SdcA in complex with the E2, UbcH5C. Determined by X-ray diffraction at 3.01 Å resolution. Released 1 Aug 2018.
Explore 6CP0 in 3D Show helices and sheets RCSB PDB PDBe
6CP0 contains 32 α-helices and 25 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 19-21 | 3 | 1 |
| β-strand | 27-29 | 3 | 1 |
| β-strand | 30-35 | 6 | 2 |
| β-strand | 39 | 1 | 3 |
| α-helix | 44-46 | 3 | |
| α-helix | 49-56 | 8 | |
| α-helix | 67-91 | 25 | |
| α-helix | 97-123 | 27 | |
| α-helix | 129-135 | 7 | |
| α-helix | 139-142 | 4 | |
| α-helix | 143-151 | 9 | |
| β-strand | 155-159 | 5 | 3 |
| β-strand | 174-177 | 4 | 3 |
| α-helix | 181 | 1 | |
| β-strand | 182 | 1 | 4 |
| α-helix | 183 | 1 | |
| β-strand | 191 | 1 | 4 |
| α-helix | 197-205 | 9 | |
| β-strand | 209 | 1 | 5 |
| β-strand | 212 | 1 | 5 |
| β-strand | 214-215 | 2 | 6 |
| α-helix | 221-230 | 10 | |
| α-helix | 244-262 | 19 | |
| β-strand | 270 | 1 | 7 |
| α-helix | 275 | 1 | |
| β-strand | 276 | 1 | 7 |
| α-helix | 277 | 1 | |
| α-helix | 279-280 | 2 | |
| α-helix | 281-285 | 5 | |
| α-helix | 295-306 | 12 | |
| β-strand | 333-334 | 2 | 6 |
| α-helix | 337-360 | 24 | |
| α-helix | 368-372 | 5 | |
| α-helix | 375-391 | 17 | |
| α-helix | 395-406 | 12 | |
| α-helix | 418-435 | 18 | |
| β-strand | 443-447 | 5 | 3 |
| β-strand | 456-458 | 3 | 2 |
| β-strand | 461-465 | 5 | 2 |
| α-helix | 466-473 | 8 | |
| α-helix | 481-485 | 5 | |
| α-helix | 486-491 | 6 | |
| β-strand | 497 | 1 | 2 |
| α-helix | 503-506 | 4 | |
| α-helix | 509-520 | 12 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 0-15 | 16 | |
| β-strand | 21-25 | 5 | 8 |
| β-strand | 32-38 | 7 | 8 |
| β-strand | 49-55 | 7 | 8 |
| β-strand | 66-69 | 4 | 8 |
| β-strand | 78 | 1 | 9 |
| β-strand | 83 | 1 | 8 |
| β-strand | 84 | 1 | 9 |
| α-helix | 87-89 | 3 | |
| α-helix | 99-111 | 13 | |
| α-helix | 121-129 | 9 | |
| α-helix | 131-145 | 15 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| SdcA | A | protein | 538 | Legionella pneumophila | Q6RCR3 (AlphaFold model) |
| Ubiquitin-conjugating enzyme E2 D3 | B | protein | 149 | Homo sapiens | P61077 (AlphaFold model) |
>6CP0_1 SdcA (chains A) MMNMVDKIKFKEPERCEYLHIAKDNKVHILLPIVGGDEIGLDNTAETTGELLTFFYGKTH GGTKYSAEHHLNEYKKNLEDDIKAIGVQRKISPNAYEDLLKEKKERLEQIEKYIDLIKVL KEKFDEQREIDKLRTEGIPQLPSGVKEVIKSSENAFALRLSPDRPDSFTRFDDPLFSLKR NRSQYEAGGYQRATDGLGARLRSELLPPDKDTPIVFNKKSLKDKIVDSVLVQLDKDFNTK DGDRGQKFEDIKKLVLEEYKKIDSELQVDEDTYHQPLNLDYLENIACTLDDNSTAKDWVY GIIGATTEADYWPKKESESGTEKVSVFYEKQKEIKFESDTNTMSIKVQYLLAEINFYCKT NKLSDANFGEFFDKEPHATEVAKRVKEGLVQGAEIEPIIYNYINSHHAELGLTSELSSKQ QEEITEKFTQRYHIIENSPHFDEFFVADPDKKGNIFSHQGRMSCHFLDFFARQTKGKYPL GDLAGHQEALQAGTSNRLHHKNEVVAQGYEKFDQFKKEVVKLLAESKPKELLDYLVAT
>6CP0_2 Ubiquitin-conjugating enzyme E2 D3 (chains B) LAMALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPT DYPFKPPKVAFTTRIYHPNINSNGSISLDILRSQWSPALTISKVLLSICSLLCDPNPDDP LVPEIARIYKTDRDKYNRISREWTQKYAM
Insights into the ubiquitin transfer cascade catalyzed by theLegionellaeffector SidC. Wasilko, D.J., Huang, Q., Mao, Y. Elife (2018) 7. DOI 10.7554/eLife.36154 · PubMed
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