6E67: Beta2 adrenergic receptor fused to a Gs peptide

Structure of beta2 adrenergic receptor fused to a Gs peptide. Determined by X-ray diffraction at 3.7 Å resolution. Released 5 Jun 2019.

Method
X-ray diffraction
Resolution
3.7 Å
Organisms
Homo sapiens, Enterobacteria phage RB59
Chains
2
Atoms
7,207
Mol. weight
121.06 kDa
Ligands
P0G
Released
5 Jun 2019

Explore 6E67 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6E67 contains 56 α-helices and 8 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 27 helices, 3 β-strands

ElementResiduesLengthSheet
α-helix30-5930
α-helix67-8115
α-helix82-865
α-helix87-9610
α-helix103-13634
α-helix138-1447
α-helix147-17024
α-helix179-1868
α-helix197-2048
α-helix205-2095
α-helix210-22516
α-helix226-2283
α-helix229-100710
α-helix1008-10125
β-strand1014-101961
β-strand1025-102841
β-strand1031-103441
α-helix1039-105012
α-helix1060-108021
α-helix1085-10906
α-helix1093-111119
α-helix1115-11228
α-helix1126-11349
α-helix1137-11415
α-helix1143-115513
α-helix2381-239313
α-helix268-29831
α-helix305-32117
α-helix322-3243
α-helix330-33910
Chain B: 29 helices, 5 β-strands
ElementResiduesLengthSheet
α-helix20-234
α-helix30-5930
α-helix62-643
α-helix67-8115
α-helix82-865
α-helix87-9610
α-helix102-13635
α-helix138-1447
α-helix147-16317
α-helix167-1704
β-strand17512
α-helix179-1868
β-strand19512
α-helix197-2048
α-helix205-2095
α-helix210-22516
α-helix229-101013
β-strand1014-101963
β-strand1025-102843
β-strand1031-103223
α-helix1039-105012
α-helix1060-108021
α-helix1084-10907
α-helix1093-110311
α-helix1108-11125
α-helix1115-11228
α-helix1126-113510
α-helix1137-11415
α-helix1143-115513
α-helix2381-239313
α-helix268-29831
α-helix305-32117
α-helix322-3243
α-helix330-33910

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha…A, Bprotein531Homo sapiens, Enterobacteria phage RB59A0A097J809, P07550 (AlphaFold model), P63092 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>6E67_1 Beta-2 adrenergic receptor,Endolysin,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Beta-2 adrenergic receptor chimera (chains A, B)
MKTIIALSYIFCLVFADYKDDDDAMGQPGNGSAFLLAPNRSHAPDHDVTQQRDEVWVVGM
GIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILT
KTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILM
VWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMV
FVYSRVFQECKRQLQKNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSE
LDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQ
MGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYDIIQ
RMHLRQYELCGTGEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWI
GYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSG

Ligands and cofactors

IDNameFormulaCopies
P0G8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydro…C21 H26 N2 O42

Primary citation

Structural Insights into the Process of GPCR-G Protein Complex Formation. Liu, X., Xu, X., Hilger, D. et al. Cell (2019) 177:1243-1251.e12. DOI 10.1016/j.cell.2019.04.021 · PubMed

Other PDB entries of the same protein (UniProt A0A097J809), best resolution first:

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