The Structure of the Actin-Smooth Muscle Myosin Motor Domain Complex in the Rigor State. Determined by electron microscopy at 6.0 Å resolution. Released 19 Sept 2018.
Explore 6BIH in 3D Show helices and sheets RCSB PDB PDBe
6BIH contains 57 α-helices and 47 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 8-11 | 4 | 8 |
| β-strand | 17-21 | 5 | 8 |
| β-strand | 29-31 | 3 | 8 |
| β-strand | 35-38 | 4 | 9 |
| β-strand | 53-54 | 2 | 9 |
| α-helix | 56-60 | 5 | |
| β-strand | 65-68 | 4 | 9 |
| β-strand | 71 | 1 | 10 |
| β-strand | 76 | 1 | 10 |
| α-helix | 79-87 | 9 | |
| α-helix | 88-93 | 6 | |
| β-strand | 103-107 | 5 | 8 |
| α-helix | 113-123 | 11 | |
| β-strand | 131-136 | 6 | 8 |
| α-helix | 137-144 | 8 | |
| β-strand | 150 | 1 | 11 |
| β-strand | 152-154 | 3 | 12 |
| β-strand | 160-162 | 3 | 12 |
| β-strand | 165 | 1 | 11 |
| β-strand | 169 | 1 | 11 |
| β-strand | 176-178 | 3 | 12 |
| α-helix | 182-196 | 15 | |
| α-helix | 203-216 | 14 | |
| α-helix | 223-229 | 7 | |
| β-strand | 238-242 | 5 | 13 |
| β-strand | 246-250 | 5 | 13 |
| α-helix | 252-255 | 4 | |
| α-helix | 257-262 | 6 | |
| α-helix | 264-266 | 3 | |
| α-helix | 271-273 | 3 | |
| α-helix | 274-282 | 9 | |
| α-helix | 287-295 | 9 | |
| β-strand | 297-300 | 4 | 12 |
| α-helix | 302-304 | 3 | |
| α-helix | 309-319 | 11 | |
| β-strand | 329-330 | 2 | 12 |
| α-helix | 338-348 | 11 | |
| α-helix | 350-354 | 5 | |
| β-strand | 357-358 | 2 | 8 |
| α-helix | 359-365 | 7 | |
| α-helix | 366-368 | 3 | |
| α-helix | 369-373 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 8-11 | 4 | |
| β-strand | 34 | 1 | 1 |
| β-strand | 47-53 | 7 | 1 |
| β-strand | 56-61 | 6 | 1 |
| β-strand | 66-71 | 6 | 1 |
| α-helix | 72-74 | 3 | |
| α-helix | 77-80 | 4 | |
| α-helix | 81-83 | 3 | |
| β-strand | 88 | 1 | 2 |
| α-helix | 89-91 | 3 | |
| α-helix | 97-109 | 13 | |
| β-strand | 114-117 | 4 | 2 |
| β-strand | 120-124 | 5 | 2 |
| α-helix | 135-141 | 7 | |
| α-helix | 146-148 | 3 | |
| α-helix | 153-165 | 13 | |
| β-strand | 171-177 | 7 | 2 |
| α-helix | 183-197 | 15 | |
| α-helix | 221-233 | 13 | |
| β-strand | 236-237 | 2 | 3 |
| β-strand | 238 | 1 | 4 |
| β-strand | 245-246 | 2 | 3 |
| β-strand | 249-257 | 9 | 2 |
| β-strand | 261-270 | 10 | 2 |
| α-helix | 274-277 | 4 | |
| β-strand | 285 | 1 | 4 |
| α-helix | 289-296 | 8 | |
| α-helix | 299-304 | 6 | |
| α-helix | 310-312 | 3 | |
| α-helix | 328-342 | 15 | |
| α-helix | 346-363 | 18 | |
| α-helix | 382-391 | 10 | |
| α-helix | 395-403 | 9 | |
| β-strand | 406-408 | 3 | 5 |
| β-strand | 413-415 | 3 | 5 |
| α-helix | 420-450 | 31 | |
| β-strand | 459-467 | 9 | 2 |
| β-strand | 475 | 1 | 6 |
| α-helix | 477-507 | 31 | |
| α-helix | 517-520 | 4 | |
| α-helix | 522-529 | 8 | |
| α-helix | 537-544 | 8 | |
| α-helix | 552-562 | 11 | |
| α-helix | 563-565 | 3 | |
| β-strand | 569-570 | 2 | 6 |
| α-helix | 571-573 | 3 | |
| α-helix | 576-578 | 3 | |
| β-strand | 581-585 | 5 | 6 |
| β-strand | 588-592 | 5 | 6 |
| α-helix | 597-599 | 3 | |
| α-helix | 607-614 | 8 | |
| α-helix | 619-624 | 6 | |
| α-helix | 659-675 | 17 | |
| β-strand | 678-685 | 8 | 2 |
| α-helix | 698-708 | 11 | |
| α-helix | 710-718 | 9 | |
| β-strand | 722 | 1 | 7 |
| β-strand | 725-726 | 2 | 7 |
| α-helix | 727-734 | 8 | |
| α-helix | 749-760 | 12 | |
| β-strand | 767-769 | 3 | 7 |
| β-strand | 773-776 | 4 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Myosin-11 | H | protein | 798 | Gallus gallus | P10587 (AlphaFold model) |
| Actin, alpha skeletal muscle | C | protein | 377 | Oryctolagus cuniculus | P68135 (AlphaFold model) |
>6BIH_1 Myosin-11 (chains H) MSQKPLSDDEKFLFVDKNFVNNPLAQADWSAKKLVWVPSEKHGFEAASIKEEKGDEVTVE LQENGKKVTLSKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLF CVVINPYKQLPIYSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESG AGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFSYGELEKQLLQANPILEAFGNAKTV KNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGASEQ MRNDLLLEGFNNYTFLSNGHVPIPAQQDDEMFQETLEAMTIMGFTEEEQTSILRVVSSVL QLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTK EQADFAIEALAKAKFERLFRWILTRVNKALDKTKRQGASFLGILDIAGFEIFEINSFEQL CINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLAL LDEECWFPKATDTSFVEKLIQEQGNHAKFQKSKQLKDKTEFCILHYAGKVTYNASAWLTK NMDPLNDNVTSLLNQSSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVG QLYKEQLTKLMTTLRNTNPNFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQG FPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGV LAHLEEERDLDYKDDDDK
>6BIH_2 Actin, alpha skeletal muscle (chains C) MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV MSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIT KQEYDEAGPSIVHRKCF
The structure of the actin-smooth muscle myosin motor domain complex in the rigor state. Banerjee, C., Hu, Z., Huang, Z. et al. J Struct Biol (2017) 200:325-333. DOI 10.1016/j.jsb.2017.10.003 · PubMed
Other PDB entries of the same protein (UniProt P10587 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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