Crystal structure of the heterocomplex between human keratin 1 coil 1B containing S233L mutation and wild-type human keratin 10 coil 1B. Determined by X-ray diffraction at 2.39 Å resolution. Released 15 May 2019.
Explore 6E2J in 3D Show helices and sheets RCSB PDB PDBe
6E2J contains 2 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 228-330 | 103 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 194-295 | 102 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Keratin, type II cytoskeletal 1 | A | protein | 107 | Homo sapiens | P04264 (AlphaFold model) |
| Keratin, type I cytoskeletal 10 | B | protein | 104 | Homo sapiens | P13645 (AlphaFold model) |
>6E2J_1 Keratin, type II cytoskeletal 1 (chains A) MNLEPYFELFINNLRRRVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEF VTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQAELSQMQTQIS
>6E2J_2 Keratin, type I cytoskeletal 10 (chains B) GSDYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLKYENEVALRQSVEADI NGLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDLRN
Human keratin 1/10-1B tetramer structures reveal a knob-pocket mechanism in intermediate filament assembly. Eldirany, S.A., Ho, M., Hinbest, A.J. et al. EMBO J (2019) 38. DOI 10.15252/embj.2018100741 · PubMed
Other PDB entries of the same protein (UniProt P04264 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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