6E7C: Tubulin beta-2B chain

14-pf 3-start GMPCPP-human alpha1B/beta2B microtubules. Determined by electron microscopy at 3.65 Å resolution. Released 10 Oct 2018.

Method
Electron microscopy
Resolution
3.65 Å
Organism
Homo sapiens
Chains
2
Atoms
6,780
Mol. weight
97.68 kDa
Ligands
MG, G2P, GTP
Released
10 Oct 2018

Explore 6E7C in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6E7C contains 41 α-helices and 38 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 19 helices, 15 β-strands

ElementResiduesLengthSheet
β-strand2-989
α-helix10-2718
α-helix48-514
β-strand55-56210
β-strand60-61210
β-strand65-6849
α-helix73-808
β-strand92-9329
α-helix103-1042
α-helix105-1095
α-helix112-12817
β-strand131-140109
α-helix145-16016
β-strand165-17289
α-helix183-19715
β-strand200-20129
β-strand204-20529
α-helix206-21510
α-helix224-24320
α-helix252-2598
α-helix2681
β-strand269-273511
α-helix278-2814
α-helix288-2936
β-strand312112
β-strand315-321711
α-helix325-33713
β-strand343112
β-strand351-354411
α-helix362-3632
β-strand373-379711
α-helix385-39915
α-helix405-4117
α-helix416-43621
Chain B: 22 helices, 23 β-strands
ElementResiduesLengthSheet
β-strand3-971
α-helix11-2717
β-strand3012
β-strand3513
β-strand3612
α-helix47-493
β-strand51-5443
β-strand58-6143
β-strand63-6641
α-helix70-789
β-strand9011
α-helix97-993
α-helix103-1086
α-helix113-12513
β-strand130-13781
β-strand13814
α-helix143-1464
α-helix148-15811
β-strand16311
β-strand169-17024
α-helix181-19515
β-strand199-20025
β-strand202-20324
α-helix204-2096
α-helix210-2145
α-helix222-2254
α-helix227-24115
α-helix250-2556
β-strand265-26625
β-strand267-26936
α-helix277-2793
α-helix286-2949
α-helix3091
β-strand310-31566
β-strand31617
β-strand31818
α-helix323-33614
β-strand34116
β-strand35217
α-helix357-3582
β-strand36418
β-strand367-37156
α-helix374-38916
α-helix395-3995
α-helix405-42319

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Tubulin beta-2B chainBprotein426Homo sapiensQ9BVA1 (AlphaFold model)
Tubulin alpha-1B chainAprotein437Homo sapiensP68363 (AlphaFold model)
Sequence of entity 1 (B), FASTA
>6E7C_1 Tubulin beta-2B chain (chains B)
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQ
Sequence of entity 2 (A), FASTA
>6E7C_2 Tubulin alpha-1B chain (chains A)
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGV

Ligands and cofactors

IDNameFormulaCopies
MGMagnesium ionMg2
G2PPhosphomethylphosphonic acid guanylate esterC11 H18 N5 O13 P31
GTPGuanosine-5'-triphosphateC10 H16 N5 O14 P31

Primary citation

Human beta-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability. Ti, S.C., Alushin, G.M., Kapoor, T.M. Dev Cell (2018) 47:175. DOI 10.1016/j.devcel.2018.08.014 · PubMed

Other PDB entries of the same protein (UniProt Q9BVA1 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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