6ATH: Cdk2/cyclin A/p27-KID-deltaC

Cdk2/cyclin A/p27-KID-deltaC. Determined by X-ray diffraction at 1.82 Å resolution. Released 12 Sept 2018.

Method
X-ray diffraction
Resolution
1.82 Å
Organism
Homo sapiens
Chains
3
Atoms
5,178
Mol. weight
72.55 kDa
Released
12 Sept 2018

Explore 6ATH in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6ATH contains 41 α-helices and 13 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 19 helices, 10 β-strands

ElementResiduesLengthSheet
β-strand19-2351
β-strand29-3681
α-helix46-5510
β-strand6312
α-helix64-652
β-strand66-7161
β-strand75-8171
β-strand85-8622
α-helix87-937
α-helix98-1003
α-helix101-12020
β-strand123-12423
α-helix130-1323
β-strand133-13532
β-strand141-14332
β-strand150-15123
α-helix156-1583
α-helix166-1683
α-helix171-1744
α-helix183-19816
α-helix208-21912
α-helix230-2323
α-helix243-2453
α-helix248-2514
α-helix257-26610
α-helix275-2762
α-helix277-2804
α-helix284-2863
α-helix292-2943
Chain B: 20 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix179-19214
α-helix194-1963
α-helix199-2024
α-helix208-22417
α-helix229-24517
α-helix250-26819
α-helix272-2743
α-helix275-2817
α-helix288-30114
α-helix311-3199
α-helix327-34216
α-helix344-3474
α-helix352-36817
α-helix374-3807
α-helix384-40017
α-helix401-4033
α-helix408-4125
α-helix416-4183
α-helix421-4233
α-helix425-4273
Chain C: 2 helices, 3 β-strands
ElementResiduesLengthSheet
α-helix38-4710
α-helix55-606
β-strand62-6324
β-strand68-6924
β-strand74-7851

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cyclin-dependent kinase 2Aprotein300Homo sapiensP24941 (AlphaFold model)
Cyclin-A2Bprotein263Homo sapiensP20248 (AlphaFold model)
Cyclin-dependent kinase inhibitor 1BCprotein68Homo sapiensP46527 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>6ATH_1 Cyclin-dependent kinase 2 (chains A)
GSMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL
NHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC
HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK
YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP
SFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Sequence of entity 2 (B), FASTA
>6ATH_2 Cyclin-A2 (chains B)
GSMNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQN
ETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKK
QVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLK
YLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSI
REKYKNSKYHGVSLLNPPETLNL
Sequence of entity 3 (C), FASTA
>6ATH_3 Cyclin-dependent kinase inhibitor 1B (chains C)
GSHMEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQ
EVEKGSLP

Primary citation

Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation. Tsytlonok, M., Sanabria, H., Wang, Y. et al. Nat Commun (2019) 10:1676-1676. DOI 10.1038/s41467-019-09446-w · PubMed

Other PDB entries of the same protein (UniProt P24941 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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