRQ
FSNAATAPVIEVDIDSLLAKLN
Sequence of entity 5 (E), FASTA
>5Z3G_5 Ribosome biogenesis protein 15 (chains E)
MVKSTSKTSTKETVTKQPTEEKPIQEKEELALETSSSSSDEEDEKDEDEIEGLAASDDEQ
SGTHKIKRLNPKKQANEKKSKDKKTLEEYSGIIYVSRLPHGFHEKELSKYFAQFGDLKEV
RLARNKKTGNSRHYGFLEFVNKEDAMIAQESMNNYLLMGHLLQVRVLPKGAKIEKLYKYK
KRVLVEKGITKPVKQLKDNMKQKHEERIKKLAKSGIEFKW
Sequence of entity 6 (F), FASTA
>5Z3G_6 60S ribosomal protein L3 (chains F)
MSHRKYEAPRHGHLGFLPRKRAASIRARVKAFPKDDRSKPVALTSFLGYKAGMTTIVRDL
DRPGSKFHKREVVEAVTVVDTPPVVVVGVVGYVETPRGLRSLTTVWAEHLSDEVKRRFYK
NWYKSKKKAFTKYSAKYAQDGAGIERELARIKKYASVVRVLVHTQIRKTPLAQKKAHLAE
IQLNGGSISEKVDWAREHFEKTVAVDSVFEQNEMIDAIAVTKGHGFEGVTHRWGTKKLPR
KTHRGLRKVACIGAWHPAHVMWSVARAGQRGYHSRTSINHKIYRVGKGDDEANGATSFDR
TKKTITPMGGFVHYGEIKNDFIMVKGCIPGNRKRIVTLRKSLYTNTSRKALEEVSLKWID
TASKFGKGRFQTPAEKHAFMGTLKKDL
Sequence of entity 7 (G), FASTA
>5Z3G_7 60S ribosomal protein L4-A (chains G)
MSRPQVTVHSLTGEATANALPLPAVFSAPIRPDIVHTVFTSVNKNKRQAYAVSEKAGHQT
SAESWGTGRAVARIPRVGGGGTGRSGQGAFGNMCRGGRMFAPTKTWRKWNVKVNHNEKRY
ATASAIAATAVASLVLARGHRVEKIPEIPLVVSTDLESIQKTKEAVAALKAVGAHSDLLK
VLKSKKLRAGKGKYRNRRWTQRRGPLVVYAEDNGIVKALRNVPGVETANVASLNLLQLAP
GAHLGRFVIWTEAAFTKLDQVWGSETVASSKVGYTLPSHIISTSDVTRIINSSEIQSAIR
PAGQATQKRTHVLKKNPLKNKQVLLRLNPYAKVFAAEKLGSKKAEKTGTKPAAVFTETLK
HD
Sequence of entity 8 (H), FASTA
>5Z3G_8 Proteasome-interacting protein CIC1 (chains H)
MAKKSNSKKSTPVSTPSKEKKKVIEKKSSTAIPRERVIKAVNELIKFTSKPQDENNEEGN
NGKKNLLEDDEEELKKDLQLIVVNNKSFTGTSKSFKLKLLNVKHSFYKPWKEASATAVKD
FKVLLILKDSDIKKVSEDDLFDQLDSEGIKVDEIICGKDLKTVYKAYEARNAFISQFSLI
LADDSIVTSLPKLMGGKAYNKVETTPISIRTHANKEFSLTTLTNNIKKVYMNQLPVKLPR
GTTLNVHLGNLEWLRPEEFVDNVELISEQLIKAYQIRSIFIKTNRSPVLPLYYNQDVLDE
LEAKKDKIEETHEDDMVTIDGVQVHLSTFNKGLMEIANPSELGSIFSKQINNAKKRSSSE
LEKESSESEAVKKAKS
Sequence of entity 9 (I), FASTA
>5Z3G_9 60S ribosomal protein L6-A (chains I)
MSAQKAPKWYPSEDVAALKKTRKAARPQKLRASLVPGTVLILLAGRFRGKRVVYLKHLED
NTLLISGPFKVNGVPLRRVNARYVIATSTKVSVEGVNVEKFNVEYFAKEKLTKKEKKEAN
LFPEQQNKEIKAERVEDQKVVDKALIAEIKKTPLLKQYLSASFSLKNGDKPHMLKF
Sequence of entity 10 (J), FASTA
>5Z3G_10 60S ribosomal protein L7-A (chains J)
MAAEKILTPESQLKKSKAQQKTAEQVAAERAARKAANKEKRAIILERNAAYQKEYETAER
NIIQAKRDAKAAGSYYVEAQHKLVFVVRIKGINKIPPKPRKVLQLLRLTRINSGTFVKVT
KATLELLKLIEPYVAYGYPSYSTIRQLVYKRGFGKINKQRVPLSDNAIIEANLGKYGILS
IDDLIHEIITVGPHFKQANNFLWPFKLSNPSGGWGVPRKFKHFIQGGSFGNREEFINKLV
KSMN
Sequence of entity 11 (K), FASTA
>5Z3G_11 60S ribosomal protein L8-A (chains K)
MAPGKKVAPAPFGAKSTKSNKTRNPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRVQR
QKKILSIRLKVPPTIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAVAEGK
SKQDASPKPYAVKYGLNHVVALIENKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIV
KGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFADKYDEVKKHWGGGILGN
KAQAKMDKRAKNSDSA
Sequence of entity 12 (L), FASTA
>5Z3G_12 60S ribosomal protein L9-A (chains L)
MKYIQTEQQIEVPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVTFTKVNNQLIKVAVHNG
GRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPINVNIVEKDGAKFIEVRNFLGD
KKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAADLQQICRVRNKDIRKFLDGIY
VSHKGFITEDL

Primary citation

Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half-assembled intermediate. Zhou, D., Zhu, X., Zheng, S. et al. Protein Cell (2019) 10:120-130. DOI 10.1007/s13238-018-0526-7 · PubMed

Other PDB entries of the same protein (UniProt P40693 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

About this viewer

MolViewer shows 5Z3G directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.